Stuart M. Allan
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View article: Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions
Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions Open
Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous system. Notably these include gastrointestinal dysfunction and altered composition of the co…
View article: Association of Angiotensin Inhibitors with Improved Outcome after Acute Intracerebral Hemorrhage: Secondary Analysis of the INTERACT3 Trial
Association of Angiotensin Inhibitors with Improved Outcome after Acute Intracerebral Hemorrhage: Secondary Analysis of the INTERACT3 Trial Open
Introduction: Drug screening with a zebrafish model of acute intracerebral hemorrhage (ICH) identified a neuroprotective effect of angiotensin converting enzyme inhibitor (ACE-I) drugs. We identified an association of early ACE-I treatment…
View article: Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies
Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies Open
The blood-brain barrier (BBB) protects the brain from pathogenic microorganisms. Neurologic complications from viral infections, including herpes simplex virus, varicella zoster virus, HIV, Japanese encephalitis virus, and SARS-CoV-2, are …
View article: Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage
Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage Open
Intracerebral haemorrhage (ICH) is a devastating stroke subtype lacking effective therapies. Understanding key pathological processes related to acute brain damage will help deliver better outcomes for ICH. Herein, we provide evidence that…
View article: Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease
Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease Open
Cerebral small vessel disease (cSVD) is a major cause of vascular dementia and stroke. Our understanding of cSVD pathophysiology is incomplete and our ability to treat patients is limited. Pathogenic variants in type IV collagen alpha 1 (C…
View article: Innovative Cellular Therapy for Stroke: Primed MSCs Mitigating Neuroinflammation and Promoting Neuroprotection
Innovative Cellular Therapy for Stroke: Primed MSCs Mitigating Neuroinflammation and Promoting Neuroprotection Open
View article: Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study
Assessing post-stroke cognition in pre-clinical models: lessons and recommendations from a multi-center study Open
Cognitive decline is a significant long-term consequence of stroke and has no available treatments. To aid in therapy development, we sought to achieve robust detection of cognitive performance after stroke in a multi-site design. Ischemic…
View article: Graphene Micro-transistor Arrays Reveal Perfusion-Dependent Electrophysiological and Haemodynamic Signatures of Cortical Spreading Depolarizations in Ischaemic Stroke
Graphene Micro-transistor Arrays Reveal Perfusion-Dependent Electrophysiological and Haemodynamic Signatures of Cortical Spreading Depolarizations in Ischaemic Stroke Open
Cortical spreading depolarizations (CSDs) are large-scale disruptions of neuronal homeostasis that contribute to secondary injury in ischaemic stroke. In healthy cortex, CSDs induce vasodilation to meet metabolic demand, whereas in ischaem…
View article: Cerebral small vessel disease due to <i>Col4a1</i> mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding
Cerebral small vessel disease due to <i>Col4a1</i> mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding Open
White matter abnormalities are a hallmark of cerebral small vessel disease (cSVD) and are closely linked to cognitive decline and dementia. However, despite their clinical importance, underlying mechanisms remain poorly understood. Collage…
View article: Comparison of the Novel Thrombolytic Constitutively Active ADAMTS13 With Clinical Thrombolytics in a Murine Stroke Model
Comparison of the Novel Thrombolytic Constitutively Active ADAMTS13 With Clinical Thrombolytics in a Murine Stroke Model Open
BACKGROUND: r-tPA (recombinant tissue-type plasminogen activator) and its variant, TNK (tenecteplase), are the currently approved thrombolytic drugs for the treatment of acute ischemic stroke, but they are ineffective in a proportion of pa…
View article: Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke
Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke Open
Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading to poor outcome. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinic…
View article: Combining In Vivo Two‐Photon and Laser Speckle Microscopy With the Ex Vivo Capillary‐Parenchymal Arteriole Preparation as a Novel Approach to Study Neurovascular Coupling
Combining In Vivo Two‐Photon and Laser Speckle Microscopy With the Ex Vivo Capillary‐Parenchymal Arteriole Preparation as a Novel Approach to Study Neurovascular Coupling Open
Objective Cerebral blood flow (CBF) decline is increasingly recognized as an area of importance for targeting neurodegenerative disorders, yet full understanding of the mechanisms that underlie CBF changes are lacking. Animal models are cr…
View article: Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue
Evidence of aberrant anti-epstein-barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue Open
Background Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their imp…
View article: Inhibition of neutrophil rolling and migration by caADAMTS13 in vitro and in mouse models of thrombosis and inflammation
Inhibition of neutrophil rolling and migration by caADAMTS13 in vitro and in mouse models of thrombosis and inflammation Open
View article: Cerebral ischaemic stroke results in altered mucosal IgA responses and host-commensal microbiota interactions
Cerebral ischaemic stroke results in altered mucosal IgA responses and host-commensal microbiota interactions Open
Stroke is a devastating neurological event with a high risk of mortality, but also results in long-term sequalae in survivors that extend beyond the central nervous system. Notably, these include gastrointestinal dysfunction and alteration…
View article: The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome Open
Hyperinflammatory disease is associated with an aberrant immune response resulting in cytokine storm. One such instance of hyperinflammatory disease is known as macrophage activation syndrome (MAS). The pathology of MAS can be characterise…
View article: Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival Open
Myeloid cells are highly prevalent in glioblastoma (GBM), existing in a spectrum of phenotypic and activation states. We now have limited knowledge of the tumor microenvironment (TME) determinants that influence the localization and the fu…
View article: Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue
Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue Open
BACKGROUND Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their imp…
View article: Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue
Evidence of aberrant anti-Epstein-Barr virus antibody response, though no viral reactivation, in people with post-stroke fatigue Open
BACKGROUND Fatigue is a common complication of stroke that has a significant impact on quality of life. The biological mechanisms that underly post-stroke fatigue are currently unclear, however, reactivation of latent viruses and their imp…
View article: Baseline perihematomal edema, C-reactive protein, and 30-day mortality are not associated in intracerebral hemorrhage
Baseline perihematomal edema, C-reactive protein, and 30-day mortality are not associated in intracerebral hemorrhage Open
Background The relationship between baseline perihematomal edema (PHE) and inflammation, and their impact on survival after intracerebral hemorrhage (ICH) are not well understood. Objective Assess the association between baseline PHE, base…
View article: The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome Open
Hyperinflammatory disease is associated with an aberrant immune response resulting in cytokine storm. One such instance of hyperinflammatory disease is known as macrophage activation syndrome (MAS). The pathology of MAS can be characterise…
View article: Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but regulates neurorepair processes after experimental ischemic stroke
Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but regulates neurorepair processes after experimental ischemic stroke Open
Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading to poor outcome. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinic…
View article: Stroke and Translational Research – Review of Experimental Models with a Focus on Awake Ischaemic Induction and Anaesthesia
Stroke and Translational Research – Review of Experimental Models with a Focus on Awake Ischaemic Induction and Anaesthesia Open
Animal models are an indispensable tool in the study of ischaemic stroke with hundreds of drugs emerging from the preclinical pipeline. However, all of these drugs have failed to translate into successful treatments in the clinic. This has…
View article: Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke
Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke Open
View article: A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases Open
View article: Intracerebral Administration of a Novel Self-Assembling Peptide Hydrogel Is Safe and Supports Cell Proliferation in Experimental Intracerebral Haemorrhage
Intracerebral Administration of a Novel Self-Assembling Peptide Hydrogel Is Safe and Supports Cell Proliferation in Experimental Intracerebral Haemorrhage Open
Intracerebral haemorrhage (ICH) is the deadliest form of stroke, but current treatment options are limited, meaning ICH survivors are often left with life-changing disabilities. The significant unmet clinical need and socioeconomic burden …
View article: OC 03.1 Detailed Assessment of the Microenvironment of Stroke Thrombi Using Imaging Mass Cytometry
OC 03.1 Detailed Assessment of the Microenvironment of Stroke Thrombi Using Imaging Mass Cytometry Open
View article: Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice
Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice Open
Mesenchymal stem cell (MSC) pre-conditioning with interleukin-1 alpha (IL-1ɑ) drives MSCs toward a potent anti-inflammatory phenotype. The aim of this study was to assess the therapeutic potential of intra-arterially administered IL-1ɑ pre…
View article: Uncoupling of Ca <sup>2+</sup> sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia
Uncoupling of Ca <sup>2+</sup> sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia Open
The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular dementia is increasingly viewed as a therapeutic target for disease-modifying therapy. Progress is limited, however, due to uncertainty surroundin…
View article: Intracerebral administration of a novel self-assembling peptide hydrogel is safe and supports cell proliferation in experimental intracerebral haemorrhage
Intracerebral administration of a novel self-assembling peptide hydrogel is safe and supports cell proliferation in experimental intracerebral haemorrhage Open
Intracerebral haemorrhage (ICH) is the deadliest form of stroke but current treatment options are limited, meaning ICH survivors are often left with life-changing disabilities. The significant unmet clinical need and socioeconomic burden o…