Stuart M. Pitson
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View article: Sphingosine 1-phosphate signalling in cancer stem cells
Sphingosine 1-phosphate signalling in cancer stem cells Open
Cancer stem cells (CSCs) are considered the head of a hierarchical organisation of carcinogenesis, exhibiting heightened cell survival properties, an ability to endlessly self-renew and undergo attenuated differentiation to maintain the bu…
View article: Polymeric-lipid nanoparticles that leverage cationic helper lipids and the protein corona for lung-targeted delivery of a novel anti-cancer drug
Polymeric-lipid nanoparticles that leverage cationic helper lipids and the protein corona for lung-targeted delivery of a novel anti-cancer drug Open
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, highlighting the urgent need for more effective therapeutic strategies. Nanomedicine offers a promising avenue to improve treatment outcomes by enabling l…
View article: Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid Leukemia
Novel RNA Polymerase I and Cyclin Dependent Kinase combination therapy for the treatment of aggressive Acute Myeloid Leukemia Open
Despite advances in therapy, specific subtypes Acute Myeloid Leukaemia (AML) remains largely incurable. The first-in-class RNA Polymerase I (Pol I) inhibitor, CX-5461, has demonstrated promising activity in both haematological malignancies…
View article: A brain-penetrant CDK4/6 inhibitor - AU3-14 shows robust anti-tumor efficacy against glioblastoma
A brain-penetrant CDK4/6 inhibitor - AU3-14 shows robust anti-tumor efficacy against glioblastoma Open
The cyclin D-CDK4/6-INK4-Rb pathway is frequently dysregulated in glioblastoma (GBM), the most aggressive and poorly prognosed brain malignancy. Despite extensive research, advances in GBM treatment have seen limited progress, with current…
View article: Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice
Nedd4-2 ablation in kidney improves glycaemic control in diabetic mice Open
NEDD4-2, a ubiquitin ligase, regulates a number of ion channels and transporters by promoting their ubiquitination, internalisation and degradation, thereby affecting many signalling and physiological outcomes. Loss of this gene in mice re…
View article: A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors
A Characterization of the Immune Cells in Immunocompetent and Immunodeficient Mice with Orthotopic Brain Tumors Open
Background Glioblastoma is characterized by poor survival with few treatment advances for over 20 years. Active research is being conducted in immunotherapies; however, this may be hampered by the lack of detailed characterization of the i…
View article: Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer
Identification of Sphingosine Kinase 1 as a Novel Protein Regulated by High Molecular Weight Hyaluronan in Ovarian Cancer Open
The effects of hyaluronan (HA) in cancer are widely studied; however, the role of different molecular weight HA is poorly understood. Identifying novel proteins regulated by different molecular weight HA may highlight novel therapeutic tar…
View article: Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis
Accelerated Closure of Diabetic Wounds by Efficient Recruitment of Fibroblasts upon Inhibiting a 14-3-3/ROCK Regulatory Axis Open
Chronic non-healing wounds negatively impact quality of life and are a significant financial drain on health systems. The risk of infection that exacerbates comorbidities in patients necessitates regular application of wound care. Understa…
View article: Endogenous bystander killing mechanisms enhance the activity of novel FAP‐specific CAR‐T cells against glioblastoma
Endogenous bystander killing mechanisms enhance the activity of novel FAP‐specific CAR‐T cells against glioblastoma Open
Objectives CAR‐T cells are being investigated as a novel immunotherapy for glioblastoma, but clinical success has been limited. We recently described fibroblast activation protein (FAP) as an ideal target antigen for glioblastoma immunothe…
View article: An orthotopic syngeneic mouse model of bortezomib‐resistant multiple myeloma
An orthotopic syngeneic mouse model of bortezomib‐resistant multiple myeloma Open
Summary While bortezomib has significant benefits in multiple myeloma (MM) therapy, the disease remains incurable due to the invariable development of bortezomib resistance. This emphasises the need for advanced models for preclinical eval…
View article: Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs
Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs Open
Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay among transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs (FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2) bind regulatory …
View article: Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells
Cell Type-Specific Regulation by a Heptad of Transcription Factors in Human Hematopoietic Stem and Progenitor Cells Open
Summary Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - bind regu…
View article: Supplementary Methods, Supplementary Figures 1 through 6, and Supplementary Table 1 from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1
Supplementary Methods, Supplementary Figures 1 through 6, and Supplementary Table 1 from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1 Open
Supplementary Methods. Supplementary Figure S1. Validation of the physiological interaction between CIB2 and SK1 using proximity ligation assays with different antibody combinations. Supplementary Figure S2. N-myristoylation of CIB2 does n…
View article: Data from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1
Data from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1 Open
Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogenic signaling by SK1 relies on its localization to the plasma membrane, which is mediated by the calcium and in…
View article: Data from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1
Data from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1 Open
Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogenic signaling by SK1 relies on its localization to the plasma membrane, which is mediated by the calcium and in…
View article: Supplementary Methods, Supplementary Figures 1 through 6, and Supplementary Table 1 from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1
Supplementary Methods, Supplementary Figures 1 through 6, and Supplementary Table 1 from CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1 Open
Supplementary Methods. Supplementary Figure S1. Validation of the physiological interaction between CIB2 and SK1 using proximity ligation assays with different antibody combinations. Supplementary Figure S2. N-myristoylation of CIB2 does n…
View article: Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
Sphingosine kinase 2 (SK2) may have utility as a prognostic marker in inflammatory diseases such as cancer in which it has been rationalized as a candidate therapeutic target. Here, we show that SK2 has an oncogenic role in acute lymphobla…
View article: Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Data from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
Sphingosine kinase 2 (SK2) may have utility as a prognostic marker in inflammatory diseases such as cancer in which it has been rationalized as a candidate therapeutic target. Here, we show that SK2 has an oncogenic role in acute lymphobla…
View article: Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
PDF file - 1070KB, Supplementary methods, Tables S1-S5 and Figures S1-S14 Table S1. Patient Information Table S2. Primers. Table S3. Regulation of c-Myc Target Genes by SK2 Inhibition Table S4. Gene Enrichment Analysis for All Nine Cell Li…
View article: Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression
Supplementary Methods, Figures 1 - 14, Tables 1 - 5 from Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing <i>MYC</i> Expression Open
PDF file - 1070KB, Supplementary methods, Tables S1-S5 and Figures S1-S14 Table S1. Patient Information Table S2. Primers. Table S3. Regulation of c-Myc Target Genes by SK2 Inhibition Table S4. Gene Enrichment Analysis for All Nine Cell Li…
View article: Dynamic interplay between sortilin and syndecan-1 drives a metabolic switch during prostate cancer progression
Dynamic interplay between sortilin and syndecan-1 drives a metabolic switch during prostate cancer progression Open
Prostate cancer (PCa) development and progression relies on the programming of glucose and lipid metabolism, and this involves alterations in androgen receptor expression and signalling. Defining the molecular mechanism that underpins this…
View article: Mitochondrial translocation of TFEB regulates complex I and inflammation
Mitochondrial translocation of TFEB regulates complex I and inflammation Open
TFEB is a master regulator of autophagy, lysosome biogenesis and mitochondrial metabolism that works, and immunity, primarily through transcription controlled by cytosol-to-nuclear translocation. Emerging data indicate additional regulator…
View article: GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma
GD2-targeting CAR-T cells enhanced by transgenic IL-15 expression are an effective and clinically feasible therapy for glioblastoma Open
Background Aggressive primary brain tumors such as glioblastoma are uniquely challenging to treat. The intracranial location poses barriers to therapy, and the potential for severe toxicity. Effective treatments for primary brain tumors ar…