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View article: Insights into the Global Practice of Paediatric Renal Scintigraphy Studies
Insights into the Global Practice of Paediatric Renal Scintigraphy Studies Open
Congenital abnormalities of the kidney and urinary tract are amongst the most common in children, often requiring nuclear medicine imaging for diagnosis and treatment planning. Efforts to harmonise paediatric renal scintigraphy have gained…
View article: Early-stage Hodgkin lymphoma in Cape Town, South Africa: prognostic risk factors at diagnosis and treatment outcomes
Early-stage Hodgkin lymphoma in Cape Town, South Africa: prognostic risk factors at diagnosis and treatment outcomes Open
Background Classic Hodgkin Lymphoma (cHL) is a highly curable cancer disproportionately affecting younger patients and those with human immunodeficiency virus (HIV) infection. In under-resourced regions with endemic HIV or tuberculosis, cH…
View article: Randomized controlled trial of an oral gastrin receptor antagonist for the treatment of postmenopausal osteoporosis
Randomized controlled trial of an oral gastrin receptor antagonist for the treatment of postmenopausal osteoporosis Open
High gastrin levels may help to explain the association between several conditions and osteoporosis, such as pernicious anemia, the use of proton pump inhibitors, and atrophic gastritis. This study aimed to determine whether administering …
View article: Editorial: Bridging the gap to molecular imaging and theranostics
Editorial: Bridging the gap to molecular imaging and theranostics Open
EDITORIAL article Front. Nucl. Med., 11 April 2024Sec. Radionuclide Therapy Volume 4 - 2024 | https://doi.org/10.3389/fnume.2024.1385097
View article: Optimizing PSMA scintigraphy for resource limited settings – a retrospective comparative study
Optimizing PSMA scintigraphy for resource limited settings – a retrospective comparative study Open
Background PSMA PET/CT is the most sensitive molecular imaging modality for prostate cancer (PCa), yet much of the developing world has little or no access to PET/CT. [ 99m Tc]Tc-PSMA scintigraphy (PS) is a cheaper and more accessible gamm…
View article: Case report: Peptide receptor radioligand therapy in metastatic pediatric neuroendocrine tumors
Case report: Peptide receptor radioligand therapy in metastatic pediatric neuroendocrine tumors Open
Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [ 68 Ga]Ga-DOTA-TATE for …
View article: Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease
Gallium-68 fibroblast activation protein inhibitor positron emission tomography in cardiovascular disease Open
Gallium-68 fibroblast activation protein inhibitor [( 68 Ga)Ga-FAPI] is a new radiopharmaceutical positioning itself as the preferred agent in patients with malignant tumours, competing with 2-Deoxy-2-[18F]fluoro-d-glucose [2-( 18 F)FDG] u…
View article: Biodosimetry, can it find its way to the nuclear medicine clinic?
Biodosimetry, can it find its way to the nuclear medicine clinic? Open
Personalised dosimetry based on molecular imaging is a field that has grown exponentially in the last decade due to the increasing success of Radioligand Therapy (RLT). Despite advances in imaging-based 3D dose estimation, the administered…
View article: Differences in Tumour Aggressiveness Based on Molecular Subtype and Race Measured by [18F]FDG PET Metabolic Metrics in Patients with Invasive Carcinoma of the Breast
Differences in Tumour Aggressiveness Based on Molecular Subtype and Race Measured by [18F]FDG PET Metabolic Metrics in Patients with Invasive Carcinoma of the Breast Open
Breast cancer in women of African descent tends to be more aggressive with poorer prognosis. This is irrespective of the molecular subtype. [18F]FDG PET/CT metrics correlate with breast cancer aggressiveness based on molecular subtype. Thi…
View article: Diagnostic Performance of 99mTc Bone Scintigraphy in the Staging of Prostate Cancer
Diagnostic Performance of 99mTc Bone Scintigraphy in the Staging of Prostate Cancer Open
Introduction: 99mTc MDP bone scintigraphy has utility in staging prostate cancer where access to more accurate modalities, such as PSMA ligand imaging, is limited by cost or lacking infrastructure.
View article: The Added Value of SPECT/CT in Pediatric Transplant Renography: A Case Report
The Added Value of SPECT/CT in Pediatric Transplant Renography: A Case Report Open
Introduction: Transplant renography with radionuclides has been in use for decades owing to its ability to assess renal perfusion, function, and drainage. An uncommon but significant complication post renal transplantation is a urinary lea…
View article: Utility of NETPET in Identification of Patients Suitable for Lu-177 DOTATATE Radionuclide Therapy
Utility of NETPET in Identification of Patients Suitable for Lu-177 DOTATATE Radionuclide Therapy Open
Introduction: The NETPET grading system is a quantitative method comparing somatostatin receptor expression with glucose metabolism on PET-CT to ascertain eligibility for PRRT. The aim was to assess the utility of the NETPET grading system…
View article: Designing a PET/CT Facility Integrated within the General Nuclear Medicine Department at Groote Schuur Hospital
Designing a PET/CT Facility Integrated within the General Nuclear Medicine Department at Groote Schuur Hospital Open
Introduction: Groote Schuur Hospital (GSH) was one of the only state hospitals in South Africa that did not have a PET/CT facility onsite that is required to support clinical work which includes planning for theragnostic applications.
View article: Theranostic Radiopharmaceuticals: A Universal Challenging Educational Paradigm in Nuclear Medicine
Theranostic Radiopharmaceuticals: A Universal Challenging Educational Paradigm in Nuclear Medicine Open
The field of nuclear medicine traces its origin to the accidental discovery and naming of radioactivity by Henri Becquerel and Marie Curie in 1896 and 1905. In March 1936, Hamilton and Stone in California used "radiosodium," the first arti…
View article: The Impact of PET/CT on Paediatric Oncology
The Impact of PET/CT on Paediatric Oncology Open
This review paper will discuss the use of positron emission tomography/computed tomography (PET/CT) in paediatric oncology. Functional imaging with PET/CT has proven useful to guide treatment by accurately staging disease and limiting unne…
View article: Renal cortical transit time as a predictor for pyeloplasty in pediatric patients with unilateral hydronephrosis
Renal cortical transit time as a predictor for pyeloplasty in pediatric patients with unilateral hydronephrosis Open
Majority of patients with unilateral hydronephrosis (HN) detected on ultrasound do not require pyeloplasty. The measurement of the cortical transit time (CTT) has been demonstrated by several authors to predict the need for patients who ma…
View article: Comparison of <sup>18</sup>F-Fluorodeoxyglucose positron emission tomography/computed tomography and conventional imaging for locally advanced breast cancer staging: A prospective study from a tertiary hospital cancer centre in the Western Cape
Comparison of <sup>18</sup>F-Fluorodeoxyglucose positron emission tomography/computed tomography and conventional imaging for locally advanced breast cancer staging: A prospective study from a tertiary hospital cancer centre in the Western Cape Open
Background: Breast cancer is the second most common cancer in adults and the most frequent cancer diagnosed in women. In South Africa, breast cancer accounts for 38.5% of cancers diagnosed in women. Since the presence, extent and location …
View article: The need for nationally accepted guidelines for undergraduate nuclear medicine teaching in MBChB programmes in South Africa
The need for nationally accepted guidelines for undergraduate nuclear medicine teaching in MBChB programmes in South Africa Open
According to the South African Health Professions Act No. 56 of 1974, specific skills outcomes of MBChB programmes are that a medical graduate must be able to utilise diagnostic aids, interpret findings and make diagnoses. Imaging techniqu…
View article: Renal Cortical Transit Time as a Predictor for Pyeloplasty in Paediatric Patients with Unilateral Hydronephrosis at the Red Cross War Memorial Children’s Hospital
Renal Cortical Transit Time as a Predictor for Pyeloplasty in Paediatric Patients with Unilateral Hydronephrosis at the Red Cross War Memorial Children’s Hospital Open
Background:
\nMajority of patients with unilateral hydronephrosis (HN) detected on ultrasound (US)
\ndo not require pyeloplasty. Indications for pyeloplasty are in patients with symptomatic
\nobstruction (recurrent flank pain), complicatio…