Stuart Oldham
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View article: Right time, right place: Heterochronicity shapes brain network formation
Right time, right place: Heterochronicity shapes brain network formation Open
Brain network formation unfolds on a non-uniform developmental timetable, with different cortical regions generating connections at different developmental phases. Generative network models (GNMs) aim to uncover the principles underpinning…
View article: Benchmarking overlapping community detection methods for applications in human connectomics
Benchmarking overlapping community detection methods for applications in human connectomics Open
Brain networks exhibit non-trivial modular organization, with groups of densely connected areas participating in specialized functions. Traditional community detection algorithms assign each node to one module, but this representation cann…
View article: Transmodal association hubs of the cerebral cortex: maps, models, and mechanisms
Transmodal association hubs of the cerebral cortex: maps, models, and mechanisms Open
Connectivity hubs of the human brain exert a major influence on function and are strongly concentrated within areas of transmodal association cortex. These areas play a central role in supporting abstract, multimodal cognition and also sho…
View article: Disentangling the influences of pre- and postnatal periods on human cortical microstructure
Disentangling the influences of pre- and postnatal periods on human cortical microstructure Open
During late gestation and early postnatal development a combination of intrinsic and extrinsic factors drive the maturation of the human cortex. This process is regionally heterogeneous, with cortical areas developing at different paces an…
View article: Transcriptomic divergence of network hubs in the prenatal human brain
Transcriptomic divergence of network hubs in the prenatal human brain Open
Connections in the human brain are not uniformly distributed; instead, a dense network of long-range projections converge on highly connected hub regions located in transmodal, paralimbic, and association cortices. Hub connectivity is stro…
View article: Benchmarking overlapping community detection methods for applications in human connectomics
Benchmarking overlapping community detection methods for applications in human connectomics Open
Brain networks exhibit non-trivial modular organization, with groups of densely connected areas participating in specialized functions. Traditional community detection algorithms assign each node to one module, but this representation cann…
View article: Coming up short: Generative network models fail to accurately capture long-range connectivity
Coming up short: Generative network models fail to accurately capture long-range connectivity Open
Generative network models (GNMs) have been proposed to identify the mechanisms/constraints that shape the organization of the connectome. These models parameterize the formation of interregional connections using a trade-off between connec…
View article: Geometric Constraints on the Architecture of Mammalian Cortical Connectomes
Geometric Constraints on the Architecture of Mammalian Cortical Connectomes Open
View article: Perinatal development of structural thalamocortical connectivity
Perinatal development of structural thalamocortical connectivity Open
Thalamocortical connections are crucial for relaying sensory information in the brain and facilitate essential functions including motor skills, emotion, and cognition. Emerging evidence suggests that thalamocortical connections are organi…
View article: Coming up short: generative network models fail to accurately capture long-range connectivity
Coming up short: generative network models fail to accurately capture long-range connectivity Open
Generative network models (GNMs) have been proposed to identify the mechanisms/constraints that shape the organisation of the connectome. These models parameterise the formation of inter-regional connections using a trade-off between conne…
View article: Molecular signatures of cortical expansion in the human foetal brain
Molecular signatures of cortical expansion in the human foetal brain Open
The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how th…
View article: White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis
White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis Open
View article: Hypothalamus Connectivity in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Hypothalamus Connectivity in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Open
Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling illness of unknown etiology. Increasing evidence suggests hypothalamic involvement in ME/CFS pathophysiology, which has rarely been explored using magnet…
View article: Multiscale heterogeneity of white matter morphometry in psychiatric disorders
Multiscale heterogeneity of white matter morphometry in psychiatric disorders Open
Background: Interindividual variability in neurobiological and clinical characteristics in mental illness is often overlooked by classical group mean case control studies. Studies using normative modelling to infer person specific deviatio…
View article: Author Correction: A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
Author Correction: A shifting role of thalamocortical connectivity in the emergence of cortical functional organization Open
View article: A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization Open
View article: White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis
White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis Open
Cannabis use disorder (CUD) is associated with adverse mental health effects, as well as social and cognitive impairment. Given prevalence rates of CUD are increasing, there is considerable efforts, and need, to identify prognostic markers…
View article: A shifting role of thalamocortical connectivity in the emergence of large-scale functional brain organization during early lifespan
A shifting role of thalamocortical connectivity in the emergence of large-scale functional brain organization during early lifespan Open
While cortical patterning has been a perennial research topic in neuroscience, the mechanism for its consequence, namely functional specialization at the macro scale, remains an open question in the human brain. Here, we focused on age-dep…
View article: Molecular signatures of cortical expansion in the human fetal brain
Molecular signatures of cortical expansion in the human fetal brain Open
The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. A growing catalogue of cells in the prenatal brain has revealed remarkable molecular diversity across cortical areas. 1,2…
View article: A phylogenetically-conserved axis of thalamocortical connectivity in the human brain
A phylogenetically-conserved axis of thalamocortical connectivity in the human brain Open
View article: Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis
Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis Open
Importance Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown. Objective …
View article: A phylogenetically-conserved axis of thalamocortical connectivity in the human brain
A phylogenetically-conserved axis of thalamocortical connectivity in the human brain Open
This is the data for the accompanying paper “A phylogenetically-conserved axis of thalamocortical connectivity in the human brain”. Further details can be found here
View article: Parameter estimation for connectome generative models: Accuracy, reliability, and a fast parameter fitting method
Parameter estimation for connectome generative models: Accuracy, reliability, and a fast parameter fitting method Open
Generative models of the human connectome enable in silico generation of brain networks based on probabilistic wiring rules. These wiring rules are governed by a small number of parameters that are typically fitted to individual connectome…
View article: Can hubs of the human connectome be identified consistently with diffusion MRI?
Can hubs of the human connectome be identified consistently with diffusion MRI? Open
Recent years have seen a surge in the use of diffusion MRI to map connectomes in humans, paralleled by a similar increase in processing and analysis choices. Yet these different steps and their effects are rarely compared systematically. H…
View article: Can hubs of the human connectome be identified consistently with diffusion MRI?
Can hubs of the human connectome be identified consistently with diffusion MRI? Open
Recent years have seen a surge in the use of diffusion MRI to map connectomes in humans, paralleled by a similar increase in processing and analysis choices. Yet these different steps and their effects are rarely compared systematically. H…
View article: A phylogenetically-conserved axis of thalamocortical connectivity in the human brain
A phylogenetically-conserved axis of thalamocortical connectivity in the human brain Open
The thalamus enables key sensory, motor, emotive, and cognitive processes via connections to the cortex. These projection patterns are traditionally considered to originate from discrete thalamic nuclei, however recent work showing gradien…
View article: Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis
Associations of cardiorespiratory fitness and exercise with brain white matter in healthy adults: A systematic review and meta-analysis Open
Magnetic resonance imaging (MRI) studies have revealed positive associations between brain structure and physical activity, cardiorespiratory fitness, and exercise (referred to here as PACE). While a considerable body of research has inves…
View article: Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease: the IMAGE-HD study
Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease: the IMAGE-HD study Open
The striatum is the principal site of disease pathology in Huntington’s disease and contains neural connections to numerous cortical brain regions. Studies examining abnormalities to neural connections find that white matter integrity is c…
View article: Modeling spatial, developmental, physiological, and topological constraints on human brain connectivity
Modeling spatial, developmental, physiological, and topological constraints on human brain connectivity Open
The complex connectivity of nervous systems is thought to have been shaped by competitive selection pressures to minimize wiring costs and support adaptive function. Accordingly, recent modeling work indicates that stochastic processes, sh…
View article: The relationship between fronto-striatal tractography and cortical morphometry changes in Huntington's Disease: Image-HD
The relationship between fronto-striatal tractography and cortical morphometry changes in Huntington's Disease: Image-HD Open
This paper aimed to investigate the relationship between cortical folding and white matter integrity changes in Huntington’s disease. Cortical morphometry and tractography changes in three gyral based regions of interest (i.e., precentral,…