Explanipedia

Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy Open

Stuart Prince, Miro Viitala, Riikka Sjöroos, Ábris Á. Bendes, Jenna H. Rannikko , et al. · 2025

Rationale: Clever-1 is a multifunctional scavenger receptor that promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. Its high expression correlates with resistance to immune checkpoint inhibitor…

Screening of homing and tissue-penetrating peptides by microdialysis and in vivo phage display Open

Toini Pemmari, Stuart Prince, Niklas Salonen, Kuldar Kõiv, Ulrike May , et al. · 2025

In vivo phage display is a method used for identification of organ- or disease-specific vascular homing peptides for targeted delivery of pharmaceutics. It is agnostic as to the nature and identity of the target molecules. The current in v…

Secreted Clever-1 Modulates T Cell Responses and Impacts Cancer Immunotherapy Efficacy Open

Stuart Prince, Miro Viitala, Riikka Sjöroos, Ábris Á. Bendes, Jenna H. Rannikko , et al. · 2024

Clever-1 functions as a scavenger and adhesion receptor, promoting tolerogenic activities in macrophages and subsets of endothelial cells, thereby contributing to cancer progression. High Clever-1 expression associates with resistance to i…

Epitope-specific antibody fragments block aggregation of AGelD187N, an aberrant peptide in gelsolin amyloidosis Open

Laura Leimu, Patrik Holm, Anna Gąciarz, Oskar Haavisto, Stuart Prince , et al. · 2024

Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase Open

Olli Huhtinen, Stuart Prince, Urpo Lamminmäki, Rune Salbo, Antti Kulmala · 2024

Author Correction: Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function Open

Horacio Maldonado, Bryan D. Savage, Harlan Barker, Ulrike May, Maria Vähätupa , et al. · 2024

Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function Open

Horacio Maldonado, Bryan D. Savage, Harlan Barker, Ulrike May, Maria Vähätupa , et al. · 2023

CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has inherent ability to promote wound healing: wounds close and re-epithelialise faster in CAR-tre…

Selection of biophysically favorable antibody variants using a modified Flp-In CHO mammalian display platform Open

Olli Huhtinen, Rune Salbo, Urpo Lamminmäki, Stuart Prince · 2023

Mammalian display enables the selection of biophysically favorable antibodies from a large IgG antibody library displayed on the plasma membrane of mammalian cells. We constructed and validated a novel mammalian display platform utilizing …

Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function Open

Bryan Savage, Horacio Maldonado, Ulrike May, Maria Vähätupa, Harlan Barker , et al. · 2022

CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has an inherent ability to promote wound healing; wounds close and re-epithelialise faster in CAR-…

Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies Open

João Q. Coentro, Ulrike May, Stuart Prince, John C. Zwaagstra, Olli Ritvos , et al. · 2021

Skin fibrosis still constitutes an unmet clinical need. Although pharmacological strategies are at the forefront of scientific and technological research and innovation, their clinical translation is hindered by the poor predictive capacit…

Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology Open

Aqsa Iqbal, Ulrike May, Stuart Prince, Tero A.H. Järvinen, Ahlke Heydemann · 2021

Muscular dystrophy is a progressively worsening and lethal disease, where accumulation of functionality-impairing fibrosis plays a key pathogenic role. Transforming growth factor-β1 (TGFβ1) is a central signaling molecule in the developmen…

Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa Open

Toini Pemmari, Larisa Ivanova, Ulrike May, Prakash Lingasamy, Allan Tobi , et al. · 2020

Systemic skin-selective therapeutics would be a major advancement in the treatment of diseases affecting the entire skin, such as recessive dystrophic epidermolysis bullosa (RDEB), which is caused by mutations in the COL7A1 gene and manife…

Assessment of Independent Child Trafficking Guardians: Regional Practice Co-ordinators: Final Report Open

Hannah Shrimpton, Roya Kamvar, Jonathan Harper, Samuel Gordon-Ramsay, James M Long , et al. · 2020

R‐Ras deficiency does not affect papain‐induced IgE production in mice Open

Laura Kummola, Zsuzsanna Ortutay, Maria Vähätupa, Stuart Prince, Hannele Uusitalo‐Järvinen , et al. · 2017

Introduction R‐Ras GTPase has recently been implicated in the regulation of immune functions, particularly in dendritic cell (DC) maturation, immune synapse formation, and subsequent T cell responses. Methods Here, we investigated the role…

Role of carbonic anhydrases in skin wound healing Open

Harlan Barker, Marleena Aaltonen, Peiwen Pan, Maria Vähätupa, Pirkka Kaipiainen , et al. · 2017

Heart and Lung Transplantation at Fiona Stanley Hospital - A New Centre's Experience Open

Charles Jenkinson, Dorian Wenzel, Stuart Prince, Christopher Merry, Karim Slimani , et al. · 2017

T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development Open

Maria Vähätupa, Saara Aittomäki, Zuzet Martínez Córdova, Ulrike May, Stuart Prince , et al. · 2016

Proprotein convertases (PCSK) have a critical role in the body homeostasis as enzymes responsible for processing precursor proteins into their mature forms. FURIN, the first characterized member of the mammalian PCSK family, is overexpress…

Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy Open

Maria Vähätupa, Stuart Prince, Suvi Vataja, Teija Mertimo, Marko Kataja , et al. · 2016

Our results suggest that R-Ras has a role in controlling retinal vessel maturation and stabilization in ischemic retinopathy and provides a potential target for pharmacologic manipulation to treat diabetic retinopathy.

Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist Open

Susana Frago, Ryan Nicholls, Madeleine Strickland, Jennifer Hughes, Christopher Williams , et al. · 2016

Significance During 150 million years of mammalian evolution, the membrane-bound mannose 6-phosphate receptor evolved high-affinity binding loops for insulin-like growth factor 2. It remains unknown whether this highly evolved ligand inter…

Systemically Administered, Target Organ-Specific Therapies for Regenerative Medicine Open

Tero A.H. Järvinen, Ulrike May, Stuart Prince · 2015

Growth factors and other agents that could potentially enhance tissue regeneration have been identified, but their therapeutic value in clinical medicine has been limited for reasons such as difficulty to maintain bioactivity of locally ap…

Resistance of R-Ras knockout mice to skin tumour induction Open

Ulrike May, Stuart Prince, Maria Vähätupa, Anni M. Laitinen, Katriina Nieminen , et al. · 2015

Decorin: A Growth Factor Antagonist for Tumor Growth Inhibition Open

Tero A.H. Järvinen, Stuart Prince · 2015

Decorin (DCN) is the best characterized member of the extracellular small leucine-rich proteoglycan family present in connective tissues, typically in association with or “decorating” collagen fibrils. It has substantial interest to clinic…

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