Su Chi Lim
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View article: ASSOCIATION BETWEEN ALBUMINURIA AND SLOW GAIT SPEED IN MALES WITH TYPE 2 DIABETES
ASSOCIATION BETWEEN ALBUMINURIA AND SLOW GAIT SPEED IN MALES WITH TYPE 2 DIABETES Open
OBJECTIVESChronic kidney disease is highly prevalent in older patients with type 2 diabetes (T2D). Albuminuria is a marker of vascular endothelial pathology that reflects increased inflammatory state of CKD. Such vascular pathology could c…
View article: <b>Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes</b>
<b>Association of plasma angiogenin with risk of incident end-stage kidney disease in individuals with type 2 diabetes</b> Open
We aim to investigate the association between plasma angiogenin and the risk of progression to end-stage kidney disease (ESKD) in Type 2 Diabetes (T2D) patients and attempted to infer the causal relationship between plasma angiogenin and c…
View article: Acute kidney injury predicts the risk of adverse cardio renal events and all cause death in southeast Asian people with type 2 diabetes
Acute kidney injury predicts the risk of adverse cardio renal events and all cause death in southeast Asian people with type 2 diabetes Open
Patients with diabetes are susceptible to acute kidney injury (AKI) as compared to counterparts without diabetes. However, data on the long-term clinical outcome of AKI specifically in people with diabetes are still scarce. We sought to st…
View article: Incident heart failure and the subsequent risk of progression to end stage kidney disease in individuals with type 2 diabetes
Incident heart failure and the subsequent risk of progression to end stage kidney disease in individuals with type 2 diabetes Open
Background Diabetic kidney disease is an established risk factor for heart failure. However, the impact of incident heart failure on the subsequent risk of renal failure has not been systematically assessed in diabetic population. We sough…
View article: ASSOCIATION BETWEEN GLYCEMIC VARIABILITY AND LOWER COGNITIVE FUNCTION, MEDIATED BY ARTERIAL STIFFNESS, IN ASIANS WITH TYPE 2 DIABETES
ASSOCIATION BETWEEN GLYCEMIC VARIABILITY AND LOWER COGNITIVE FUNCTION, MEDIATED BY ARTERIAL STIFFNESS, IN ASIANS WITH TYPE 2 DIABETES Open
INTRODUCTIONGlycemic variability involves deleterious cellular processes due to hyperglycemic spikes and hypoglycemic troughs. It is a known predictor of renal, retinal, and cardiovascular complications in type 2 diabetes (T2D). However, i…
View article: Longitudinal profiling and tracking stability in the Singapore study of macro-angiopathy and microvascular reactivity in type 2 diabetes cohort
Longitudinal profiling and tracking stability in the Singapore study of macro-angiopathy and microvascular reactivity in type 2 diabetes cohort Open
Introduction The Singapore Study of Macro-Angiopathy and microvascular Reactivity in Type 2 Diabetes (SMART2D) is a prospective cohort study which was started in 2011 to investigate the effect of risk factors on vascular function and diabe…
View article: Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes
Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: We sought to study the associations between plasma metabolites in tryptophan-kynurenine pathway and the risk of progression to end stage kidney disease (ESKD) in patients with type 2 diabetes. Design and Methods: Plasma tryptoph…
View article: Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes Open
OBJECTIVE We sought to study the associations between plasma metabolites in the tryptophan-kynurenine pathway and the risk of progression to end-stage kidney disease (ESKD) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Plas…
View article: Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes
Plasma tryptophan- kynurenine pathway metabolites and risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: We sought to study the associations between plasma metabolites in tryptophan-kynurenine pathway and the risk of progression to end stage kidney disease (ESKD) in patients with type 2 diabetes. Design and Methods: Plasma tryptoph…
View article: Deep learning algorithms to detect diabetic kidney disease from retinal photographs in multiethnic populations with diabetes
Deep learning algorithms to detect diabetic kidney disease from retinal photographs in multiethnic populations with diabetes Open
Objective To develop a deep learning algorithm (DLA) to detect diabetic kideny disease (DKD) from retinal photographs of patients with diabetes, and evaluate performance in multiethnic populations. Materials and methods We trained 3 models…
View article: 12-OR: Urine Lactate Is a Disease Biomarker for Diabetic Kidney Disease
12-OR: Urine Lactate Is a Disease Biomarker for Diabetic Kidney Disease Open
As lactate (LA) elevation is associated with mitochondrial dysfunction, we examined the role of LA in diabetic kidney disease (DKD) progression. Urine LA (ULA) was measured in patients with type 2 diabetes (T2D) in three independent cohort…
View article: Association between lower phase angle and chronic kidney disease progression in type 2 diabetes patients
Association between lower phase angle and chronic kidney disease progression in type 2 diabetes patients Open
Introduction: Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is the angle of vector determined by the body’s resistance and reactance. It indicates cellular integrity and hydration status. Though extracellular volu…
View article: Association between self-care and chronic kidney disease in patients with type 2 diabetes mellitus
Association between self-care and chronic kidney disease in patients with type 2 diabetes mellitus Open
Chronic kidney disease (CKD) is one of the key complications occurring in 25-40% of patients with type 2 diabetes mellitus (T2DM). 1 Our earlier study also showed that CKD was present in 53% of patients with T2DM recruited from a secondary…
View article: Short-term Weight Trajectory of Severely Obese Individuals With and Without Pathogenic Satiety-Regulation Melanocortin 3/4 Receptor (MC3/4R) Mutations From a Multi-ethnic Asian Large Bariatric Surgery Program
Short-term Weight Trajectory of Severely Obese Individuals With and Without Pathogenic Satiety-Regulation Melanocortin 3/4 Receptor (MC3/4R) Mutations From a Multi-ethnic Asian Large Bariatric Surgery Program Open
The melanocortin (3 or 4) receptor (MC3/4R) is involved in regulating satiety and body weight. Therefore, pathogenic mutation in MC3/4R is associated with severe obesity, for which bariatric surgery is one of the treatment options. However…
View article: Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is recently identified as an amplifier of transforming growth factor (TGF)- beta- induced kidney fibrosis in animal models. We aim to study whether urine LRG1 is associated with risk …
View article: Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is recently identified as an amplifier of transforming growth factor (TGF)- beta- induced kidney fibrosis in animal models. We aim to study whether urine LRG1 is associated with risk …
View article: Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes
Urine leucine-rich alpha-2 glycoprotein 1 (LRG1) predicts the risk for progression to end stage kidney disease in patients with type 2 diabetes Open
Objective: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is recently identified as an amplifier of transforming growth factor (TGF)- beta- induced kidney fibrosis in animal models. We aim to study whether urine LRG1 is associated with risk …
View article: Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes
Urine Leucine-Rich α-2 Glycoprotein 1 (LRG1) Predicts the Risk of Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes Open
OBJECTIVE Leucine-rich α-2 glycoprotein 1 (LRG1) was recently identified as an amplifier of transforming growth factor-β (TGF-β)–induced kidney fibrosis in animal models. We aimed to study whether urine LRG1 is associated with risk of prog…
View article: HIGHER FOLLICLE STIMULATING HORMONE WAS ASSOCIATED WITH POOR HANDGRIP STRENGTH AND GAIT SPEED IN OLDER MEN WITH TYPE 2 DIABETES
HIGHER FOLLICLE STIMULATING HORMONE WAS ASSOCIATED WITH POOR HANDGRIP STRENGTH AND GAIT SPEED IN OLDER MEN WITH TYPE 2 DIABETES Open
OBJECTIVESSarcopenia is characterised by age-related loss of muscle mass, strength and physical performance. It is accelerated in type 2 diabetes mellitus(T2DM). Higher follicle-stimulating hormone(FSH) reportedly contributes to muscle mas…
View article: IMPACT OF LIVER STEATOSIS ON GLYCEMIC IMPROVEMENT AT SIX MONTHS AFTER BARIATRIC SURGERY
IMPACT OF LIVER STEATOSIS ON GLYCEMIC IMPROVEMENT AT SIX MONTHS AFTER BARIATRIC SURGERY Open
OBJECTIVESNon-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and increases the risk of type 2 diabetes (T2D) development. This pilot prospective study aimed to determine whether the severity of liver steatosis/ f…
View article: ASSOCIATION BETWEEN ELEVATED PHASE ANGLE AND REDUCED RISK OF CHRONIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES
ASSOCIATION BETWEEN ELEVATED PHASE ANGLE AND REDUCED RISK OF CHRONIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES Open
OBJECTIVESPhase angle (PhA) is a bioelectrical impedance analysis parameter defined as the angle of the vector formed by the body’s resistance and reactance. It indicates nutritional status, with higher levels signifying healthier cell mem…
View article: ATHEROGENIC INDEX OF PLASMA, MEDIATED BY PIGMENT EPITHELIUM-DERIVED FACTOR IS ASSOCIATED WITH CHRONIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES
ATHEROGENIC INDEX OF PLASMA, MEDIATED BY PIGMENT EPITHELIUM-DERIVED FACTOR IS ASSOCIATED WITH CHRONIC KIDNEY DISEASE PROGRESSION IN TYPE 2 DIABETES Open
OBJECTIVESAtherogenic index of plasma (AIP) is a novel marker of atherosclerosis and cardiovascular disease. Its role in chronic kidney disease (CKD) progression is unknown. Pigment epithelium-derived factor (PEDF) has anti-oxidant, anti-a…
View article: ASSOCIATION OF CIRCULATING HYPOXIA- INDUCIBLE FACTOR 1 ALPHA WITH TYPE 2 DIABETES IN INDIVIDUALS WITH SEVERE OBESITY
ASSOCIATION OF CIRCULATING HYPOXIA- INDUCIBLE FACTOR 1 ALPHA WITH TYPE 2 DIABETES IN INDIVIDUALS WITH SEVERE OBESITY Open
OBJECTIVESObesity and type 2 diabetes (T2D) are often attributed to hypoxia. Adaptive responses to hypoxia are regulated by hypoxia-inducible factor 1 α (HIF1α). The role of hyperglycemia in mediating HIF1α expression and activity remains …
View article: Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in Type 2 diabetes – mediation by pigment epithelium-derived factor
Triglyceride-glucose index is prospectively associated with chronic kidney disease progression in Type 2 diabetes – mediation by pigment epithelium-derived factor Open
Background Triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance. Its role in chronic kidney disease (CKD) progression in Type 2 Diabetes Mellitus (T2DM) is unclear. We investigated the association between TyG index …
View article: Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes
Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes Open
Aims/hypothesis We sought to subtype South East Asian patients with type 2 diabetes by de novo cluster analysis on clinical variables, and to determine whether the novel subgroups carry distinct genetic and lipidomic features as well as di…
View article: Genetic Risk Score for Plasma Uric Acid Levels Is Associated With Early Rapid Kidney Function Decline in Type 2 Diabetes
Genetic Risk Score for Plasma Uric Acid Levels Is Associated With Early Rapid Kidney Function Decline in Type 2 Diabetes Open
Context Observational studies have shown that elevated uric acid (UA) is associated with chronic kidney disease (CKD). However, whether the relationship is causal remains unclear. Objective To determine the association of plasma UA and inc…
View article: Insulin Allergy to Detemir Followed by Rapid Onset of Diabetic Ketoacidosis: A Case Report and Literature Review
Insulin Allergy to Detemir Followed by Rapid Onset of Diabetic Ketoacidosis: A Case Report and Literature Review Open
The management of diabetes mellitus in an insulin-dependent patient is challenging in the setting of concomitant antibody-mediated-insulin hypersensitivity. We report a case of a 62-year-old woman with pre-existing type 2 diabetes mellitus…