Explanipedia

254. QUANTIFYING PERIOPERATIVE RISKS FOR ANTIREFLUX AND HIATUS HERNIA SURGERY: A MULTICENTER COHORT STUDY OF 4301 PATIENTS Open

David Liu, Darren Wong, Su Kah Goh, Aly Fayed, Sean Stevens , et al. · 2024

Background Predicting perioperative risks for fundoplication and hiatus hernia repair will inform treatment decision-making, hospital resource allocation, and benchmarking. However, available risk calculators do not account for hernia anat…

T cell factor 1 (TCF-1) defines T cell differentiation in colorectal cancer Open

Kelly Tran, Anita Kumari, Dinesh Raghu, Daniel Cox, Su Kah Goh , et al. · 2024

Postoperative anaemia increases unplanned readmission: an international prospective cohort study of patients undergoing major abdominal surgery Open

Kenneth J Macpherson, Kenneth J Macpherson, Ane Abad‐Motos, Vinicio Mosca, Ruth Blanco Colino , et al. · 2024

Point‐of‐care detection of fibrosis in liver transplant surgery using near‐infrared spectroscopy and machine learning Open

Varun Sharma, John A. Adegoke, Alexander Green, Su Kah Goh, Xiuwen Peng , et al. · 2023

Introduction Visual assessment and imaging of the donor liver are inaccurate in predicting fibrosis and remain surrogates for histopathology. We demonstrate that 3‐s scans using a handheld near‐infrared‐spectroscopy (NIRS) instrument can i…

Graft-derived cfDNA Monitoring in Plasma and Bile During Normothermic Machine Perfusion in Liver Transplantation Is Feasible and a Potential Tool for Assessing Graft Viability Open

Daniel Cox, Eunice Lee, Boris Ka Leong Wong, Tess McClure, Fan Zhang , et al. · 2023

Background. Ex vivo normothermic machine perfusion (NMP) is an organ preservation technique that enables an extended assessment of graft suitability before liver transplantation (LT). Established monitoring protocols used during NMP vary s…

Migrated Laparoscopic Surgical Clips Causing Acute Cholangitis 32 Years After Laparoscopic Cholecystectomy Open

Yijie Yin, Su Kah Goh, Reizal Mohd Rosli, John‐Edwin Thomson, Chuan Tan · 2023

Dual Antiplatelet Therapy Prior to Percutaneous Coronary Intervention for Acute Coronary Syndrome: Prevalence and Clinical Outcomes Open

Su Kah Goh, Diem Dinh, Angela Brennan, R. Batchelor, Dion Stub , et al. · 2023

Graft-Derived Cell-Free DNA Quantification following Liver Transplantation Using Tissue-Specific DNA Methylation and Donor-Specific Genotyping Techniques: An Orthogonal Comparison Study Open

Daniel Cox, Tess McClure, Fan Zhang, Boris Ka Leong Wong, Adam Testro , et al. · 2023

Background: Graft-derived cell-free DNA (gdcfDNA) analysis has shown promise as a non-invasive tool for monitoring organ health following solid organ transplantation. A number of gdcfDNA analysis techniques have been described; however, th…

Effect of timing of perioperative chemical thromboprophylaxis on thromboembolic, bleeding, and other complications during and after antireflux surgery: multicentre cohort study Open

David S. Liu, Darren Wong, Su Kah Goh, David I. Watson, Enoch Wong , et al. · 2023

Background Although guidelines recommend the use of perioperative chemical thromboprophylaxis for antireflux surgery, the optimal timing for its initiation is unknown. The aim of this study was to investigate whether perioperative timing o…

Perforated duodenal diverticulum: protecting the ampulla through the imbrication technique of repair Open

Zachary Bunjo, Su Kah Goh, Hong Lee, Chuan Tan · 2023

Duodenal diverticula are the most common type of small bowel diverticula. The pathogenesis remains unclear but it is hypothesised that raised intraluminal pressure, inflammation and/or intestinal dysmotility increases the risk of mucosa an…

Laparoscopic choledochoscopy for choledocholithiasis is possible in the anatomical anomaly of left gallbladder Open

Peter Kaldas, Su Kah Goh, Laurence Weinberg, Russell Hodgson · 2022

Laparoscopic cholecystectomy (LC) is more challenging in the anatomical variation of left-sided gallbladder with the anomaly also highly related to biliary anomalies. Therefore, there has been a reluctance to operate close to the common bi…

Evaluating DNA recovery efficiency following bisulphite modification from plasma samples submitted for cell-free DNA methylation analysis Open

Daniel Cox, Boris Ka Leong Wong, Eunice Lee, Adam Testro, Vijayaragavan Muralidharan , et al. · 2022

The detection of methylated templates in cell-free DNA (cfDNA) is increasingly recognized as a valuable, non-invasive tool for diagnosis, monitoring and prognostication in a range of medical contexts. The importance of controlling pre-anal…

Incidental finding of a recurrent Bockdalek hernia with an intra-thoracic kidney Open

Russell Hodgson, Yasir Hasan, Su Kah Goh · 2022

Incidental finding of a recurrent Bockdalek hernia with an intrathoracic kidneyBockdalek hernia is a rare type of congenital diaphragmatic hernia which was firstly described by Vincent Alexander Bockdalek in 1848. [1]The hernia sac is more…

Pancreatic mass in a patient undergoing immunotherapy for metastatic renal cell carcinoma: dilemmas in management Open

Su Kah Goh, Daniel Cox, Andrew Weickhardt, Vijayaragavan Muralidharan, Marcos V. Perini · 2021

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Intrahepatic migration of pancreatic stent after pancreaticoduodenectomy: percutaneous cholangioscopic retrieval is feasible Open

Su Kah Goh, Hong Kuan Kok, Nezor Houli · 2021

Transanastomotic stents are often used in pancreaticoduodenectomy to maintain ductal patency and support the healing of anastomoses. This is widely performed, with a view of minimising postoperative pancreatic fistulas.[1 2][1] The use of …

A Synthetic DNA Construct to Evaluate the Recovery Efficiency of Cell-Free DNA Extraction and Bisulfite Modification Open

Su Kah Goh, Daniel Cox, Boris Ka Leong Wong, Ashan Musafer, Tom Witkowski , et al. · 2021

Background Despite improvements in the genetic and epigenetic analysis of cell-free DNA (cfDNA), there has been limited focus on assessing the preanalytical variables of recovery efficiency following cfDNA extraction and bisulfite modifica…

Donor-specific cell-free DNA as a biomarker in liver transplantation: A review Open

Tess McClure, Su Kah Goh, Daniel Cox, Vijayaragavan Muralidharan, Alexander Dobrovic , et al. · 2020

Due to advances in modern medicine, liver transplantation has revolutionised the prognosis of many previously incurable liver diseases. This progress has largely been due to advances in immunosuppressant therapy. However, despite the judic…

Surgical Outpatient Study: characterizing the educational experience of outpatient clinics for surgical trainees Open

Su Kah Goh, Nagendra N. Dudi‐Venkata, Bob Zhou, Daniel Ng, David S. Liu , et al. · 2020

Elevated Plasma Levels of Cell‐Free DNA During Liver Transplantation Are Associated With Activation of Coagulation Open

Osamu Yoshino, Vijayaragavan Muralidharan, Alexander Dobrovic, Su Kah Goh · 2019

Potential conflict of interest: Nothing to report. To the Editor: Cell‐free DNA (cfDNA) is emerging as an immunomodulator in numerous medical conditions, including malignancy, chronic inflammatory diseases, trauma, sepsis, and organ transp…

The Measurement of Donor-Specific Cell-Free DNA Identifies Recipients With Biopsy-Proven Acute Rejection Requiring Treatment After Liver Transplantation Open

Su Kah Goh, Hongdo Do, Adam Testro, J Pavlović, Angela Vago , et al. · 2019

Background. Assessment of donor-specific cell-free DNA (dscfDNA) in the recipient is emerging as a noninvasive biomarker of organ rejection after transplantation. We previously developed a digital polymerase chain reaction (PCR)-based appr…

Development of a cell-free DNA methodology to assess organ rejection after liver transplantation Open

Su Kah Goh · 2019

Dilemmas and limitations interpreting carbohydrate antigen 19-9 elevation after curative pancreatic surgery: A case report Open

Grace Gold, Su Kah Goh, Christopher Christophi, Vijayaragavan Muralidharan · 2018

Emergency presentations of acute biliary pain: changing patterns of management in a tertiary institute Open

Daniel Cox, Jonathan Fong, Chon Hann Liew, Su Kah Goh, Michael Yeoh , et al. · 2018

Background Acute biliary pain is the most common presentation of gallstone disease. Untreated patients risk recurrent pain, cholecystitis, obstructive jaundice, pancreatitis and multiple hospital presentations. We examine the outcome of im…

Use of indocyanine green dye clearance in a patient with liver cirrhosis undergoing hepatectomy: a clinical image Open

Laurence Weinberg, Callum Robinson, Su Kah Goh, Vijayragavan Muralidharan · 2018

Indocyanine green (ICG) is a water-soluble, non-toxic tricarbocyanine dye extracted exclusively from the hepatic parenchyma. Measurement of ICG clearance using pulse spectrophotometry is a simple, reproducible and non-invasive test, easily…

Adapting an Established Clinical Chemistry Quality Control Measure for Droplet Generation Performance in Digital PCR Open

Su Kah Goh, Boris Ka Leong Wong, Vijayaragavan Muralidharan, Christopher Christophi, Hongdo Do , et al. · 2018

To the Editor: Droplet digital PCR (ddPCR)1 is an emerging platform that is being increasingly adopted by clinical laboratories. The partitioning of a PCR reaction into discrete droplets enables the accurate detection and quantification o…

Fresh Frozen Plasma Transfusion Can Confound the Analysis of Circulating Cell-Free DNA Open

Su Kah Goh, Vijayaragavan Muralidharan, Christopher Christophi, Alexander Dobrovic · 2018

To the Editor: Advances in DNA detection methodologies have enabled the accurate assessment of circulating cell-free DNA (cfDNA).1 In transplantation, the quantification of donor-specific cfDNA (dscfDNA) can guide the noninvasive diagnosi…

Laparoscopic treatment of a patent ductus venosus and the use of indocyanine green to monitor perioperative hepatic function Open

Marcos V. Perini, Graham Starkey, Su Kah Goh, Georgina Riddiough, Christopher Christophi · 2018

Patent ductus venosus (PDV) is an uncommon but important congenital portocaval shunt that can lead to numerous complications if untreated. This case describes the successful management of a 17-year-old male with symptomatic PDV. Dop…

Salmonella typhimurium: a rare cause of mesh-related infection Open

Ankur Sidhu, Su Kah Goh, Eunice Lee, Christopher Christophi, Marcos V. Perini · 2017

The use of mesh in the management of abdominal wall hernias has significantly reduced the incidences of hernia recurrences. The placement of synthetic meshes to reinforce the abdominal wall is not without caveats. Synthetic meshes are asso…

Demystifying a thickened and calcified gall bladder in the era of multimodality imaging Open

Su Kah Goh, Anthony Upton, Christopher Christophi, Vijayaragavan Muralidharan · 2017

A 74-year-old woman presented with a 6-month history of significant postprandial nausea and mild abdominal discomfort. She was fit and well with a surgical history of appendicectomy. Routine blood tests including full blood examination an…

Erratum to non-homologous end-joining protein expression screen from radiosensitive cancer patients yields a novel DNA double strand break repair phenotype Open

Michael J. McKay, Su Kah Goh, Jeremy N. McKay, Michael Chao, Timothy M. McKay · 2017

Non-homologous end-joining protein expression screen from radiosensitive cancer patients yields a novel DNA double strand break repair phenotypeIn the article entitled "Non-homologous end-joining protein expression screen from radiosensiti…

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