Subbiah Jeeva
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View article: Effect of Seasonal Influenza Vaccines on Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Ferrets
Effect of Seasonal Influenza Vaccines on Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Ferrets Open
Highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b viruses have infected >1,000 herds of dairy cattle and hundreds of poultry flocks in the United States since the beginning of 2024. Seventy human cases have been reported during that…
View article: Machine Learning-Based Analysis of BMI, Tobacco Use and Oral Health Outcomes Among Chennai Construction Workers: Insights for Targeted Interventions
Machine Learning-Based Analysis of BMI, Tobacco Use and Oral Health Outcomes Among Chennai Construction Workers: Insights for Targeted Interventions Open
Background: This study investigates the complex relationship between Body Mass Index (BMI), tobacco consumption and oral health status among construction workers in Chennai, India. Using a neural network model, the study aims to identify s…
View article: Development of FRET-based cap-snatching endonuclease assay
Development of FRET-based cap-snatching endonuclease assay Open
The order Bunyavirales consists of over 300 species of segmented, negative-strand RNA viruses. These viruses have a tri-segmented genome (S, M, and L segments) that encodes the nucleocapsid protein (N protein), glycoprotein precursor, and …
View article: Non-neutralizing immune-mediated cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Non-neutralizing immune-mediated cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets Open
Current influenza vaccine based on hemagglutinin (HA) immunity is not effective in providing cross protection against circulating variants and new pandemic viruses. In prior studies, we developed universal influenza vaccine candidates of m…
View article: Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination
Heterologous Prime-Boost Vaccination with Inactivated Influenza Viruses Induces More Effective Cross-Protection than Homologous Repeat Vaccination Open
With concerns about the efficacy of repeat annual influenza vaccination, it is important to better understand the impact of priming vaccine immunity and develop an effective vaccination strategy. Here, we determined the impact of heterolog…
View article: Clinicopathological factors and multimodality treatment for nonsmall cell lung carcinoma in a government tertiary care center – A benchmarking approach
Clinicopathological factors and multimodality treatment for nonsmall cell lung carcinoma in a government tertiary care center – A benchmarking approach Open
BACKGROUND: Lung carcinoma is the leading cause of death due to cancer worldwide. The most common histology among lung cancer is nonsmall cell carcinoma lung (84%). Majority of nonsmall cell lung cancer (NSCLC) in India comes under stage I…
View article: Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice Open
View article: Synthesis of silver nanoparticles from natural derived embelin compound and their uses in mercury degradation under solar light
Synthesis of silver nanoparticles from natural derived embelin compound and their uses in mercury degradation under solar light Open
The present study deals with the isolation of embelin compound from Embelia ribes (Burm f). The isolated compounds were confirmed by UV/Vis spectrophotometer, 1 H NMR and 13 C NMR spectra. In absorption at 275 nm in UV/Vis spectra, peak ra…
View article: Spectrum of paediatric malignancies and treatment in COVID era – Our institutional experience
Spectrum of paediatric malignancies and treatment in COVID era – Our institutional experience Open
View article: Anterior mediastinal germcell tumor with brain metastasis in a child – A case report
Anterior mediastinal germcell tumor with brain metastasis in a child – A case report Open
View article: Unraveling the superior vena cava syndrome conundrum in lung cancer patients, a retrospective multivariate analysis – A tertiary care center venture
Unraveling the superior vena cava syndrome conundrum in lung cancer patients, a retrospective multivariate analysis – A tertiary care center venture Open
BACKGROUND: Need to address superior vena cava syndrome (SVCS) is essential since SVCS has the potential to be fatal if not treated as an emergency. MATERIALS AND METHODS: Forty histologically confirmed patients with SVCS due to lung cance…
View article: Anterior mediastinal germcell tumor with brain metastasis in a child – A case report
Anterior mediastinal germcell tumor with brain metastasis in a child – A case report Open
View article: Protective Immunity Induced by Immunization with Baculovirus, Virus-like Particle, and Vaccinia Virus Expressing the AMA1 of Plasmodium berghei
Protective Immunity Induced by Immunization with Baculovirus, Virus-like Particle, and Vaccinia Virus Expressing the AMA1 of Plasmodium berghei Open
Heterologous prime–boost immunization regimens using various vaccine platforms demonstrated promising results against infectious diseases. Here, mice were sequentially immunized with the recombinant baculovirus (rBV), virus-like particle (…
View article: Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle
Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle Open
Annual influenza vaccination is recommended to update the variable hemagglutinin antigens. Here, we first designed a virus-like particle (VLP) displaying consensus multi-neuraminidase (NA) subtypes (cN1, cN2, B cNA) and M2 ectodomain (M2e)…
View article: Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination
Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination Open
Adjuvants can increase the magnitude and durability of the immune response generated by the vaccine antigen. Aluminum salts (Alum) remain the main adjuvant licensed for human use. A few new adjuvants have been licensed for use in human vac…
View article: Impact of hemagglutination activity and M2e immunity on conferring protection against influenza viruses
Impact of hemagglutination activity and M2e immunity on conferring protection against influenza viruses Open
View article: A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine
A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine Open
View article: Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice
Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice Open
View article: Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes
Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes Open
View article: Drug resistance in Candida albicans isolates and related changes in the structural domain of Mdr1 protein
Drug resistance in Candida albicans isolates and related changes in the structural domain of Mdr1 protein Open
The investigation proved that the isolated C. albicans from TB patients are significantly resistant to the action of six drugs. The molecular changes in MDR1 genes showed differences in seven nucleotide base pairs that interfered with the …
View article: An Update on mRNA-Based Viral Vaccines
An Update on mRNA-Based Viral Vaccines Open
With the success of COVID-19 vaccines, newly created mRNA vaccines against other infectious diseases are beginning to emerge. Here, we review the structural elements required for designing mRNA vaccine constructs for effective in vitro syn…
View article: Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome
Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease 2019 (COVID-19) pandemic. A strong correlation has been demonstrated between worse COVID-19 outcomes, aging, and metabolic syndrome (MetS…
View article: Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice
Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be expanding the pandemic disease across the globe. Although SARS-CoV-2 vaccines were rapidly developed and approved for emergency use of vaccination in humans, supp…
View article: Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin
Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin Open
View article: Recombinant Live Attenuated Influenza Virus Expressing Conserved G-Protein Domain in a Chimeric Hemagglutinin Molecule Induces G-Specific Antibodies and Confers Protection against Respiratory Syncytial Virus
Recombinant Live Attenuated Influenza Virus Expressing Conserved G-Protein Domain in a Chimeric Hemagglutinin Molecule Induces G-Specific Antibodies and Confers Protection against Respiratory Syncytial Virus Open
Respiratory syncytial virus (RSV) is one of the most important pathogens causing significant morbidity and mortality in infants and the elderly. Live attenuated influenza vaccine (LAIV) is a licensed vaccine platform in humans and it is kn…
View article: TBK1 regulates regeneration of pancreatic β-cells
TBK1 regulates regeneration of pancreatic β-cells Open
View article: Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope
Cross protection by inactivated recombinant influenza viruses containing chimeric hemagglutinin conjugates with a conserved neuraminidase or M2 ectodomain epitope Open
View article: Adjuvant effects of killed Lactobacillus casei DK128 on enhancing T helper type 1 immune responses and the efficacy of influenza vaccination in normal and CD4-deficient mice
Adjuvant effects of killed Lactobacillus casei DK128 on enhancing T helper type 1 immune responses and the efficacy of influenza vaccination in normal and CD4-deficient mice Open
View article: Antigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles
Antigenicity and immunogenicity of unique prefusion-mimic F proteins presented on enveloped virus-like particles Open
View article: The efficacy of inactivated split respiratory syncytial virus as a vaccine candidate and the effects of novel combination adjuvants
The efficacy of inactivated split respiratory syncytial virus as a vaccine candidate and the effects of novel combination adjuvants Open