Subha Sen
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View article: TIM3 and TIGIT-expressing CD4 T cells are impacted by kidney transplantation and associated with risk of infection
TIM3 and TIGIT-expressing CD4 T cells are impacted by kidney transplantation and associated with risk of infection Open
Introduction Older kidney transplant patients experience higher rates of infection compared with younger transplant patients suggesting the impact of age-associated immune dysfunction. However, little is known about the impact of immunosup…
View article: Cytomegalovirus-associated CD57 + KLRG1 + CD8 + TEMRA T cells are associated with reduced risk of CMV viremia in kidney transplantation and chronic allograft dysfunction in lung transplantation
Cytomegalovirus-associated CD57 + KLRG1 + CD8 + TEMRA T cells are associated with reduced risk of CMV viremia in kidney transplantation and chronic allograft dysfunction in lung transplantation Open
Cytomegalovirus (CMV) infection threatens outcomes across solid organ transplantation, but organ-specific differences in CMV immunity are incompletely understood. We investigated whether lung and kidney CMV infection drove similar immune p…
View article: Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation
Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation Open
Introduction Cytomegalovirus (CMV) viremia remains a major contributor to clinical complications in solid organ transplant (SOT) patients, including organ injury, morbidity and mortality. Given their critical role in antiviral defense, CD8…
View article: Myeloid spatial and transcriptional molecular signature of ischemia-reperfusion injury in human liver transplantation
Myeloid spatial and transcriptional molecular signature of ischemia-reperfusion injury in human liver transplantation Open
Background: Ischemia-reperfusion injury (IRI) is a significant clinical concern in liver transplantation, with a key influence on short-term and long-term allograft and patient survival. Myeloid cells trigger and sustain tissue inflammatio…
View article: Plasma proteome perturbation for CMV DNAemia in kidney transplantation
Plasma proteome perturbation for CMV DNAemia in kidney transplantation Open
Background Cytomegalovirus (CMV) infection, either de novo or as reactivation after allotransplantation and chronic immunosuppression, is recognized to cause detrimental alloimmune effects, inclusive of higher susceptibility to graft rejec…
View article: Plasma Proteome Perturbation for CMV DNAemia in Kidney Transplantation
Plasma Proteome Perturbation for CMV DNAemia in Kidney Transplantation Open
Background Cytomegalovirus (CMV) infection, either de novo or as reactivation after allotransplantation and chronic immunosuppression, is recognized to cause detrimental alloimmune effects, inclusive of higher susceptibility to graft rejec…
View article: Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients
Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients Open
Significance Memory-like NK cells (NKG2C + CD57 + FcεRIγ – ) are established during CMV infection. Here, mass cytometry tracked the in vivo kinetics of CMV-induced memory NK cells generation and identified a unique subset of NKG2C + CD57 +…
View article: NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant
NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant Open
CMV is one of the most problematic pathogens in the immunocompromised host after solid organ and stem cell transplantation, increasing morbidity and mortality risk, and graft loss. Approaches for improved understanding and subsequent harne…
View article: Withdrawal: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice.
Withdrawal: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. Open
VOLUME 279 (2004) PAGES 20422–20434 This article has been withdrawn by Sagartirtha Sarkar, Douglas W. Leaman, Parames Sil, Annitta Morehead, Debabrata Mukherjee, Joe Hollyfield, and Subha Sen. Sudhiranjan Gupta, David Young, Norman Ratliff…
View article: Expression of Concern: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice.
Expression of Concern: Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. Open
Cardiac Overexpression of Myotrophin Triggers Myocardial Hypertrophy and Heart Failure in Transgenic MiceJournal of Biological ChemistryVol. 279Issue 19PreviewCardiac hypertrophy and heart failure remain leading causes of death in the Unit…
View article: PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5
PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5 Open
Th17 cells are a class of Th cells that secrete IL-17 and mediate pathogenic immunity responsible for autoimmunity including experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis. Retinoic acid–related orphan rece…
View article: TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner
TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner Open
T cell factor 1 (TCF-1) is expressed in both developing and mature T cells and has been shown to restrain mature T cell–mediated Th17 responses by inhibiting IL-17 expression. However, it is not clear when TCF-1 is required in vivo to rest…
View article: SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner
SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate RORγt activity in a PKC-θ–dependent manner Open
Significance Poor understanding of the mechanisms responsible for the development of IL-17 + and Foxp3 + cells prevents the development of potent clinical treatments to boost protective Th17 immunity and repress the pathogenic Th17 respons…
View article: Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt
Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt Open
Transcription factor retinoid acid–related orphan receptor (ROR)γt transcriptionally regulates the genes required for differentiation of Th17 cells that mediate both protective and pathogenic immunity. However, little is known about the fu…
View article: A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks
A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks Open
It is well established that the gene expression patterns are substantially altered in cardiac hypertrophy and heart failure, however, less is known about the reasons behind such global differences. MicroRNAs (miRNAs) are short non-coding R…
View article: Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment
Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment Open
The transcription factor retinoid acid–related orphan receptor γ t (RORγt) directs the differentiation of Th17 cells. Th17 cells mediate pathological immune responses responsible for autoimmune diseases, including psoriasis and multiple sc…
View article: A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.
A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. Open
This article has been withdrawn by the authors.Evaluation by the journal with image analysis software determined that in Fig. 5A, lanes 1-3 of the RB1 immunoblot were duplicated in lanes 4 -6, lane 4 of the ERBB2 immunoblot was duplicated …