Subham Guin
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View article: Inhibition of Mac-1 allows human macrophages to migrate against the direction of shear flow on ICAM-1
Inhibition of Mac-1 allows human macrophages to migrate against the direction of shear flow on ICAM-1 Open
All immune cells must transit from the blood to distal sites such as the lymph nodes, bone marrow, or sites of infection. Blood borne monocytes traffic to the site of inflammation by adhering to the endothelial surface and migrating along …
View article: Lipid Metabolism Modulatory Cisplatin Prodrug Sensitizes Resistant Prostate Cancer toward Androgen Deprivation Therapy
Lipid Metabolism Modulatory Cisplatin Prodrug Sensitizes Resistant Prostate Cancer toward Androgen Deprivation Therapy Open
Mainstream treatment modalities which dominate the therapeutic landscape of prostate cancer (PCa) are prostatectomy, radiation therapy, and androgen deprivation therapy (ADT) or castration. These therapeutic options can extend the life exp…
View article: Let's Get Rolling: Precise Control of Microfluidic Assay Conditions to Recapitulate Selectin‐Mediated Rolling Interactions of the Leukocyte Adhesion Cascade
Let's Get Rolling: Precise Control of Microfluidic Assay Conditions to Recapitulate Selectin‐Mediated Rolling Interactions of the Leukocyte Adhesion Cascade Open
The leukocyte adhesion cascade governs the recruitment of circulating immune cells from the vasculature to distal sites. The initial adhesive interactions between cell surface ligands displaying sialyl‐Lewis X (sLe X ) and endothelial E‐ a…
View article: Not all (cells) who wander are lost: Upstream migration as a pervasive mode of amoeboid cell motility
Not all (cells) who wander are lost: Upstream migration as a pervasive mode of amoeboid cell motility Open
Leukocytes possess the ability to migrate upstream—against the direction of flow—on surfaces of specific chemistry. Upstream migration was first characterized in vitro for T-cells on surfaces comprised of intracellular adhesion molecule-1 …
View article: Correction to “New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance”
Correction to “New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance” Open
[This corrects the article DOI: 10.1021/acscentsci.3c00286.].
View article: New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance
New Pathway for Cisplatin Prodrug to Utilize Metabolic Substrate Preference to Overcome Cancer Intrinsic Resistance Open
Tumor cells adapt to diverse survival strategies defying our pursuit of multimodal cancer therapy. Prostate cancer (PCa) is an example that is resistant to one of the most potent chemotherapeutics, cisplatin. PCa cells survive and prolifer…
View article: Blending of Designer Synthetic Polymers to a Dual Targeted Nanoformulation for SARS-CoV-2 Associated Kidney Damage
Blending of Designer Synthetic Polymers to a Dual Targeted Nanoformulation for SARS-CoV-2 Associated Kidney Damage Open
As the COVID-19 pandemic has continued to spread, studies have shown that hospitalized COVID-19 patients are at significant risk for developing acute kidney injury (AKI), which can cause increased morbidity, the need for dialysis treatment…