Subhamoy Pal
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View article: Dementia etiology classification using NULISA plasma biomarkers and machine learning
Dementia etiology classification using NULISA plasma biomarkers and machine learning Open
INTRODUCTION Accurate antemortem differentiation among dementia etiologies remains challenging, particularly for atypical or mixed clinical presentations. Multiplexed plasma proteomics paired with supervised machine-learning offers a minim…
Cardiometabolic disorders and mild cognitive impairment in White and Black Americans Open
INTRODUCTION Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia. We investigate associations among cardiovascular and metabolic disorders (hypertension, diabetes mellitus, and hyperlipidemia) …
Employee Perspectives on Genetic Testing in the Workplace: Results from a National Survey Open
Introduction: Genetic testing for health-related purposes is now offered in some workplace wellness programs, with notable ethical, legal, and social implications. However, little is known about employee perspectives on workplace genetic t…
Cannabis use and cognition in older adults: Preliminary performance-based neuropsychological test results and directions for future research Open
Objective: We evaluated performance-based differences in neuropsychological functioning in older adults (age 65+) across the dementia continuum (cognitively intact, mild cognitive impairment, and dementia) according to recent cannabis use …
View article: Occurrence of Metallo-β-Lactamase Among Gram-Negative Bacilli In A Tertiary Care Hospital and Their Antibiogram Patterns
Occurrence of Metallo-β-Lactamase Among Gram-Negative Bacilli In A Tertiary Care Hospital and Their Antibiogram Patterns Open
Metallo-beta-lactamases (MBLs) are enzymes that confer resistance to a broad spectrum of beta-lactam antibiotics, including carbapenems, which are often considered the last line of defense against multidrug-resistant bacterial infections. …
High rates of diagnostic discordance and co‐pathology: Insights into PSP from the NACC dataset Open
INTRODUCTION Clinical features associated with accurate clinico‐pathologic correlation within cognitive‐predominant progressive supranuclear palsy (PSP) presentations have not been extensively studied. We identified features affecting PSP …
Retest reliability and reliable change of community-dwelling Black/African American older adults with and without mild cognitive impairment using NIH Toolbox-Cognition Battery and Cogstate Brief Battery for laptop Open
Objective: With the increased use of computer-based tests in clinical and research settings, assessing retest reliability and reliable change of NIH Toolbox-Cognition Battery (NIHTB-CB) and Cogstate Brief Battery (Cogstate) is essential. P…
Evaluating the factor structure and construct validity of the NIH toolbox in older adults, with a focus on cognitive normalcy and amnestic mild cognitive impairment: considerations for diversity, including insights from persons over 85 years of age and Black older Americans Open
Objective: Validated computerized assessments for cognitive functioning are crucial for older individuals and those at risk of cognitive decline. The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB-CB) exhibits good co…
View article: The impact of knowledge of β‐amyloid PET scan result on cognitive test performance: results of the REVEAL‐SCAN study
The impact of knowledge of β‐amyloid PET scan result on cognitive test performance: results of the REVEAL‐SCAN study Open
Background The impact of knowledge of β‐amyloid status on cognitively unimpaired persons' cognitive test performance is unknown. Method Cognitively unimpaired adults aged 65‐80 with a first‐degree relative with AD received a dementia risk …
Sleep Apnea in Arthritis Patients: A Multifactorial Analysis in the National Alzheimer’s Coordinating Center Cohort Open
Background Sleep apnea, a common sleep disorder, has been associated with various health conditions, including arthritis. This study investigates the relationship between sleep apnea and arthritis, examining how demographic and clinical ch…
Emory Wisconsin Card Sorting Test and Trail Making Test B as Measures of Executive Dysfunction Open
Background Wisconsin Card Sorting Test (WCST) and Trail Making Test‐Part B (Trails B) are commonly used neuropsychological measures of executive functioning. Previously, Trails B was found to be more sensitive than the WCST in predicting e…
The Genetic Information Nondiscrimination Act and workplace genetic testing: Knowledge and perceptions of employed adults in the United States Open
Workplace wellness programs are an emerging avenue for health‐related genetic testing, with some large employers now offering such testing to employees. Employees' knowledge and concerns regarding genetic discrimination may impact their de…
P864: Employees’ views and healthcare utilization following employer-sponsored pharmacogenomic testing at a large US healthcare system Open
While preemptive pharmacogenomic testing (PGx) has typically been constrained to specialized healthcare programs and consumer testing, voluntary workplace wellness programs that offer genetic testing (wGT) are expanding these opportunities…
PREVALENCE OF METABOLIC COMORBIDITIES AMONG COGNITIVELY NORMAL AND IMPAIRED WHITE AND AFRICAN AMERICANS Open
Assessing comorbidities associated with a MCI diagnosis is crucial for diagnostic accuracy and for understanding the role of comorbidities in cognitive decline. In this study of amnestic (aMCI) and non-amnestic (naMCI) MCI participants and…
Measurement Invariance of the NIH Toolbox‐Cognition Battery Across Demographic Characteristics Open
Background The tablet‐based NIH Toolbox‐Cognition Battery (NIHTB‐CB) was compared against the established NACC Uniform Data Set 3.0 (UDS 3.0) neuropsychological battery (used across Alzheimer’s Disease Research Centers). NIHTB‐CB factor in…
Comparing Clinical Diagnosis of Domains of Impairment in individuals with Mild Cognitive Impairment with the NIH Toolbox‐Cognitive Battery Performance Open
Background Mild Cognitive Impairment (MCI) represents the phase between age‐associated cognitive decline and Alzheimer’s disease and related dementias. Examination of these individuals may be especially important through computer‐based bat…
Role of mucin 2 gene for growth in Anas platyrhynchos: a novel report Open
Introduction The mucin gene is expressed in the mucous membrane of the inner layer of the internal organs. Intestinalmucin 2 (MUC2), amajor gel-formingmucin, represents a primary barrier component of mucus layers. Materials and methods Thi…
Etiologies of Acute Undifferentiated Febrile Illnesses in and near Iquitos from 1993 to 1999 in the Amazon River Basin of Peru Open
The objective of this study was to determine the etiology of febrile illnesses among patients from October 1, 1993 through September 30, 1999, in the urban community of Iquitos in the Amazon River Basin of Peru. Epidemiological and clinica…
Fully Human Immunoglobulin G From Transchromosomic Bovines Treats Nonhuman Primates Infected With Ebola Virus Makona Isolate Open
Transchromosomic bovines (Tc-bovines) adaptively produce fully human polyclonal immunoglobulin (Ig)G antibodies after exposure to immunogenic antigen(s). The National Interagency Confederation for Biological Research and collaborators rapi…
Assessing the Dengue Diagnosis Capability Gap in the Military Health System Open
Dengue, one of the most widespread infectious diseases, has affected U.S. military readiness throughout history. We explored the dengue diagnosis capability gap by circulating a questionnaire among military end users to determine in what c…