Subhash Mohan Agarwal
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View article: Microbiota antigen-specific regulatory T cells in colitis prevention and treatment 3977
Microbiota antigen-specific regulatory T cells in colitis prevention and treatment 3977 Open
Description The etiology of Inflammatory Bowel Disease is a dysregulated immune response to the intestinal microbiota in genetically predisposed individuals. At homeostasis, there is balance of regulatory T (Treg) cells and CD4+ effector T…
View article: Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data
Safety, pharmacokinetics, and pharmacodynamics of MK-6194, an IL-2 mutein designed to selectively activate regulatory T cells: single ascending dose and multiple ascending dose trial data Open
MK-6194, an interleukin-2 mutein designed to selectively activate regulatory T cells (Tregs), was evaluated for safety, pharmacokinetics (PK), immunogenicity, and pharmacodynamics in healthy participants. In a single ascending dose trial (…
View article: Efficacy and Safety of Altibrain® as an Adjunctive Therapy for Autism Spectrum Disorder: An Open Label Trial Targeting Core Symptoms
Efficacy and Safety of Altibrain® as an Adjunctive Therapy for Autism Spectrum Disorder: An Open Label Trial Targeting Core Symptoms Open
Objective: This study aimed to evaluate the effectiveness and safety of Altibrain® in combination with standard Autism Spectrum Disorder (ASD) treatment compared to standard ASD treatment alone in individuals diagnosed with ASD. Methods: A…
View article: PhyIndBC: Development of a machine learning tool for screening of potential breast cancer inhibitors from phytochemicals
PhyIndBC: Development of a machine learning tool for screening of potential breast cancer inhibitors from phytochemicals Open
Breast cancer is the foremost contributor to cancer-related mortality among women on a global scale. However, its treatment encounters challenges compounded by the disease's complexity. A promising avenue in the quest for effective therape…
View article: Machine Learning, Molecular Docking, and Dynamics-Based Computational Identification of Potential Inhibitors against Lung Cancer
Machine Learning, Molecular Docking, and Dynamics-Based Computational Identification of Potential Inhibitors against Lung Cancer Open
[Image: see text] Lung cancer is the most prevalent cause of cancer deaths worldwide. However, its treatment faces a significant hurdle due to the development of resistance. Phytomolecules are an important source of new chemical entities d…
View article: Genome sequencing of SARS-CoV-2 omicron variants in Delhi reveals alterations in immunogenic regions in spike glycoprotein
Genome sequencing of SARS-CoV-2 omicron variants in Delhi reveals alterations in immunogenic regions in spike glycoprotein Open
The SARS-CoV-2 omicron variants keep accumulating a large number of mutations in the spike (S) protein, which contributes to greater transmissibility and a rapid rise to dominance within populations. The identification of mutations and the…
View article: A systematic pipeline of protein structure selection for computer‐aided drug discovery: A case study on <scp>T790M/L858R</scp> mutant <scp>EGFR</scp> structures
A systematic pipeline of protein structure selection for computer‐aided drug discovery: A case study on <span>T790M/L858R</span> mutant <span>EGFR</span> structures Open
Virtual screening (VS) is a routine method to evaluate chemical libraries for lead identification. Therefore, the selection of appropriate protein structures for VS is an essential prerequisite to identify true actives during docking. But …
View article: Meta-Analysis of 49 SNPs Covering 25,446 Cases and 41,106 Controls Identifies Polymorphisms in Hormone Regulation and DNA Repair Genes Associated with Increased Endometrial Cancer Risk
Meta-Analysis of 49 SNPs Covering 25,446 Cases and 41,106 Controls Identifies Polymorphisms in Hormone Regulation and DNA Repair Genes Associated with Increased Endometrial Cancer Risk Open
Endometrial cancer (EC) is among the most common gynecological disorders globally. As single nucleotide polymorphisms (SNPs) play an important role in the causation of EC, therefore, a comprehensive meta-analysis of 49 SNPs covering 25,446…
View article: Recent advances in the area of plant-based anti-cancer drug discovery using computational approaches
Recent advances in the area of plant-based anti-cancer drug discovery using computational approaches Open
View article: A comprehensive meta-analysis of non-coding polymorphisms associated with precancerous lesions and cervical cancer
A comprehensive meta-analysis of non-coding polymorphisms associated with precancerous lesions and cervical cancer Open
We identified potential non-coding SNPs corresponding to various cytokines like interleukins (ILs), tumor necrosis factor (TNF), interferon (IFN) and other immune related genes like toll like receptor (TLR), cytotoxic T-lymphocyte associat…
View article: Computational identification of natural product inhibitors against EGFR double mutant (T790M/L858R) by integrating ADMET, machine learning, molecular docking and a dynamics approach
Computational identification of natural product inhibitors against EGFR double mutant (T790M/L858R) by integrating ADMET, machine learning, molecular docking and a dynamics approach Open
Identification of ADMET adherent natural products that have high affinity for double mutated drug-resistant EGFR.
View article: Exploring structural features of EGFR–HER2 dual inhibitors as anti-cancer agents using G-QSAR approach
Exploring structural features of EGFR–HER2 dual inhibitors as anti-cancer agents using G-QSAR approach Open
Simultaneous inhibition of EGFR and HER2 by dual-targeting inhibitors is an established anti-cancer strategy. Therefore, a recent trend in drug discovery involves understanding the features of such dual inhibitors. In this study, three dif…
View article: Practical consensus recommendations regarding the management of hormone receptor positive early breast cancer in elderly women
Practical consensus recommendations regarding the management of hormone receptor positive early breast cancer in elderly women Open
Breast cancer is a leading cause of death among women, and its incidence increases with age. Currently the treatment of breast cancer in older patients is almost identical to their younger counterparts. This expert group used data from pub…
View article: Unraveling structural requirements of amino-pyrimidine T790M/L858R double mutant EGFR inhibitors: 2D and 3D QSAR study
Unraveling structural requirements of amino-pyrimidine T790M/L858R double mutant EGFR inhibitors: 2D and 3D QSAR study Open
EGFR is an important drug target in cancer. However, the ineffectiveness of first generation inhibitors due to the occurrence of a secondary mutation (T790M) results in the relapse of the disease. Identification of reversible inhibitors ag…
View article: CCDC 1410921: Experimental Crystal Structure Determination
CCDC 1410921: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1410920: Experimental Crystal Structure Determination
CCDC 1410920: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Meta-Analysis of Standard Versus Hypofractionated Whole-Breast Radiation Therapy as Part of Breast Conserving Therapy for Early-Stage Breast Cancer
Meta-Analysis of Standard Versus Hypofractionated Whole-Breast Radiation Therapy as Part of Breast Conserving Therapy for Early-Stage Breast Cancer Open
View article: Fluctuations in network dynamics: SMAR1 can trigger apoptosis
Fluctuations in network dynamics: SMAR1 can trigger apoptosis Open
SMAR1 is a sensitive signaling molecule in p53 regulatory network which can drive p53 network dynamics to three distinct states, namely, stabilized (two), damped and sustain oscillation states. In the interaction of p53 network with SMAR1,…
View article: QSAR based model for discriminating EGFR inhibitors and non-inhibitors using Random forest
QSAR based model for discriminating EGFR inhibitors and non-inhibitors using Random forest Open
View article: CCDC 1036519: Experimental Crystal Structure Determination
CCDC 1036519: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1007369: Experimental Crystal Structure Determination
CCDC 1007369: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1007370: Experimental Crystal Structure Determination
CCDC 1007370: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1007368: Experimental Crystal Structure Determination
CCDC 1007368: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …