Explanipedia

Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections Open

Subhashini A. Sellers, Jens Schreiber, Mark T. Heise · 2025

IntroductionInfluenza infections result in a wide spectrum of disease outcomes, ranging from asymptomatic cases to fatal illness. While immunopathology contributes to an increased risk of hospitalization, the host factors that drive predis…

Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections Open

Klaus Schughart, Subhashini A. Sellers, W.A. Fischer, Jens Schreiber, Eva Lücke · 2025

Introduction Influenza infections result in a wide spectrum of disease outcomes, ranging from asymptomatic cases to fatal illness. While immunopathology contributes to an increased risk of hospitalization, the host factors that drive predi…

Highly dampened blood transcriptome response in HIV patients after respiratory infection Open

Subhashini A. Sellers, William A. Fischer, Mark T. Heise, Klaus Schughart · 2025

Author Correction: Highly dampened blood transcriptome response in HIV patients after respiratory infection Open

Subhashini A. Sellers, William A. Fischer, Mark T. Heise, Klaus Schughart · 2025

SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study Open

Emily J. Ciccone, Paul N. Zivich, Evans K. Lodge, Deanna Zhu, Elle Law , et al. · 2025

BACKGROUND: Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversi…

Longitudinal SARS-CoV-2 Testing among the Unvaccinated Is Punctuated by Intermittent Positivity and Variable Rates of Increasing Cycle Threshold Values Open

Shawn E. Hawken, Subhashini A. Sellers, Jason R. Smedberg, Jeremy D. Ward, Avian Elliott , et al. · 2025

The coronavirus disease 2019 (COVID-19) pandemic is complicated by cases of vaccine breakthrough and reinfection and widespread transmission of variants of concern (VOCs). Consequently, the need to interpret longitudinal positive severe ac…

Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open

Sean P. Collins, Matthew S. Shotwell, Jeffrey R. Strich, Kevin W. Gibbs, Marjolein de Wit , et al. · 2024

Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. This multicenter, phase 3, placebo…

Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open

Sean P. Collins, Matthew S. Shotwell, Jeffrey R. Strich, Kevin W. Gibbs, Marjolein de Wit , et al. · 2024

Importance Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. Objective To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. Design, Setti…

Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response Open

Klaus Schughart, Amber M. Smith, Ephraim L. Tsalik, Stephen C. Threlkeld, Subhashini A. Sellers , et al. · 2024

Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily driven by immunopa…

Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response Open

Klaus Schughart, Amber M. Smith, Ephraim L. Tsalik, Stephen C. Threlkeld, Subhashini A. Sellers , et al. · 2024

Introduction Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily drive…

Optimal Lung Cancer Screening Criteria Among Persons Living With HIV Open

Subhashini A. Sellers, Andrew Edmonds, Catalina Ramirez, Sushma K. Cribbs, I. Ofotokun , et al. · 2023

Background:The US Preventive Services Task Force (USPSTF) 2021 updated recommendations on lung cancer screening with chest computed tomography to apply to individuals 50-80 years of age (previously 55-80 years), with a ≥20 pack-year histor…

Longitudinal SARS-CoV-2 Testing among the Unvaccinated Is Punctuated by Intermittent Positivity and Variable Rates of Increasing Cycle Threshold Values Open

Shawn E. Hawken, Subhashini A. Sellers, Jason R. Smedberg, Jeremy D. Ward, Avian Elliott , et al. · 2022

We describe the duration of positivity and the COVID-19 treatment and outcome characteristics of an unvaccinated population of patients with prolonged SARS-CoV-2 positivity. This investigation serves to highlight challenges in using C T va…

Longitudinal SARS-CoV-2 testing is punctuated by intermittent positivity and variable rates of cycle-threshold decline Open

Shawn E. Hawken, Subhashini A. Sellers, Jason R. Smedberg, Jeremy D. Ward, Herbert C. Whinna , et al. · 2021

The COVID-19 pandemic is complicated by cases of vaccine-breakthrough, re-infection, and widespread transmission of variants of concern (VOC). Consequently, the need to interpret longitudinal positive SARS-CoV-2 (SCV-2) tests is crucial in…

Author Correction: Highly dampened blood transcriptome response in HIV patients after respiratory infection Open

Subhashini A. Sellers, William A. Fischer, Mark T. Heise, Klaus Schughart · 2021

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study Open

Emily J. Ciccone, Paul N. Zivich, Evans K. Lodge, Deanna Zhu, Elle Law , et al. · 2021

Background Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversio…

Highly dampened blood transcriptome response in HIV patients after respiratory infection Open

Subhashini A. Sellers, William A. Fischer, Mark T. Heise, Klaus Schughart · 2021

Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known abou…

<i>Pneumocystis</i> and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection: A Case Report and Review of an Emerging Diagnostic Dilemma Open

Carlos Rubiano, Kathleen Tompkins, Subhashini A. Sellers, Brian Bramson, Joseph J. Eron , et al. · 2020

We present a case of a critically ill patient with coronavirus disease 2019 (COVID-19) found to have acquired immune deficiency syndrome and Pneumocystis jirovecii pneumonia (PCP). Coronavirus disease 2019 and PCP co-occurrence is increasi…

SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study (Preprint) Open

Emily J. Ciccone, Paul N. Zivich, Evans K. Lodge, Deanna Zhu, Elle Law , et al. · 2020

BACKGROUND Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversi…

Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels Open

Carolina Caro‐Vegas, Subhashini A. Sellers, Kurtis M. Host, Jedidiah Seltzer, Justin T. Landis , et al. · 2020

KSHV-associated inflammatory cytokine syndrome (KICS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). KICS is associated with high-level, systemic replication of KSHV. This study characterized the clinical and virologic featur…

Age-associated changes in the respiratory epithelial response to influenza infection Open

Kelly D. Chason, Ilona Jaspers, Joel S. Parker, Subhashini A. Sellers, Louisa Brighton , et al. · 2020

Older adults suffer a disproportionate burden of influenza-related morbidity and mortality typically attributed to defects in the aging immune system collectively known as immunosenescence. While the age-related decline in the adaptive imm…

Burden of respiratory viral infection in persons with human immunodeficiency virus Open

Subhashini A. Sellers, Kenton Dover, Aubrey Bailey, Avery Cheves, Anthony B. Eason , et al. · 2020

This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real-time reverse transcription polymerase chain reaction and primer-in…

The hidden burden of influenza: A review of the extra-pulmonary complications of influenza infection Open

Subhashini A. Sellers, Robert S. Hagan, Frederick G. Hayden, William A. Fischer · 2020

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest tha…

Burden of respiratory viral infection in persons with human immunodeficiency virus Open

Subhashini A. Sellers, Kenton Dover, Aubrey Bailey, Avery Cheves, Anthony B. Eason , et al. · 2020

This study was conducted to determine the prevalence of respiratory viral infections (RVI) in persons living with HIV (PLH) admitted with a respiratory complaint using real‐time reverse transcription polymerase chain reaction and primer‐in…

Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels Open

Carolina Caro‐Vegas, Subhashini A. Sellers, Kurtis M. Host, Jedediah Seltzer, Justin T. Landis , et al. · 2019

349. Implementation of a Multidisciplinary HIV-Pulmonary Clinic Open

Subhashini A. Sellers, Amy L. Durr, Aarti Sanghani, Jonah K. Pierce, Hannah D Little , et al. · 2019

Background Among people with HIV (PWH), pulmonary comorbiditiees are a leading cause of morbidity and mortality. As PWH live a near-normal lifespan with ART, the focus has shifted from opportunistic infections to chronic disease. This incl…

2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients Open

Subhashini A. Sellers, Kenton Dover, David A. Wohl, Melissa B. Miller, Dirk P. Dittmer , et al. · 2018

BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung dis…

630. Identification of a Depressed Mucosal Immune Environment in HIV Infection Open

Subhashini A. Sellers, Kelly D. Chason, William A. Fischer · 2018

BACKGROUND: Among patients with human immunodeficiency virus (HIV), pulmonary complications are a common cause of morbidity and mortality. Emerging evidence suggests that respiratory viruses contribute to this disease burden. Although HIV …

Age-Associated Changes in the Respiratory Epithelial Response to Influenza Infection Open

Kelly D. Chason, Ilona Jaspers, Joel S. Parker, Subhashini A. Sellers, Louisa Brighton , et al. · 2018

Older adults suffer a disproportionate burden of influenza-related morbidity and mortality typically attributed to defects in the aging immune system collectively known as immunosenescence. While the age-related decline in the adaptive imm…

The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection Open

Subhashini A. Sellers, Robert S. Hagan, Frederick G. Hayden, William A. Fischer · 2017

Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest tha…

Respiratory Mucosal Immune Suppression in HIV-infected Individuals Open

Subhashini A. Sellers, Kelly D. Chason, William A. Fischer · 2017

Among patients with human immunodeficiency virus (HIV), pulmonary complications are a common cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described, respiratory viruses remain poorly understood. Eviden…

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