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View article: Molecular Mechanisms of Castration Resistance and the Current Clinical Landscape of CRPC Treatment
Molecular Mechanisms of Castration Resistance and the Current Clinical Landscape of CRPC Treatment Open
Castrate-resistant prostate cancer (CRPC) is characterized by the persistence and progression of the disease in spite of androgen deprivation treatment (ADT), the standard practice for initial treatment for advanced or metastatic prostate …
View article: From lab to life: technological innovations in transforming cancer metastasis detection and therapy
From lab to life: technological innovations in transforming cancer metastasis detection and therapy Open
Cancer metastasis remains the leading cause of cancer-related mortality and represents a major therapeutic bottleneck, primarily due to the limited availability of effective, targeted treatment strategies. While key oncogenic drivers such …
View article: Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 3: A, Violin plots showing the number of genes (top panel) and unique molecular identifier (UMI) (bottom panel) of control and M-I-treated CD45+ cells. B, Number of the genes in each cluster is shown.
View article: Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 2: Image showing the gating strategy of flow cytometry and cell sorting.
View article: Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Head and neck cancer (HNC) is prevalent worldwide, and treatment options are limited. Momordicine-I (M-I), a natural component from bitter melon, shows antitumor activity against these cancers, but its mechanism of action, especially in th…
View article: Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 2 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 2: Image showing the gating strategy of flow cytometry and cell sorting.
View article: Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 1: MOC2 cells treated with bitter melon extract (BME) or momordicine -I (M-I). Cell number was enumerated by the Trypan blue dye exclusion method after 48 hours of treatment. The results shown are the average of three …
View article: Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 4: A, Volcano plot illustrates the expression of genes in cDC2 populations in the treated group as compared to the control tumors. The x-axis represents log2 -fold change, and the y-axis denotes (−log10) p-value showin…
View article: Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 4: A, Volcano plot illustrates the expression of genes in cDC2 populations in the treated group as compared to the control tumors. The x-axis represents log2 -fold change, and the y-axis denotes (−log10) p-value showin…
View article: Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Data from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Head and neck cancer (HNC) is prevalent worldwide, and treatment options are limited. Momordicine-I (M-I), a natural component from bitter melon, shows antitumor activity against these cancers, but its mechanism of action, especially in th…
View article: Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 3: A, Violin plots showing the number of genes (top panel) and unique molecular identifier (UMI) (bottom panel) of control and M-I-treated CD45+ cells. B, Number of the genes in each cluster is shown.
View article: Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Supplementary Figure 1: MOC2 cells treated with bitter melon extract (BME) or momordicine -I (M-I). Cell number was enumerated by the Trypan blue dye exclusion method after 48 hours of treatment. The results shown are the average of three …
View article: Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes Open
Head and neck cancer (HNC) is prevalent worldwide, and treatment options are limited. Momordicine-I (M-I), a natural component from bitter melon, shows antitumor activity against these cancers, but its mechanism of action, especially in th…
View article: Emerging Potential of Momordica’s Bioactive Phytochemicals in Cancer Prevention and Therapy
Emerging Potential of Momordica’s Bioactive Phytochemicals in Cancer Prevention and Therapy Open
Worldwide, cancer incidence and mortality are rising quickly. Cancer remains the biggest cause of death despite advances in therapy. Plants produce bioactive phytochemicals, and as a result, the bioactive elements have long been the focus …
View article: Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications
Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications Open
Oral cancer (OC) is among the most prevalent cancers in the world. Certain geographical areas are disproportionately affected by OC cases due to the regional differences in dietary habits, tobacco and alcohol consumption. However, conventi…
View article: Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial Cells
Circulatory Exosomes from COVID-19 Patients Trigger NLRP3 Inflammasome in Endothelial Cells Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global health problem. Although the vaccine controls infection, understanding the molecular mechanism of pathogenesis will help in developing future therapies.
View article: Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells
Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells Open
SARS-CoV-2 infection induces inflammatory response, cytokine storm, venous thromboembolism, coagulopathy, and multiple organ damage. Resting endothelial cells prevent coagulation, control blood flow and inhibit inflammation. However, it re…
View article: Emerging role of lncRNA ELDR in development and cancer
Emerging role of lncRNA ELDR in development and cancer Open
Whole‐genome sequencing and transcriptome analysis revealed more than 90% of the human genome transcribes noncoding RNAs including lncRNAs. From the beginning of the 21st century, lncRNAs have gained widespread attention as a new layer of …
View article: Momordicine-I, a Bitter Melon Bioactive Metabolite, Displays Anti-Tumor Activity in Head and Neck Cancer Involving c-Met and Downstream Signaling
Momordicine-I, a Bitter Melon Bioactive Metabolite, Displays Anti-Tumor Activity in Head and Neck Cancer Involving c-Met and Downstream Signaling Open
Head and neck cancer (HNC) is one of the most aggressive cancers, and treatments are quite challenging due to the difficulty in early diagnosis, lack of effective chemotherapeutic drugs, adverse side effects and therapy resistance. We iden…
View article: Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ
Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-β in Triggering Inflammatory Signals in Cells of Distant Organ Open
SARS-CoV-2 infection can cause cytokine storm and may overshoot immunity in humans; however, it remains to be determined whether virus-induced soluble mediators from infected cells are carried by exosomes as vehicles to distant organs and …
View article: Diverse roles of bitter melon (<i>Momordica charantia</i>) in prevention of oral cancer
Diverse roles of bitter melon (<i>Momordica charantia</i>) in prevention of oral cancer Open
Oral squamous cell carcinoma (OSCC) is one of the common lethal malignancies which is increasing rapidly in the world. Increasing risks from alcohol and tobacco habits, lack of early detection markers, lack of effective chemotherapeutic ag…
View article: Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in distant organ cells
Exosomes from COVID-19 patients carry tenascin-C and fibrinogen-β in triggering inflammatory signals in distant organ cells Open
SARS-CoV-2 infection causes cytokine storm and overshoot immunity in humans; however, it remains to be determined whether genetic material of SARS-CoV-2 and/or virus induced soluble mediators from lung epithelial cells as natural host are …
View article: Inhibition of Long Noncoding RNA Linc‐Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis
Inhibition of Long Noncoding RNA Linc‐Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis Open
Background and Aims HCV often causes chronic infection in liver, cirrhosis, and, in some instances, HCC. HCV encodes several factors' those impair host genes for establishment of chronic infection. The long noncoding RNAs (lncRNAs) display…
View article: Table of contents
Table of contents Open
Study Cover Figure: C-X-C motif chemokine ligand 1 (CXCL1)induced neutrophil infiltration and reactive oxygen species (ROS) production activates ROS-sensitive kinases and their downstream stress kinases (p38 and JNK) and subsequently enhan…
View article: Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy
Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy Open
Cancer is the second leading cause of death worldwide. Many dietary plant products show promising anticancer effects. Bitter melon or bitter gourd (Momordica charantia) is a nutrient-rich medicinal plant cultivated in tropical and subtropi…
View article: Establishment of a Patient‐Derived Xenograft Tumor From Hepatitis C–Associated Liver Cancer and Evaluation of Imatinib Treatment Efficacy
Establishment of a Patient‐Derived Xenograft Tumor From Hepatitis C–Associated Liver Cancer and Evaluation of Imatinib Treatment Efficacy Open
Background and Aims Chronic hepatitis C virus (HCV) infection is one of the major causal factors for hepatocellular carcinoma (HCC). The treatment options for HCC are limited for lack of a convenient animal model for study in HCV infection…
View article: Correction to: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract
Correction to: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract Open
Following publication of the original article [1], it was reported that Fig. 1c was not entirely readable due to overlapping Fig. 1d. The publishers apologise for this error.
View article: miRNA-29b Inhibits Prostate Tumor Growth and Induces Apoptosis by Increasing Bim Expression
miRNA-29b Inhibits Prostate Tumor Growth and Induces Apoptosis by Increasing Bim Expression Open
Prostate cancer is one of the most common cancers among men. Currently available therapies improve patient survival against local prostate cancer but have shown severe side effects. Advanced prostate cancer is still incurable. Studies have…