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View article: Scaffold-induced compression enhances ligamentization potential of decellularized tendon graft reseeded with ACL-derived cells
Scaffold-induced compression enhances ligamentization potential of decellularized tendon graft reseeded with ACL-derived cells Open
Anterior cruciate ligament (ACL) reconstruction is often performed using a tendon graft. However, the predominant synthesis of fibrotic scar tissue (type III collagen) occurs during the healing process of the tendon graft, resulting in a s…
View article: Extracellular <scp>PPM1A</scp> promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the <scp>FOXO1A‐RUNX2</scp> pathway
Extracellular <span>PPM1A</span> promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the <span>FOXO1A‐RUNX2</span> pathway Open
Protein phosphatase magnesium‐dependent 1A (PPM1A), serine/threonine protein phosphatase, in sera level was increased in patients with ankylosing spondylitis (AS). Preosteoblasts were differentiated actively to matured osteoblasts by intra…
View article: The TNF-NF-κB-DKK1 Axis Promoted Bone Formation in the Enthesis of Ankylosing Spondylitis
The TNF-NF-κB-DKK1 Axis Promoted Bone Formation in the Enthesis of Ankylosing Spondylitis Open
TNF induced DKK1 expression in the enthesis through NF-kB activation TNF-induced DKK1 expression may play a bone formation in the radiologic progression of ankylosing spondylitis.
View article: WNT16 Elevation Induced Cell Senescence of Osteoblasts in Ankylosing Spondylitis
WNT16 Elevation Induced Cell Senescence of Osteoblasts in Ankylosing Spondylitis Open
Background: WNT16 is critical for bone homeostasis, but the effect of WNT16 in ankylosing spondylitis (AS) is still unknown. Here, we investigated whether WNT16 influences bone formation and pathophysiological changes of AS in an in vitro …
View article: Blocking TNFα attenuates progressive cartilage matrix degradation in inflammatory arthritis
Blocking TNFα attenuates progressive cartilage matrix degradation in inflammatory arthritis Open
Because damage to hyaline cartilage is irreversible, relieving progressive cartilage destruction is an important therapeutic approach for inflammatory arthritis. In the present study, human hyaline chondrocytes were isolated from total kne…
View article: Effect of Muscle Cell Preservation on Viability and Differentiation of Hamstring Tendon Graft In Vitro
Effect of Muscle Cell Preservation on Viability and Differentiation of Hamstring Tendon Graft In Vitro Open
Muscle tissue is often removed during hamstring tendon graft preparation for anterior cruciate ligament (ACL) reconstruction. The purpose of the study was to test whether preservation of muscle remnants on a tendon graft is beneficial to t…
View article: TGFβ1 Suppressed Matrix Mineralization of Osteoblasts Differentiation by Regulating SMURF1–C/EBPβ–DKK1 Axis
TGFβ1 Suppressed Matrix Mineralization of Osteoblasts Differentiation by Regulating SMURF1–C/EBPβ–DKK1 Axis Open
Transforming growth factor β1 (TGFβ1) is a major mediator in the modulation of osteoblast differentiation. However, the underlying molecular mechanism is still not fully understood. Here, we show that TGFβ1 has a dual stage-dependent role …