Explanipedia

New opportunities for bioscaffold‐enabled spinal cord injury repair Open

Xiaoqing Qi, Yicheng Fu, Zhaoliang Su, Li Li, Subrata Chakrabarti , et al. · 2025

Spinal cord injury (SCI) leads to high rates of central nervous system impairment and imposes a significant treatment burden, highlighting the need for effective repair strategies. Bioscaffolds are considered to be multifunctional material…

Biopsy-Proven Solid Organ Transplant Graft-Versus-Host Disease (SOT-GVHD) Involving the Skin, Liver, and Bone Marrow in a Simultaneous Kidney-Pancreas Transplant Recipient Open

Reza Rahimi Shahmirzadi, Danielle Ouellette, Martin Igbokwe, Alp Şener, Manal Gabril , et al. · 2025

Background: Graft-versus-host disease (GVHD) is a rare but serious complication following solid organ transplantation (SOT), particularly in transplants involving organs with a high volume of passenger donor T-lymphocytes. This case highli…

Pancreas to Skin and Beyond: A Curious Case of Graft Versus Host Disease in a Kidney-Pancreas Transplant Open

Reza Rahimi Shahmirzadi, Danielle Ouellette, Martin Igbokwe, Alp Şener, Manal Gabril , et al. · 2025

A 51-year-old gentleman with complications from long-standing type 1 diabetes mellitus underwent simultaneous pancreas and pre-emptive kidney transplant at our center, with rabbit anti-thymocyte globulin and methylprednisolone induction. T…

Chemotherapy treatment alters DNA methylation patterns in the prefrontal cortex of female rat brain Open

Subrata Chakrabarti, Chanchal Wagh, Ciara Bagnall-Moreau, Fathema Uddin, John Reiser , et al. · 2025

Chemotherapy can cause several long-term side effects that can affect cancer survivors' quality of life-, notably cognitive decline in response to select chemotherapeutic agents. Studies using both human patients and animal models have bee…

A South Asian Indian PRKAG2 patient–derived induced pluripotent stem cell (iPSC) line to model glycogen storage-associated hypertrophic cardiomyopathy Open

Subrata Chakrabarti, Harshil Chittora, P. Jain, Hisham Ahamed, Perundurai S. Dhandapany · 2025

PRKAG2 is the ɣ2 regulatory subunit of the 5' AMP-activated protein kinase involved in cellular ATP metabolic regulation. Mutations in the PRKAG2 gene are known to cause glycogen storage-associated hypertrophic cardiomyopathy (HCM). We ide…

Use of serum long non-coding RNA expression panel as a marker for diabetic retinopathy Open

Eric Wang, Shali Chen, Arshad Ali, Biao Feng, Selina L. Liu , et al. · 2025

Introduction Diabetic retinopathy (DR) is the most common chronic complication of diabetes, the leading cause of vision impairments in working-aged adults, and a significant cause of reduced quality of life for diabetic patients. Diabetic …

Differential microvascular endothelial cell responses in the retina in diabetes compared to the heart and kidneys, a spatial transcriptomic analysis Open

Eric Wang, Biao Feng, Shali Chen, Zhaoliang Su, Subrata Chakrabarti · 2024

Endothelial cells and high glucose-induced endothelial dysfunction are the common origin of chronic diabetic complications such as retinopathy, nephropathy, and cardiomyopathy. Yet their common origins, the vascular manifestations of such …

Author Correction: Ascorbyl palmitate nanofiber-reinforced hydrogels for drug delivery in soft tissues Open

Yasmeen Shamiya, Aishik Chakraborty, Alap Ali Zahid, Nicholas Bainbridge, Jingyuan Guan , et al. · 2024

Ascorbyl palmitate nanofiber-reinforced hydrogels for drug delivery in soft tissues Open

Yasmeen Shamiya, Aishik Chakraborty, Alap Ali Zahid, Nicholas Bainbridge, Jingyuan Guan , et al. · 2024

Nanofiber-based hydrogel delivery systems have recently shown great potential in biomedical applications, specifically due to their high surface-to-volume ratio of ultra-fine nanofibers and their ability to carry low solubility drugs. Here…

CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy Open

Honglin Wang, Eric Wang, Biao Feng, Subrata Chakrabarti · 2024

Noncoding RNAs play a part in many chronic diseases and interact with each other to regulate gene expression. MicroRNA-9-5p (miR9) has been thought to be a potential inhibitor of diabetic cardiomyopathy. Here we examined the role of miR9 i…

Ascorbyl palmitate nanofiber-reinforced hydrogels for drug delivery in soft issues Open

Arghya Paul, Yasmeen Shamiiya, Aishik Chakraborty, Alap Ali Zahid, Nicholas Bainbridge , et al. · 2024

Nanofiber-based hydrogel delivery systems have recently shown great potential in biomedical applications, specifically due to their high surface-to-volume ratio of ultra-fine nanofibers, ability to carry low solubility drugs, and ability t…

CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy Open

Honglin Wang, Biao Feng, Eric Wang, Subrata Chakrabarti · 2024

Noncoding RNAs play a part in many chronic diseases and interact with each other to regulate gene expression. MicroRNA-9-5p (miR9) has been thought to be a potential inhibitor of diabetic cardiomyopathy. Here we examined the role of miR9 i…

Cardiac resident macrophages: Spatiotemporal distribution, development, physiological functions, and their translational potential on cardiac diseases Open

Jing Jin, Yurou Wang, Yueqin Liu, Subrata Chakrabarti, Zhaoliang Su · 2024

Metabolic Dysfunction-Associated Steatohepatitis Detected by Neutrophilic Crown-Like Structures in Morbidly Obese Patients: A Multicenter and Clinicopathological Study Open

Mengqi Fan, Erfei Song, Yuying Zhang, Pengfei Zhang, Bing Huang , et al. · 2024

Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), and closely associated with a high risk of liver-related morbidity and mortality. Although…

Non-coding RNA-mediated endothelial-to-mesenchymal transition in human diabetic cardiomyopathy, potential regulation by DNA methylation Open

Eric Wang, Shali Chen, Honglin Wang, T Chen, Subrata Chakrabarti · 2023

Aims Diabetic cardiomyopathy (DCM) is a major complication of diabetes and a risk factor for cardiovascular disease. Endothelial dysfunction is central to DCM, and endothelial-to-mesenchymal transition (EndMT) is a key form of endothelial …

Identification and multicentric validation of soluble CDCP1 as a robust serological biomarker for risk stratification of NASH in obese Chinese Open

Xi Jia, Erfei Song, Yan Liu, Jiarui Chen, Pei Wan , et al. · 2023

The definitive diagnosis of non-alcoholic steatohepatitis (NASH) currently relies on invasive and labor-intensive liver biopsy. Here, we identified soluble CUB domain-containing protein 1 (sCDCP1) as a top-ranked non-invasive biomarker for…

Engineering multifunctional adhesive hydrogel patches for biomedical applications Open

Aishik Chakraborty, Shana Alexander, Wei Luo, Narisse Al‐Salam, Mia Van Oirschot , et al. · 2023

Traditional patches, such as sticking plaster or acrylic adhesives used for over a hundred years, lack functionality. To address this issue of poor functionality, adhesive hydrogel patches have emerged as an efficient bioactive multifuncti…

MicroRNA 9 Is a Regulator of Endothelial to Mesenchymal Transition in Diabetic Retinopathy Open

Eric Wang, Biao Feng, Subrata Chakrabarti · 2023

We have shown that miR-9 is an important regulator of EndMT in DR, potentially making it a good target for RNA-based therapy in early DR.

Endothelial-to-mesenchymal transition: An underappreciated mediator of diabetic complications Open

Eric Wang, Honglin Wang, Subrata Chakrabarti · 2023

Diabetes and its complications represent a great burden on the global healthcare system. Diabetic complications are fundamentally diseases of the vasculature, with endothelial cells being the centerpiece of early hyperglycemia-induced chan…

Editorial: Advances in the research of diabetic retinopathy Open

Subrata Chakrabarti, Michele Lanza, Khalid Siddiqui · 2022

EDITORIAL article Front. Endocrinol., 25 October 2022Sec. Clinical Diabetes Volume 13 - 2022 | https://doi.org/10.3389/fendo.2022.1038056

Junctophilin-2 promotes cardiomyocyte survival by blocking MURF1-mediated Junctin ubiquitination and proteasome-dependentdegradation Open

Xiaoyun Ji, Yifan Huang, Rui Ni, Zheng Dong, Guo‐Chang Fan , et al. · 2022

Aims Junctophilin-2 is required for the development, maturation and integrity of the t-tubule system and the gating stability of RyR2 in cardiomyocytes. This study investigated whether and how junctophilin-2 maintained junctin, a scaffold …

Endothelial derived miRNA-9 mediated cardiac fibrosis in diabetes and its regulation by ZFAS1 Open

Biao Feng, Jieting Liu, Eric Wang, Zhaoliang Su, Subrata Chakrabarti · 2022

Diabetic cardiomyopathy (DCM) is one of the most prevalent causes of morbidity and mortality in diabetic patients. Hyperglycemia induces increased expression/deposition of extracellular matrix (ECM) proteins including fibronectin (FN) and …

Renewal of embryonic and neonatal-derived cardiac-resident macrophages in response to environmental cues abrogated their potential to promote cardiomyocyte proliferation via Jagged-1–Notch1 Open

Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, Chong Wang , et al. · 2022

Cardiac-resident macrophages (CRMs) play important roles in homeostasis, cardiac function, and remodeling. Although CRMs play critical roles in cardiac regeneration of neonatal mice, their roles are yet to be fully elucidated. Therefore, t…

ANRIL regulates multiple molecules of pathogenetic significance in diabetic nephropathy Open

Parisa Sooshtari, Biao Feng, Saumik Biswas, Michael A. Levy, Hanxin Lin , et al. · 2022

Background Hyperglycemia-induced transcriptional alterations lead to aberrant synthesis of a large number of pathogenetic molecules leading to functional and structural damage to multiple end organs including the kidneys. Diabetic nephropa…

Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy Open

Xiao-yun Ji, Dong Zheng, Rui Ni, Jinxi Wang, Jianqiang Shao , et al. · 2022

Cardiac Mast Cells: A Two-Head Regulator in Cardiac Homeostasis and Pathogenesis Following Injury Open

Jing Jin, Yuanyuan Jiang, Subrata Chakrabarti, Zhaoliang Su · 2022

Cardiac mast cells (CMCs) are multifarious immune cells with complex roles both in cardiac physiological and pathological conditions, especially in cardiac fibrosis. Little is known about the physiological importance of CMCs in cardiac hom…

Serum Thrombospondin-2 Levels Are Closely Associated With the Severity of Metabolic Syndrome and Metabolic Associated Fatty Liver Disease Open

Xuerui Wu, Cynthia Kwan Yui Cheung, Dewei Ye, Subrata Chakrabarti, Hema Mahajan , et al. · 2022

Context Metabolic associated fatty liver disease (MAFLD) is the hepatic manifestation of obesity-related metabolic syndrome (MetS). Noninvasive biomarkers for monitoring the progression and severity of these metabolic comorbidities are nee…

Expressions of Serum lncRNAs in Diabetic Retinopathy – A Potential Diagnostic Tool Open

Saumik Biswas, Ali Coyle, Shali Chen, Mišo Gostimir, John R. Gonder , et al. · 2022

With increasing incidence of diabetes worldwide, there is an ever-expanding number of patients with chronic diabetic complications such as diabetic retinopathy (DR), one of the leading causes of blindness in the working age population. Ear…

Circular RNA mediated gene regulation in chronic diabetic complications Open

Nikhil S. Patil, Biao Feng, Zhaoliang Su, Christina A. Castellani, Subrata Chakrabarti · 2021

Chronic diabetic complications affect multiple organs causing widespread organ damage. Although there are some commonalities, the phenotype of such changes show tissue specific variation. Given this, we examined whether differences in circ…

Engineering nanoparticle therapeutics for impaired wound healing in diabetes Open

Yasmeen Shamiya, Shruthi Polla Ravi, Ali Coyle, Subrata Chakrabarti, Arghya Paul · 2021

Diabetes mellitus is a chronic disease characterized by increased blood glucose levels, leading to damage of the nerves blood vessels, subsequently manifesting as organ failures, wounds, or ulcerations. Wounds in patients with diabetes are…

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