Subrata Sen
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View article: Chromosome 20q gene signature associated with colorectal cancer progression
Chromosome 20q gene signature associated with colorectal cancer progression Open
Amplification of human chromosome 20q has been reported as the most frequently recurring genetic abnormality associated with large scale changes in mRNA and protein levels in sporadic colorectal carcinomas. While some studies have found 20…
View article: An integrated multi‐omics biomarker approach using molecular profiling and microRNAs for evaluation of pancreatic cyst fluid
An integrated multi‐omics biomarker approach using molecular profiling and microRNAs for evaluation of pancreatic cyst fluid Open
Background Classification and risk stratification of pancreatic cysts are challenging because of limited radiographic and cytomorphologic features. Although molecular profiling has emerged as an ancillary test for pancreatic cyst fluid (PC…
View article: 96 Spatial analysis reveals differential immune cell interactions in histologic progression areas of intraductal papillary mucinous neoplasms of the pancreas
96 Spatial analysis reveals differential immune cell interactions in histologic progression areas of intraductal papillary mucinous neoplasms of the pancreas Open
View article: Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer Open
View article: eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer Open
The translation elongation factor eEF1A promotes protein synthesis. Its methylation by METTL13 increases its activity, supporting tumor growth. However, in some cancers, a high abundance of eEF1A isoforms is associated with a good prognosi…
View article: Blood-Based microRNA Biomarker Signature of Early-Stage Pancreatic Ductal Adenocarcinoma With Lead-Time Trajectory in Prediagnostic Samples
Blood-Based microRNA Biomarker Signature of Early-Stage Pancreatic Ductal Adenocarcinoma With Lead-Time Trajectory in Prediagnostic Samples Open
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 48/2023
Graphisches Inhaltsverzeichnis: Angew. Chem. 48/2023 Open
…and materials does not always involve creating bonds.Intheir Research Article (e202310354), Jorge Albalad, Inhar Imaz, Daniel Maspoch et al. show how bond scission becomes ap owerful synthetic tool to design new molecules and materials wh…
View article: Supplementary Figure 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Figure 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Comparison of SNVs, CNAs and neoepitopes in LG and HG IPMNs
View article: FIGURE 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
FIGURE 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Inferred evolutionary trajectory derived from CNAs. Cases showing linear (A) and branched (B) evolution are depicted. For each case, evolutionary tree and segmentation plots are shown with HapLOHseq calls represented in laven…
View article: FIGURE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
FIGURE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Genomic landscapes of IPMN lesions. A, SNVs identified in KRAS and GNAS in LG and HG IPMNs. Dark purple: somatic mutations detected for KRAS and GNAS. Light purple: mutations detected by retesting. B,<…
View article: Data from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Data from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Intraductal papillary mucinous neoplasms (IPMN) are cystic precursor lesions to pancreatic ductal adenocarcinoma (PDAC). IPMNs undergo multistep progression from low-grade (LG) to high-grade (HG) dysplasia, culminating in invasive neoplasi…
View article: Supplementary Table 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Table 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
List of compartments dissected by LCM
View article: Supplementary Figure 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Figure 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Schematic representation of the strategy employed
View article: Supplementary Table 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Table 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Comparison in MAF and sequencing depth between a targeted and WES approach.
View article: Supplementary Table 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Table 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Correlation between PDAC molecular suptypes and 1q amplification in TCGA data
View article: Supplementary Figure 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Figure 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Schematic representation of the strategy employed
View article: FIGURE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
FIGURE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Genomic landscapes of IPMN lesions. A, SNVs identified in KRAS and GNAS in LG and HG IPMNs. Dark purple: somatic mutations detected for KRAS and GNAS. Light purple: mutations detected by retesting. B,<…
View article: Supplementary Table 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Table 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Correlation between PDAC molecular suptypes and 1q amplification in TCGA data
View article: FIGURE 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
FIGURE 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Comparison of CNAs between LG and HG IPMNs. A, AS between LG and HG by paired analysis, green lines show an increase of AS upon progression while red lines a decrease. Validation (B) and quantification (C) of chromosom…
View article: Supplementary Table 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Table 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Comparison in MAF and sequencing depth between a targeted and WES approach.
View article: FIGURE 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
FIGURE 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Comparison of CNAs between LG and HG IPMNs. A, AS between LG and HG by paired analysis, green lines show an increase of AS upon progression while red lines a decrease. Validation (B) and quantification (C) of chromosom…
View article: TABLE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
TABLE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Patient demographics and clinicopathologic characteristics
View article: Supplementary Table 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Table 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
List of compartments dissected by LCM
View article: Supplementary Figure 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Figure 2 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Comparison of SNVs, CNAs and neoepitopes in LG and HG IPMNs
View article: FIGURE 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
FIGURE 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Inferred evolutionary trajectory derived from CNAs. Cases showing linear (A) and branched (B) evolution are depicted. For each case, evolutionary tree and segmentation plots are shown with HapLOHseq calls represented in laven…
View article: Data from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Data from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Intraductal papillary mucinous neoplasms (IPMN) are cystic precursor lesions to pancreatic ductal adenocarcinoma (PDAC). IPMNs undergo multistep progression from low-grade (LG) to high-grade (HG) dysplasia, culminating in invasive neoplasi…
View article: Supplementary Figure 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Figure 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Evolutionary trajectory of IMPN lesions
View article: TABLE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
TABLE 1 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Patient demographics and clinicopathologic characteristics
View article: Supplementary Figure 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project
Supplementary Figure 3 from Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project Open
Evolutionary trajectory of IMPN lesions
View article: Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment
Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment Open
Pancreatic ductal adenocarcinoma (PDAC) cells display extensive crosstalk with their surrounding environment to regulate tumor growth, immune evasion, and metastasis. Recent advances have attributed many of these interactions to intercellu…