Suchi Chang
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View article: Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway
Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway Open
Lipopolysaccharide (LPS)-induced septic acute kidney injury (AKI) is determined as a devastating organ dysfunction elicited by an inappropriate response to infection with high morbidity and mortality rates. Previous evidence has illustrate…
View article: Association between sleep duration and quality with rapid kidney function decline and development of chronic kidney diseases in adults with normal kidney function: The China health and retirement longitudinal study
Association between sleep duration and quality with rapid kidney function decline and development of chronic kidney diseases in adults with normal kidney function: The China health and retirement longitudinal study Open
Research have shown that sleep is associated with renal function. However, the potential effects of sleep duration or quality on kidney function in middle-aged and older Chinese adults with normal kidney function has rarely been studied. O…
View article: Aldehyde Dehydrogenase 2 (ALDH2) Elicits Protection against Pulmonary Hypertension via Inhibition of ERK1/2‐Mediated Autophagy
Aldehyde Dehydrogenase 2 (ALDH2) Elicits Protection against Pulmonary Hypertension via Inhibition of ERK1/2‐Mediated Autophagy Open
Pulmonary hypertension (PH) is caused by chronic hypoxia that induces the migration and proliferation of pulmonary arterial smooth muscle cells (PASMCs), eventually resulting in right heart failure. PH has been related to aberrant autophag…
View article: SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching
SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose‐derived mesenchymal stem cells via metabolic switching Open
Background Mesenchymal stem cells (MSCs) have therapeutic potential for multiple ischemic diseases. However, in vitro expansion of MSCs before clinical application leads to metabolic reprogramming from glycolysis to oxidative phosphorylati…
View article: Neutrophil‐derived advanced glycation end products‐Nε‐(carboxymethyl) lysine promotes RIP3‐mediated myocardial necroptosis via RAGE and exacerbates myocardial ischemia/reperfusion injury
Neutrophil‐derived advanced glycation end products‐Nε‐(carboxymethyl) lysine promotes RIP3‐mediated myocardial necroptosis via RAGE and exacerbates myocardial ischemia/reperfusion injury Open
Nε‐(carboxymethyl) lysine (CML), the major member of advanced glycation end products, was widely studied in diabetic complications and aging‐associated diseases. However, the impact of CML on myocardial ischemia/reperfusion injury (MI/RI) …
View article: Predictors of mid-term prognosis and adverse factors in acute pulmonary embolism
Predictors of mid-term prognosis and adverse factors in acute pulmonary embolism Open
Background: To explore the differences in short and middle term adverse factors of pulmonary embolism (PE) outcome. Methods: This was a single-center retrospective study of inpatients admitted from Zhongshan Hospital, Fudan University, wit…