Suchitha Satish
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View article: EBV-triggered secondary macrophage activation syndrome in the backdrop of lupus in an adult
EBV-triggered secondary macrophage activation syndrome in the backdrop of lupus in an adult Open
Macrophage activating syndrome (MAS) is a potentially life-threatening condition falling under the spectrum of secondary hemophagocytic lymphohistiocytosis, in the backdrop of rheumatological conditions. In this case of a middle-aged man, …
View article: Histopathologic Emphasis on Subarachnoid Web Diagnosed on Neuroimaging
Histopathologic Emphasis on Subarachnoid Web Diagnosed on Neuroimaging Open
Department of Medicine, JSS Medical College, Mysore, Karnataka, India 1Department of Medicine, Vardhaman Mahavir Medical College and Safdarjang Hospital, New Delhi, India 2Department of Neurosurgery, JSS Medical College, Mysore, Karnataka,…
View article: Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways
Green Jackfruit Flour Prevents Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma via the AMPK and MAPK Signaling Pathways Open
Metabolic dysfunction-associated steatotic liver disease (MASLD), encompassing metabolic-dysfunction associated steatotic liver (MAFL) and steatohepatitis (MASH), which further progresses to hepatocellular carcinoma (HCC), is a serious pub…
View article: <scp>TACE</scp> inhibition: a promising therapeutic intervention against <scp>AATF</scp>‐mediated steatohepatitis to hepatocarcinogenesis
<span>TACE</span> inhibition: a promising therapeutic intervention against <span>AATF</span>‐mediated steatohepatitis to hepatocarcinogenesis Open
Metabolic dysfunction‐associated steatohepatitis‐driven hepatocellular carcinoma (MASH‐HCC) is a global clinical challenge for which there is a limited understanding of disease pathogenesis and a subsequent lack of therapeutic intervention…
View article: Clinicopathological Assessment of Modified Activity and Chronicity Indices in Lupus Nephritis at a Teaching Hospital in Mysore, India
Clinicopathological Assessment of Modified Activity and Chronicity Indices in Lupus Nephritis at a Teaching Hospital in Mysore, India Open
Introduction: In 20-49% of patients with Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN) is a major complication and, therefore, an important prognostic determinant of SLE. The Activity and Chronicity Indices (AI and CI), used as …
View article: Renal resistive index as a marker of histopathological damage in diabetic and non-diabetic chronic kidney disease
Renal resistive index as a marker of histopathological damage in diabetic and non-diabetic chronic kidney disease Open
Background Chronic kidney disease is a worldwide public health problem with diabetes being the leading cause. Renal resistive index derived by Duplex Doppler sonography, has been in use clinically to examine intrarenal hemodynamic abnormal…
View article: AATF inhibition exerts antiangiogenic effects against human hepatocellular carcinoma
AATF inhibition exerts antiangiogenic effects against human hepatocellular carcinoma Open
Background and aims Angiogenesis is a key factor in the growth and metastasis of hepatic tumors and thus a potential therapeutic target in hepatocellular carcinoma (HCC). In this study, we aim to identify the key role of apoptosis antagoni…
View article: Unraveling the Potential Role of Tecomella undulata in Experimental NASH
Unraveling the Potential Role of Tecomella undulata in Experimental NASH Open
The pathophysiology of nonalcoholic steatohepatitis (NASH) is complex, owing to its diverse pathological drivers and, until recently, there were no approved drugs for this disease. Tecomella is a popular herbal medicine used to treat hepat…
View article: Bacillary Angiomatosis of Lymph Nodes: Unusual Case Presentation in an Immunocompetent Adolescent
Bacillary Angiomatosis of Lymph Nodes: Unusual Case Presentation in an Immunocompetent Adolescent Open
Bacillary angiomatosis is a neovascular proliferative condition caused by the Bartonella group of opportunistic bacteria, commonly occurring in patients with advanced Human Immunodeficiency Virus (HIV) and other immunocompromised condition…
View article: Glomerular parietal epithelial expression of CD44 in minimal change nephrotic syndrome and primary focal segmental glomerulosclerosis: A clinico-pathological study
Glomerular parietal epithelial expression of CD44 in minimal change nephrotic syndrome and primary focal segmental glomerulosclerosis: A clinico-pathological study Open
CD44 immunostain can effectively distinguish MCNS from FSGS. The congruent results of CD44 positivity with known prognostic factors support the possibility of using the CD44 marker as a predictive tool in selecting high-risk patients and o…
View article: Pleomorphic adenoma of the external auditory canal
Pleomorphic adenoma of the external auditory canal Open
Pleomorphic adenoma (PA) of the external auditory canal (EAC) is a rare clinical entity with a few cases reported in the literature. The clinical diagnosis of these lesions can be formidable due to their rarity and unusual location. This t…
View article: A Rare Case of Extra-Ventricular Supra-Sellar Neurocytoma – A Diagnostic Conundrum
A Rare Case of Extra-Ventricular Supra-Sellar Neurocytoma – A Diagnostic Conundrum Open
The brain and its associated structures are often the primary source or site of metastases for many tumors. Neurocytoma is a relatively rare neuronal neoplasm, first described as an intra-ventricular tumor that is not known to be very aggr…
View article: AATF Inhibition Exerts Antiangiogenic Effects Against Human Hepatocellular Carcinoma
AATF Inhibition Exerts Antiangiogenic Effects Against Human Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC), a highly fatal cancer with a mortality rate proportional to its incidence, continues to pose a global health care challenge. Angiogenesis is a key factor in the growth and metastasis of hepatic tumors and th…
View article: AATF Inhibition Exerts Antiangiogenic Effects Against Human Hepatocellular Carcinoma
AATF Inhibition Exerts Antiangiogenic Effects Against Human Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC), a highly fatal cancer with a mortality rate proportional to its incidence, continues to pose a global health care challenge. Angiogenesis is a key factor in the growth and metastasis of hepatic tumors and th…
View article: <i>Unraveling the Potential Role of Tecomella undulata</i>in Experimental NASH
<i>Unraveling the Potential Role of Tecomella undulata</i>in Experimental NASH Open
Background and Aim The pathophysiology of NASH is complex owing to its diverse pathological drivers, and until recently, there were no approved drugs for this disease. Tecomella undulata is a popular herbal medicine used to treat hepatospl…
View article: Peripheral blood smear – An expeditious test in the preliminary diagnosis of bone marrow embolism in a case of multiple fractures: A case report
Peripheral blood smear – An expeditious test in the preliminary diagnosis of bone marrow embolism in a case of multiple fractures: A case report Open
Bone marrow embolism is known to occur after fractures of long bones such as the femur and pelvis. We report a case of multiple fractures in a 32-year-old female patient, demonstrating bone marrow elements in the peripheral blood as early …
View article: EVALUATING RISK FACTORS, CLINICAL AND THERAPEUTIC PROFILE OF STROKE PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL
EVALUATING RISK FACTORS, CLINICAL AND THERAPEUTIC PROFILE OF STROKE PATIENTS PRESENTING TO A TERTIARY CARE HOSPITAL Open
Objective: According to the World Health Organization, stroke is the second leading cause of death for people above the age of 60 years, and the fifth leading cause in people aged 15–59 years old. This study mainly aims to evaluate the pre…
View article: A study of Ki 67 immunostaining in breast carcinomas: Correlation with histopathological prognostic factors
A study of Ki 67 immunostaining in breast carcinomas: Correlation with histopathological prognostic factors Open
Background: One of the most common causes of carcinoma deaths among women is breast cancer. In view of the above, early diagnosis and effective treatment of the disease are immensely important. The increasing number of options for the trea…
View article: Thrombotic microangiopathy with pulmonary hemorrhage: A rare case report
Thrombotic microangiopathy with pulmonary hemorrhage: A rare case report Open
Thrombotic microangiopathy (TMA) includes various diseases with different etiologies which ultimately results in endothelial damage to the small vasculature leading to thrombosis in the micro vessels, this causes mechanical hemolysis, thro…
View article: Vascular endothelial growth factor expression in diabetic nephropathy; a clinico-pathological study
Vascular endothelial growth factor expression in diabetic nephropathy; a clinico-pathological study Open
Introduction: Diabetes is an illness of epidemic magnitude, and the figures are rising each year. Diabetic nephropathy (DN) is a dreaded long-term complication of diabetes and the most common reason for end-stage renal disease (ESRD). Micr…
View article: A Study of Ki 67 Immunostaining in Prostate Carcinomas: Correlation with Gleason’s Score
A Study of Ki 67 Immunostaining in Prostate Carcinomas: Correlation with Gleason’s Score Open
Background: One of the most common causes of carcinoma deaths among men is prostate cancer. In view of the above, early diagnosis and effective treatment of the disease are immensely important. The increasing number of options for the trea…
View article: Renal disease in human immunodeficiency virus infection; a divergent array
Renal disease in human immunodeficiency virus infection; a divergent array Open
Background: Renal disease is an important cause of morbidity and mortality in populations with HIV infection. Widespread use of combination antiretroviral therapy has altered the spectrum of renal disease. Studies among the HIV affected po…
View article: Spectrum of biopsy-proven kidney diseases at a tertiary care hospital in South India
Spectrum of biopsy-proven kidney diseases at a tertiary care hospital in South India Open
Introduction The prevalence of kidney diseases, glomerular and tubulointerstitial, varies with the geographical area, socioeconomic conditions of the people, population demographics, race and ethnicity, access to health care, and also the …
View article: A clinico-pathological study of lupus nephritis based on the International Society of Nephrology-Renal Pathology Society 2003 classification system
A clinico-pathological study of lupus nephritis based on the International Society of Nephrology-Renal Pathology Society 2003 classification system Open
INTRODUCTION: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). Renal involvement is a major determinant of the prognosis of SLE. The histological classification of LN is a key factor in determining the re…
View article: Evaluation of Nuclear Morphometry and Ki-67 Index in Clear Cell Renal Cell Carcinomas: a Five-Year Study
Evaluation of Nuclear Morphometry and Ki-67 Index in Clear Cell Renal Cell Carcinomas: a Five-Year Study Open
The CCRCC is an extremely heterogenous disease and clinical outcome is unpredictable despite several validated prognostic factors. The widely used Fuhrman nuclear grading is subjective, while nuclear morphometry, using computer assisted im…
View article: A Study of D2-40 Immunohistochemical Expression in Colorectal Carcinomas
A Study of D2-40 Immunohistochemical Expression in Colorectal Carcinomas Open
Background: Colorectal cancer is one of the most common cancers. Factors affecting survival include nodal positivity, lymphovascular invasion (LVI) and lymphangiogenesis (role in metastasis). Most endothelial markers stain lymphatics and b…
View article: Fine needle aspiration cytology of solitary fibrous tumor of the orbit
Fine needle aspiration cytology of solitary fibrous tumor of the orbit Open
Solitary fibrous tumor (SFT) is a distinct and a rare spindle cell neoplasm, commonly known to occur in the pleura and other serosal sites. With the advent of immunohistochemistry, varied extraserosal sites are being recognized as common l…
View article: Neonatal intramural calcification in jejunal atresia: Case report of a rare phenomenon
Neonatal intramural calcification in jejunal atresia: Case report of a rare phenomenon Open
Intramural calcification in intestinal atresia is a rare type of intra-abdominal calcification. The exact etiology of intramural calcification remains obscure. A 1-day-old newborn male baby presented with signs of intestinal obstruction an…