Sudha Kumari YOU? Author Swipe

Last 10y

Tubulin with a twist: Acetylated highways at the immune synapse Open

Srishti Mandal, Sudha Kumari · 2025

In this issue, (Aceitón et al. https://doi.org/10.1083/jcb.202407181) uncover a pathway that ties together rigidity sensing at the B cell immunological synapse to molecular shuttling of ATAT1, leading to microtubule acetylation and lysosom…

Insight into Alopecia: A Narrative Review of Prevalence, Pathogenesis and Psychological Consequences Open

Aparna Sharma, Sudha Kumari, Sharma Ak, A Ankita, R. K. Mishra , et al. · 2025

Alopecia, medically defined as hair loss or baldness, is a condition that results in partial or complete hair loss, primarily from the scalp. It can be caused by various factors including genetic predisposition, environmental triggers, che…

Limitations and potential of immunotherapy in ovarian cancer Open

Sandeep Kumar, Sayanti Acharya, Mahalakshmi Karthikeyan, Priyobrata Biswas, Sudha Kumari · 2024

Ovarian cancer (OC) is the third most common gynecological cancer and alone has an emergence rate of approximately 308,069 cases worldwide (2020) with dire survival rates. To put it into perspective, the mortality rate of OC is three times…

Reviewer #2 (Public Review): WASP facilitates tumor mechanosensitivity in T lymphocytes Open

Srishti Mandal, Mariane B. Melo, Pavlo Gordiichuk, Sayanti Acharya, Yeh‐Chuin Poh , et al. · 2023

Cytotoxic T lymphocytes (CTLs) carry out immunosurveillance by scanning target cells of diverse physical properties for the presence of antigens. While the recognition of cognate antigen by the T cell receptor is the primary signal for CTL…

Reviewer #1 (Public Review): WASP facilitates tumor mechanosensitivity in T lymphocytes Open

Srishti Mandal, Mariane B. Melo, Pavlo Gordiichuk, Sayanti Acharya, Yeh‐Chuin Poh , et al. · 2023

Cytotoxic T lymphocytes (CTLs) carry out immunosurveillance by scanning target cells of diverse physical properties for the presence of antigens. While the recognition of cognate antigen by the T cell receptor is the primary signal for CTL…

WASP facilitates tumor mechanosensitivity in T lymphocytes Open

Srishti Mandal, Mariane B. Melo, Pavlo Gordiichuk, Sayanti Acharya, Yeh‐Chuin Poh , et al. · 2023

Cytotoxic T lymphocytes (CTLs) carry out immunosurveillance by scanning target cells of diverse physical properties for the presence of antigens. While the recognition of cognate antigen by the T cell receptor is the primary signal for CTL…

Reviewer #3 (Public Review): WASP facilitates tumor mechanosensitivity in T lymphocytes Open

Srishti Mandal, Mariane B. Melo, Pavlo Gordiichuk, Sayanti Acharya, Yeh‐Chuin Poh , et al. · 2023

Cytotoxic T lymphocytes (CTLs) carry out immunosurveillance by scanning target cells of diverse physical properties for the presence of antigens. While the recognition of cognate antigen by the T cell receptor is the primary signal for CTL…

WASP facilitates tumor mechanosensitivity in T lymphocytes Open

Srishti Mandal, Mariane B. Melo, Pavlo Gordiichuk, Sayanti Acharya, Yeh‐Chuin Poh , et al. · 2023

Cytotoxic T lymphocytes (CTLs) carry out immunosurveillance by scanning target cells of diverse physical properties for the presence of antigens. While the recognition of cognate antigen by the T cell receptor is the primary signal for CTL…

WASP facilitates tumor mechanosensitivity in T lymphocytes Open

Srishti Mandal, Mariane B. Melo, Pavlo Gordiichuk, Sayanti Acharya, Yeh‐Chuin Poh , et al. · 2023

Cytotoxic T lymphocytes (CTLs) carry out immunosurveillance by scanning target cells of diverse physical properties for the presence of antigens. While the recognition of cognate antigen by the T cell receptor is the primary signal for CTL…

Association of metabolic syndrome and endometrial pathologies in postmenopausal women Open

Kiran Pandey, Sudha Kumari, Pavika Lal, Garima Gupta, Ajay Bhagoliwal · 2023

Background: The menopausal state may predispose the women to the development of metabolic syndrome as its prevalence has been reported to increase after the attainment of menopause. The aim of this study was to determine the prevalence of …

Editorial: Cytoskeletal Regulation of Immune Response Open

Sudha Kumari, Wolfgang W. Schamel, Balbino Alarcón · 2021

EDITORIAL article Front. Cell Dev. Biol., 04 November 2021Sec. Cell Growth and Division https://doi.org/10.3389/fcell.2021.791327

Study of association of socio-demographic characteristics with the knowledge about sex determination and preconception and prenatal diagnostic technique act among pregnant women Open

Seema Dwivedi, Garima Gupta, Sudha Kumari, Bandana Sharma · 2021

Background: Preconception and prenatal diagnostic technique Act was amended in year 2003 which provides for prohibition of sex selection before and after conception and for regulation of prenatal diagnostic technique.Methods: A cross secti…

STRESS, COPING, AND RESILIENCE: INTEGRATING PSYCHOLOGICAL AND NEURO-SCIENTIFIC INSIGHTS FOR OCCUPATIONAL THERAPY Open

Sudha Kumari · 2020

Author Correction: Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity Open

Alexandra Zanin‐Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan , et al. · 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact Open

Sudha Kumari, Michael Mak, Yeh‐Chuin Poh, Mira Tohmé, Nicki Watson , et al. · 2020

When migratory T cells encounter antigen-presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information and are cr…

DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering Open

Vinay S. Mahajan, Ezana Demissie, Faisal Alsufyani, Sudha Kumari, Grace J. Yuen , et al. · 2019

The control of cytoskeletal dynamics by dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell–specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified …

Not All T Cell Synapses Are Built the Same Way Open

Sudha Kumari, Huw Colin‐York, Darrell J. Irvine, Marco Fritzsche · 2019

T cells comprise functionally diverse subtypes. Although activated via a conserved scheme of antigen recognition by their T cell receptor, they elicit heterogeneous activation and effector responses. Such functional diversity has been appr…

Distinct actin cytoskeleton behaviour in primary and immortalised T-cells Open

Huw Colin‐York, Sudha Kumari, Liliana Barbieri, Lena Cords, Marco Fritzsche · 2019

Cytoskeletal actin dynamics are crucial for the activation of T-cells. Immortalised Jurkat T-cells have been the model system of choice to examine and correlate the dynamics of the actin cytoskeleton and the immunological synapse leading t…

Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor Open

Leyuan Ma, Tanmay Dichwalkar, Jason Y.H. Chang, Benjamin Cossette, Daniel Garafola , et al. · 2019

A boost for CAR–T cells Chimeric antigen receptor (CAR)–T cell immunotherapy has been highly successful for treating certain blood cancers. Yet this approach has been a challenge for solid tumors, in part because it is difficult to target …

DOCK2 sets the threshold for entry into the virtual memory CD8<sup>+</sup>T cell compartment by negatively regulating tonic TCR triggering Open

Ezana Demissie, Vinay S. Mahajan, Faisal Alsufyani, Sudha Kumari, Grace J. Yuen , et al. · 2019

The control of cytoskeletal dynamics by Dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in Dock2 have been identified …

Cytoskeletal Control of Antigen-Dependent T Cell Activation Open

Huw Colin‐York, Yousef Javanmardi, Mark Skamrahl, Sudha Kumari, Veronica T. Chang , et al. · 2019

Cytoskeletal actin dynamics is essential for T cell activation. Here, we show evidence that the binding kinetics of the antigen engaging the T cell receptor influences the nanoscale actin organization and mechanics of the immune synapse. U…

Probing the Role of HIV Antigen Nanoscale Organization on B-Cell Activation with DNA Origami Open

Rémi Veneziano, Tyson J. Moyer, Matthew B. Stone, Sudha Kumari, William R. Schief , et al. · 2019

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers Open

Talar Tokatlian, Benjamin J. Read, Christopher A. Jones, Daniel W. Kulp, Sergey Menis , et al. · 2018

HIV glycans and nanoparticle vaccines Synthetic nanoparticles have attracted widespread interest for vaccine design, but how the immune system generates a response to multimeric nanoparticles remains unclear. Tokatlian et al. studied immun…

Cytoskeletal tension actively sustains the migratory T cell synaptic contact Open

Sudha Kumari, Michael Mak, Yeh‐Chuin Poh, Mira Tohmé, Nicki Watson , et al. · 2018

Summary When migratory T cells encounter antigen presenting cells (APCs), they arrest and form radially symmetric, stable intercellular junctions termed immunological synapses which facilitate exchange of crucial biochemical information an…

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease Open

Cameron McDonald-Hyman, James Muller, Michaël Loschi, Govindarajan Thangavelu, Asim Saha , et al. · 2018

Regulatory T cells (Tregs) are critical for maintaining immune homeostasis. However, current Treg immunotherapies do not optimally treat inflammatory diseases in patients. Understanding the cellular processes that control Treg function may…

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs Open

Erin Janssen, Sudha Kumari, Mira Tohmé, Sumana Ullas, Víctor Barrera , et al. · 2017

Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8-/- mice have de…

Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity Open

Alexandra Zanin‐Zhorov, Sudha Kumari, Keli L. Hippen, Sarah C. Merkel, Margaret L. MacMillan , et al. · 2017

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells Open

R. Brad Jones, Stephanie Mueller, Sudha Kumari, Vlad Vrbanac, Shy Genel , et al. · 2016

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses Open

Kelly D. Moynihan, Cary F. Opel, Gregory L. Szeto, Alice Tzeng, Eric Zhu , et al. · 2016

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination Open

Hok Hei Tam, Mariane B. Melo, Myungsun Kang, Jeisa M. Pelet, Vera M. Ruda , et al. · 2016

Significance We explored the effect of nontraditional vaccine dosing profiles on antibody titers of vaccines and discovered that certain dosing profiles demonstrate >10-fold higher antibody production than the traditional single-dose prime…

Fetching topic information...