Sudhir Thakurela
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View article: Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion
Long Noncoding RNAs Preserve Pancreatic Cancer Identity and Resist Cell Fate Conversion Open
Summary The Yamanaka factors (OCT4, SOX2, KLF4, and MYC; OSKM) can rejuvenate aging phenotypes in somatic cell types by resetting the epigenetic landscape. Curiously, most solid tumor cells remain largely resistant to reprogramming despite…
View article: Cellular mechanisms of early brain overgrowth in autistic children: elevated levels of GPX4 and resistance to ferroptosis
Cellular mechanisms of early brain overgrowth in autistic children: elevated levels of GPX4 and resistance to ferroptosis Open
Autistic individuals with disproportionate megalencephaly (ASD-DM), characterized by enlarged brains relative to body height, have higher rates of intellectual disability and face more severe cognitive challenges than autistic children wit…
View article: Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration Open
View article: Stromal-cell deletion of STAT3 protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
Stromal-cell deletion of STAT3 protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration Open
SUMMARY Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor implicated in the pathogenesis of kidney fibrosis. Although tubular Stat3 deletion in tubular epithelial cells is known to protect mice from k…
View article: Stromal-Cell Deletion of STAT3 Protects Mice from Kidney Fibrosis by Inhibiting Pericytes Trans-Differentiation and Migration
Stromal-Cell Deletion of STAT3 Protects Mice from Kidney Fibrosis by Inhibiting Pericytes Trans-Differentiation and Migration Open
View article: Fatty changes associated with N-Nitrosodiethylamine (DEN) induced hepatocellular carcinoma: A role of sonic hedgehog signaling pathway
Fatty changes associated with N-Nitrosodiethylamine (DEN) induced hepatocellular carcinoma: A role of sonic hedgehog signaling pathway Open
Our results revealed an unknown aspect of SHH pathway in hepatocarcinogenesis via its control over lipogenesis. It gives insight into the lipogenic properties of DEN+CCl4 induced rodent hepatocarcinogenesis model and how SHH pathway operat…
View article: Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
Differential regulation of OCT4 targets facilitates reacquisition of pluripotency Open
Ectopic transcription factor expression enables reprogramming of somatic cells to pluripotency, albeit with generally low efficiency. Despite steady progress in the field, the exact molecular mechanisms that coordinate this remarkable tran…
View article: The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways
The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways Open
Our data uncovers the grade related expression of Wnt and Hh pathway molecules and the potential utility of these molecular signatures in daily clinical practice is to decide best therapy according to patients characteristic. Additionally,…
View article: Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes
Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes Open
A broad molecular framework of how neural stem cells are specified toward astrocyte fate during brain development has proven elusive. Here we perform comprehensive and integrated transcriptomic and epigenomic analyses to delineate gene reg…
View article: Genetic determinants and epigenetic effects of pioneer-factor occupancy
Genetic determinants and epigenetic effects of pioneer-factor occupancy Open
View article: Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes
Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes Open
The thalamus is a central brain structure with topographically ordered long-range axonal projections that convey sensory information to the cortex via distinct nuclei. Although there is an increasing knowledge about genes important for tha…
View article: The transcriptome of mouse central nervous system myelin
The transcriptome of mouse central nervous system myelin Open
View article: Mapping gene regulatory circuitry of Pax6 during neurogenesis
Mapping gene regulatory circuitry of Pax6 during neurogenesis Open
View article: Identifying Novel Transcriptional Regulators with Circadian Expression
Identifying Novel Transcriptional Regulators with Circadian Expression Open
Organisms adapt their physiology and behavior to the 24-h day-night cycle to which they are exposed. On a cellular level, this is regulated by intrinsic transcriptional-translational feedback loops that are important for maintaining the ci…
View article: Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity
Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity Open
Gene regulation in mammals involves a complex interplay between promoters and distal regulatory elements that function in concert to drive precise spatiotemporal gene expression programs. However, the dynamics of the distal gene regulatory…
View article: <scp>JNK</scp> ‐dependent gene regulatory circuitry governs mesenchymal fate
<span>JNK</span> ‐dependent gene regulatory circuitry governs mesenchymal fate Open
View article: Dynamics of chromatin accessibility and epigenetic state in response to UV damage
Dynamics of chromatin accessibility and epigenetic state in response to UV damage Open
Epigenetic mechanisms determine the access of regulatory factors to DNA during events such as transcription and DNA damage response. However, the global response of histone modifications and chromatin accessibility to UV exposure remains p…