Sudip Dhakal
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View article: Simvastatin, Its Antimicrobial Activity and Its Prevention of Alzheimer’s Disease
Simvastatin, Its Antimicrobial Activity and Its Prevention of Alzheimer’s Disease Open
Simvastatin, a blockbuster drug for treating hypercholesterolemia, has multifactorial benefits as an antimicrobial agent and plays a preventative role in reducing the incidence of Alzheimer’s Disease (AD). Although most of the beneficial e…
View article: The Use of Yeast in Biosensing
The Use of Yeast in Biosensing Open
Yeast has been used as a model for several diseases as it is the simplest unicellular eukaryote, safe and easy to culture and harbors most of the fundamental processes that are present in almost all higher eukaryotes, including humans. Fro…
View article: ‘The awesome power of yeast’
‘The awesome power of yeast’ Open
Yeast is one of the most useful microorganisms in society. Aside from the well known traditional uses in beer, wine and bread making, yeast is currently providing new opportunities for our society. This article examines some of those new o…
View article: Finding effective combinations of compounds to prevent Alzheimer’s disease
Finding effective combinations of compounds to prevent Alzheimer’s disease Open
Alzheimer’s disease (AD) remains one of the significant causes of death and morbidity in the older population (2021). The cause of AD remains unclear despite there being numerous hypotheses. Perhaps the most widely accepted hypothesis is t…
View article: ‘The awesome power of yeast’ in Alzheimer’s disease research
‘The awesome power of yeast’ in Alzheimer’s disease research Open
The difficulties in performing experimental studies related to diseases of the human brain have fostered a range of disease models from highly expensive and complex animal models to simple, robust, unicellular yeast models. Yeast models ha…
View article: Trans-Chalcone Plus Baicalein Synergistically Reduce Intracellular Amyloid Beta (Aβ42) and Protect from Aβ42 Induced Oxidative Damage in Yeast Models of Alzheimer’s Disease
Trans-Chalcone Plus Baicalein Synergistically Reduce Intracellular Amyloid Beta (Aβ42) and Protect from Aβ42 Induced Oxidative Damage in Yeast Models of Alzheimer’s Disease Open
Finding an effective therapeutic to prevent or cure AD has been difficult due to the complexity of the brain and limited experimental models. This study utilized unmodified and genetically modified Saccharomyces cerevisiae as model organis…
View article: Lipids, statins and susceptibility to SARS-CoV-2 and influenza A viruses
Lipids, statins and susceptibility to SARS-CoV-2 and influenza A viruses Open
The extensive and on-going epidemiology studies of the SARS-CoV-2 pandemic have raised interesting observations on statins reducing COVID-19 severity. In this review, literature is analysed to examine how statins affect COVID-19 and influe…
View article: Genes of SARS-CoV-2 and emerging variants
Genes of SARS-CoV-2 and emerging variants Open
The pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is distinctly different from outbreaks caused by other coronaviruses: SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). The differences…
View article: A Toxic Synergy between Aluminium and Amyloid Beta in Yeast
A Toxic Synergy between Aluminium and Amyloid Beta in Yeast Open
Alzheimer’s disease (AD), the most prevalent, age-related, neurodegenerative disease, is associated with the accumulation of amyloid beta (Aβ) and oxidative stress. However, the sporadic nature of late-onset AD has suggested that other fac…
View article: Volume 42 Number 1
Volume 42 Number 1 Open
It is timely to assess where we are in the current SARS Coronavirus-2 pandemic.This edition of Microbiology Australia has national, and international, authorities authoring a series of papers on SARS Coronavirus 2 and related subjects.We a…
View article: Potential contributions of trace amines in Alzheimer’s disease and therapeutic prospects
Potential contributions of trace amines in Alzheimer’s disease and therapeutic prospects Open
View article: Tyramine and amyloid beta 42: A toxic synergy
Tyramine and amyloid beta 42: A toxic synergy Open
Background In synaptic cleft, trace amines play a crucial role as neurotransmitter signaling through the trace amine associated receptors. Tyramine, an important trace amine formed by decarboxylation of tyrosine, has been reported to be im…
View article: Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer’s Disease
Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer’s Disease Open
Alzheimer’s Disease (AD) is a progressive multifactorial age-related neurodegenerative disorder that causes the majority of deaths due to dementia in the elderly. Although various risk factors have been found to be associated with AD progr…
View article: Yeast contributions to Alzheimer’s Disease
Yeast contributions to Alzheimer’s Disease Open
Alzheimer's Disease is a highly prevalent, age-related, neurodegenerative disease associated with the accumulation of toxic proteins, including amyloid beta and tau, that affect important cellular functions
View article: Tyramine and Amyloid Beta 42: A Toxic Synergy
Tyramine and Amyloid Beta 42: A Toxic Synergy Open
Implicated in various diseases including Parkinson’s disease, Huntington’s disease, migraines, schizophrenia and increased blood pressure, tyramine plays a crucial role as a neurotransmitter in the synaptic cleft by reducing serotonergic a…
View article: Siccibacter turicensis from Kangaroo Scats: Possible Implication in Cellulose Digestion
Siccibacter turicensis from Kangaroo Scats: Possible Implication in Cellulose Digestion Open
Microbiota in the kangaroo gut degrade cellulose, contributing to the kangaroo’s energy and survival. In this preliminary study, to discover more about the gut microbes that contribute to the survival of kangaroos, cellulose-degrading bact…
View article: ZIF Polymorphs for Nucleic Acid Delivery and Targeted Knockdown of Gene Expression in Prostate Cancer
ZIF Polymorphs for Nucleic Acid Delivery and Targeted Knockdown of Gene Expression in Prostate Cancer Open
Prostate cancer (PC) is the second leading cause of male cancer deaths, the advanced form of which continues to be incurable; and nature of the disease being such that it is highly suitable for gene therapy. However, therapy is hampered by…
View article: ZIF Polymorphs for Nucleic Acid Delivery and Targeted Knockdown of Gene Expression in Prostate Cancer
ZIF Polymorphs for Nucleic Acid Delivery and Targeted Knockdown of Gene Expression in Prostate Cancer Open
Prostate cancer (PC) is the second leading cause of male cancer deaths, the advanced form of which continues to be incurable; and nature of the disease being such that it is highly suitable for gene therapy. However, therapy is hampered by…
View article: Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease
Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease Open
Ageing is an inevitable fundamental process for people and is their greatest risk factor for neurodegenerative disease. The ageing processes bring changes in cells that can drive the organisms to experience loss of nutrient sensing, disrup…
View article: Gene Therapy: Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8) (Small 36/2019)
Gene Therapy: Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8) (Small 36/2019) Open
Gene therapy utilizing non-viral delivery systems still lags behind its viral counterpart despite being the safer method. In article number 1902268, Ravi Shukla and co-workers explore the potential of metal–organic frameworks (MOFs) for ge…
View article: Simvastatin Efficiently Reduces Levels of Alzheimer’s Amyloid Beta in Yeast
Simvastatin Efficiently Reduces Levels of Alzheimer’s Amyloid Beta in Yeast Open
A large-scale epidemiology study on statins previously showed that simvastatin was unique among statins in reducing the incidence of dementia. Since amyloid beta (Aβ42) is the protein that is most associated with Alzheimer’s disease, this …
View article: Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5
Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5 Open
The yeast, Saccharomyces cerevisiae, the model eukaryote, has provided much understanding of molecular and cellular biology, as well as insights into many human diseases. In this paper we review how yeast studies are contributing …
View article: Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8)
Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8) Open
Recent work in biomolecule-metal–organic framework (MOF) composites have proven to be an effective strategy for the protection of proteins. However, for other biomacromolecules such as nucleic acids, the encapsulation into MOFs and the rel…
View article: Clearing Deleterious Proteins for Healthier Aging
Clearing Deleterious Proteins for Healthier Aging Open
The build-up of deleterious proteins is one of the biggest problems in aging. The brain, the organ most sensitive to this phenomenon, seeks to maintain the correct balance by the process known as proteostasis but this process declines with…