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View article: Targeting the P10 Peptide in Maturing Dendritic Cells via the DEC205 Receptor In Vivo: A New Therapeutic Strategy against Paracoccidioidomycosis
Targeting the P10 Peptide in Maturing Dendritic Cells via the DEC205 Receptor In Vivo: A New Therapeutic Strategy against Paracoccidioidomycosis Open
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a thermally dimorphic fungus, which is the most frequent endemic systemic mycosis in many Latin American countries, where ~10 million people are be…
View article: Peptidorhamnomannan from Lomentospora prolificans modulates the inflammatory response in macrophages infected with Candida albicans
Peptidorhamnomannan from Lomentospora prolificans modulates the inflammatory response in macrophages infected with Candida albicans Open
View article: Insulin Modulates <i>Paracoccidioides brasiliensis</i>-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs
Insulin Modulates <i>Paracoccidioides brasiliensis</i>-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs Open
Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients. We evaluated the role of insulin in inflammatory parameters in diabetic and n…
View article: A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis
A Model for Trans-Kingdom Pathogenicity in Fonsecaea Agents of Human Chromoblastomycosis Open
The fungal genus Fonsecaea comprises etiological agents of human chromoblastomycosis, a chronic implantation skin disease. The current hypothesis is that patients acquire the infection through an injury from plant material. The pres…
View article: The importance of Toll-like receptor 4 during experimental<i>Sporothrix brasiliensis</i>infection
The importance of Toll-like receptor 4 during experimental<i>Sporothrix brasiliensis</i>infection Open
Here we investigated the importance of Toll-like receptor 4 (TLR-4) in innate immune response to Sporothrix brasiliensis, a virulent fungus of Sporothrix spp. In vitro assays, using C57Bl/6 (wild type [WT]) bone marrow-derived macrophages …
View article: Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis
Notch Signaling is Required for Dendritic Cell Maturation and T Cell Expansion in Paracoccidioidomycosis Open
View article: Comparative Genomics of Sibling Species of Fonsecaea Associated with Human Chromoblastomycosis
Comparative Genomics of Sibling Species of Fonsecaea Associated with Human Chromoblastomycosis Open
Fonsecaea and Cladophialophora are genera of black yeast-like fungi harboring agents of a mutilating implantation disease in humans, along with strictly environmental species. The current hypothesis suggests that those specie…
View article: Infection with Paracoccidioides brasiliensis induces B-1 cell migration and activation of regulatory T cells
Infection with Paracoccidioides brasiliensis induces B-1 cell migration and activation of regulatory T cells Open
View article: Increase in virulence of<i>Sporothrix brasiliensis</i>over five years in a patient with chronic disseminated sporotrichosis
Increase in virulence of<i>Sporothrix brasiliensis</i>over five years in a patient with chronic disseminated sporotrichosis Open
The metropolitan region of Rio de Janeiro is hyperendemic for cat-associated sporotrichosis. This study aimed to assess the virulence of serial Sporothrix isolates from a 61-year-old male patient with chronic, destructive disseminated spor…