John H. Suh
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View article: CTNI-29. MOLECULAR ANALYSIS OF OUTCOMES IN ECOG-ACRIN E3F05: PHASE III STUDY OF RADIATION THERAPY WITH OR WITHOUT TEMOZOLOMIDE FOR SYMPTOMATIC OR PROGRESSIVE LOW-GRADE GLIOMAS
CTNI-29. MOLECULAR ANALYSIS OF OUTCOMES IN ECOG-ACRIN E3F05: PHASE III STUDY OF RADIATION THERAPY WITH OR WITHOUT TEMOZOLOMIDE FOR SYMPTOMATIC OR PROGRESSIVE LOW-GRADE GLIOMAS Open
BACKGROUND The phase III ECOG-ACRIN E3F05 trial tested whether combined therapy with radiation and concomitant followed by adjuvant temozolomide is more effective than radiation alone in patients with grade II gliomas. The study incorporat…
RADT-15. CLINICAL OUTCOMES OF PATIENTS WITH BRAIN METASTASES FROM SMALL CELL LUNG CANCER TREATED WITH STEREOTACTIC RADIOSURGERY Open
BACKGROUND Whole brain radiation therapy (WBRT) has historically been standard treatment for brain metastases (BM) from small cell lung cancer (SCLC). Stereotactic radiosurgery (SRS) is increasingly used as an upfront approach. We report i…
View article: Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver
Single-Cell Multiomic Analysis of Circadian Rhythmicity in Mouse Liver Open
Circadian rhythms are remarkably widespread across most organisms, regulating hormonal, metabolic, physiological, and behavioral oscillations through molecular clocks that orchestrate the rhythmic expression of thousands of genes. Here, we…
View article: Large vestibular schwannoma treated using a cranial nerve sparing approach with planned subtotal microsurgical resection and stereotactic radiosurgery: meta-analysis and International Stereotactic Radiosurgery Society (ISRS) practice guidelines
Large vestibular schwannoma treated using a cranial nerve sparing approach with planned subtotal microsurgical resection and stereotactic radiosurgery: meta-analysis and International Stereotactic Radiosurgery Society (ISRS) practice guidelines Open
Introduction Stereotactic radiosurgery (SRS) has become a standard of care for small- to medium- size vestibular schwannomas (VS), while the majority of patients with large VS still require microsurgical resection due to potential conseque…
Expedited chemoradiation after laser interstitial thermal therapy (LITT) is feasible and safe in patients with newly diagnosed glioblastoma Open
Background High-grade gliomas (HGG) are incurable primary brain tumors. Laser interstitial thermal therapy (LITT) has emerged as an alternative to surgery for select patients. Hyperthermia can improve the efficacy of radiation and chemothe…
View article: Outcomes of Adjuvant Radiation Treatment Following Subtotal Resection of World Health Organization Grade II Meningiomas
Outcomes of Adjuvant Radiation Treatment Following Subtotal Resection of World Health Organization Grade II Meningiomas Open
Purpose: Existing literature on adjuvant radiation after subtotal resection (STR) of WHO II meningiomas is limited by heterogenous patient cohorts, combining adjuvant and salvage radiation, gross total resection (GTR) and STR, primary radi…
CTNI-52. EXPEDITED CHEMORADIATION AFTER LASER INTERSTITIAL THERMAL THERAPY (LITT) IS FEASIBLE AND SAFE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA Open
BACKGROUND High-grade gliomas (HGG) are incurable primary brain tumors. Laser Interstitial Thermal Therapy (LITT) has emerged as an alternative to surgery for select patients. Hyperthermia can improve the efficacy of radiation and chemothe…
LTBK-07. PROGRESSION-FREE AND OVERALL SURVIVAL RESULTS OF ECOG-ACRIN E3F05: A PHASE 3 INTERGROUP TRIAL OF RADIATION ± TEMOZOLOMIDE FOR GRADE II GLIOMAS Open
BACKGROUND Both radiation and temozolomide (TMZ) have meaningful single-modality anti-tumor activity against low-grade gliomas. ECOG-ACRIN E3F05 tested whether combined therapy with radiation and temozolomide is more effective than radiati…
View article: The Role of CT and MR Imaging in Stereotactic Body Radiotherapy of the Spine: From Patient Selection and Treatment Planning to Post-Treatment Monitoring
The Role of CT and MR Imaging in Stereotactic Body Radiotherapy of the Spine: From Patient Selection and Treatment Planning to Post-Treatment Monitoring Open
Spine metastases (SMs) are common, arising in 70% of the cases of the most prevalent malignancies in males (prostate cancer) and females (breast cancer). Stereotactic body radiotherapy, or SBRT, has been incorporated into clinical treatmen…
View article: Pediatric cranial stereotactic radiosurgery: Meta-analysis and international stereotactic radiosurgery society practice guidelines
Pediatric cranial stereotactic radiosurgery: Meta-analysis and international stereotactic radiosurgery society practice guidelines Open
Background There are limited data on the use of stereotactic radiosurgery (SRS) for pediatric patients. The aim of this systematic review was to summarize indications and outcomes specific to pediatric cranial SRS to inform consensus guide…
OCTS-01 DOSE ESCALATION FOR PREOPERATIVE STEREOTACTIC RADIOSURGERY FOR PATIENTS WITH LARGE BRAIN METASTASES Open
PURPOSE/OBJECTIVE(S) We conducted a prospective phase I preoperative radiosurgery dose escalation trial for brain metastases greater than 2 cm. We report updated results with known prognostic variables. MATERIALS/METHODS Radiosurgery dose …
View article: IMUN-08 DURABLE RESPONSE TO IPILIMUMAB-NIVOLUMAB (IPI-NIVO) IN ANTI-PD1 REFRACTORY MERKEL CELL CARCINOMA WITH LEPTOMENINGEAL DISEASE PROGRESSION
IMUN-08 DURABLE RESPONSE TO IPILIMUMAB-NIVOLUMAB (IPI-NIVO) IN ANTI-PD1 REFRACTORY MERKEL CELL CARCINOMA WITH LEPTOMENINGEAL DISEASE PROGRESSION Open
Leptomeningeal disease (LMD) is a rare complication of Merkel cell carcinoma (MCC), which has been described in limited case reports, none of which describe outcomes with IPI-NIVO. Here we describe a patient with PD-1 refractory MCC LMD wi…
Phase I trial of dose escalation for preoperative stereotactic radiosurgery for patients with large brain metastases Open
Background Single-session stereotactic radiosurgery (SRS) or surgical resection alone for brain metastases larger than 2 cm results in unsatisfactory local control. We conducted a phase I trial for brain metastases(>2 cm) to determine the …
(276) Light Emitting Diodes (LED) as a Potential Therapy for Erectile Function: A Preclinical Study in a Cavernous Nerve Injury Model Open
Introduction Erectile dysfunction (ED) induced by nerve injury including prostatectomy poorly responds to PDE5 inhibitor and requires invasive treatment. Light emitting diodes (LED) in some spectral range, is able to irradiate cells withou…
View article: The dilemma of radiation necrosis from diagnosis to treatment in the management of brain metastases
The dilemma of radiation necrosis from diagnosis to treatment in the management of brain metastases Open
Radiation therapy with stereotactic radiosurgery (SRS) or whole brain radiation therapy is a mainstay of treatment for patients with brain metastases. The use of SRS in the management of brain metastases is becoming increasingly common and…
View article: (275) IGFBP5 Short Hairpin RNA (shRNA) Constructs Improve Erectile Function in a Mouse Model of Cavernous Nerve Injury
(275) IGFBP5 Short Hairpin RNA (shRNA) Constructs Improve Erectile Function in a Mouse Model of Cavernous Nerve Injury Open
Introduction Radical prostatectomy for prostate cancer not only induces cavernous nerve injury but also causes cavernous angiopathy, which is responsible for poor responsiveness to phosphodiesterase-5 inhibitors. Insulin-like growth factor…
Using standardized workflows and quantitative data‐driven management to reduce time interval from simulation to treatment initiation Open
Purpose External beam radiotherapy is a complex process, involving timely coordination among multiple teams. The aim of this study is to report our experience of establishing a standardized workflow and using quantitative data and metrics …
Comprehensive assessment of proton plans with three different beam delivery systems for multiple brain metastases. Open
The LPB and LPMB stand as excellent alternatives to CPB or photon therapy and significantly increase the preservation of normal tissue.
Management of sporadic intracanalicular vestibular schwannomas: A critical review and International Stereotactic Radiosurgery Society (ISRS) practice guidelines Open
Background The choice of an appropriate strategy for intracanalicular vestibular schwannoma (ICVS) is still debated. We conducted a systematic review and meta-analysis with the aim to compare treatment outcomes amongst management strategie…
CTNI-21. PHASE I STUDY OF BTK INHIBITOR IBRUTINIB WITH TEMOZOLOMIDE AND RADIATION IN NEWLY-DIAGNOSED GLIOBLASTOMA (EQUILIBRIUM): FINAL TRIAL REPORT Open
BACKGROUND Glioblastoma carries dismal prognosis for which novel therapeutics are urgently needed. Ibrutinib, an oral small molecule inhibitor of BTK, has been shown in preclinical models to inhibit cancer stem cells in glioblastoma. We so…
INNV-08. LONG-TERM GLOBAL POST-MARKETING SAFETY SURVEILLANCE DATA FROM PEDIATRIC, ADULT AND ELDERLY PATIENTS WITH CENTRAL NERVOUS SYSTEM MALIGNANCIES TREATED WITH TUMOR TREATING FIELDS (TTFIELDS) THERAPY Open
BACKGROUND Glioblastoma (GBM) is an aggressive central nervous system (CNS) malignancy with poor prognosis. TTFields are electric fields that exert physical forces to disrupt cellular processes critical for cancer cell viability. TTFields …
CTNI-09. DOSE ESCALATION FOR NEOADJUVANT STEREOTACTIC RADIOSURGERY FOR LARGE BRAIN METASTASES: PHASE I RESULTS Open
BACKGROUND Surgical resection may be required for large and symptomatic brain metastases. Adjuvant radiotherapy or stereotactic radiosurgery (SRS) is needed to reduce local recurrence. Adjuvant radiosurgery has been associated with higher …