Shao‐Nong Chen
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View article: Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins
Advanced biomechanics and stability of the resin-dentin complex via modular A- and B-type proanthocyanidins Open
This study explored the formation and sustainability of the resin-dentin complex optimized by four proanthocyanidins (PACs), modularly defined catechin oligomers with distinct single (B-type) or double (A-type) interflavanyl linkages (IFLs…
View article: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research Open
Covering: up to 2018With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw…
View article: Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research Open
Correction for 'The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research'
View article: Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues
Structure-Based Analysis of Semisynthetic Anti-TB Rufomycin Analogues Open
This study employed structural information from cocrystals of rufomycin 4 (1a) and caseinolytic protein C1 (ClpC1)-NTD-wt to guide design and semisynthesis of rufomycin analogues, evaluate their antituberculosis (TB) biological profiles, a…
View article: Multi-dimensional social relationships shape social attention in monkeys
Multi-dimensional social relationships shape social attention in monkeys Open
Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, and multidimensional social relationships, which form interwoven social networks, reflecting …
View article: Regulatory Potency of Oligomeric Proanthocyanidins (<scp>PACs</scp>) on Extrafibrillar and Intrafibrillar Collagen Mineralization
Regulatory Potency of Oligomeric Proanthocyanidins (<span>PACs</span>) on Extrafibrillar and Intrafibrillar Collagen Mineralization Open
The therapeutic potential of plant‐derived proanthocyanidins (PACs) interacting with mammalian collagen is extensive, notably in strengthening specialized extracellular matrix like the dentin matrix, crucial for reparative dental treatment…
View article: Multi-dimensional social relationships shape social attention in monkeys
Multi-dimensional social relationships shape social attention in monkeys Open
Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, and multidimensional social relationships, which form interwoven social networks, reflecting …
View article: Multi-dimensional social relationships shape social attention in monkeys
Multi-dimensional social relationships shape social attention in monkeys Open
Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, and multidimensional social relationships, which form interwoven social networks, reflecting …
View article: Multi-dimensional social relationships shape social attention in monkeys
Multi-dimensional social relationships shape social attention in monkeys Open
Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, and multidimensional social relationships, which form interwoven social networks, reflecting …
View article: WITHDRAWN: Feasibility of using Gag proteins to reawaken dormant HIV infection based on bioinformatics analysis
WITHDRAWN: Feasibility of using Gag proteins to reawaken dormant HIV infection based on bioinformatics analysis Open
The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
View article: Chemical Transformation of B- to A-type Proanthocyanidins and 3D Structural Implications
Chemical Transformation of B- to A-type Proanthocyanidins and 3D Structural Implications Open
In nature, proanthocyanidins (PACs) with A-type linkages are relatively rare, likely due to biosynthetic constraints in the formation of additional ether bonds to be introduced into the more common B-type precursors. However, A-type linkag…
View article: Bitter taste sensitivity and frequency of bitter food intake in healthy Australian adults: a cross-sectional, mixed-methods study
Bitter taste sensitivity and frequency of bitter food intake in healthy Australian adults: a cross-sectional, mixed-methods study Open
Bitter taste perception plays a dual role in human nutrition and evolutionary biology; being identifiable in nutrient-dense foods such as cruciferous vegetables and historically signalled toxic compounds. The TAS2R38 gene, part of the tast…
View article: Modulatory role of terminal monomeric flavan‐3‐ol units in the viscoelasticity of dentin
Modulatory role of terminal monomeric flavan‐3‐ol units in the viscoelasticity of dentin Open
Flavan‐3‐ol monomers are the building blocks of proanthocyanidins (PACs), natural compounds from plants shown to mediate specific biologic activities on dentin. While the stereochemistry of the terminal flavan‐3‐ols, catechin (C) versus ep…
View article: Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins
Unprecedented Benzoquinone Motifs Reveal Post-Oligomerizational Modification of Proanthocyanidins Open
Proanthocyanidins (PACs) are complex flavan-3-ol polymers with stunning chemical complexity due to oxygenation patterns, oxidative phenolic ring linkages, and intricate stereochemistry of their heterocycles and inter-flavan linkages. Being…
View article: Supplementary Figures 1-3 from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
Supplementary Figures 1-3 from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A) Open
PDf file - 294K
View article: Data from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
Data from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A) Open
Long-term exposure to estrogens including those in traditional hormone replacement therapy (HRT) increases the risk of developing hormone-dependent cancers. As a result, women are turning to over-the-counter (OTC) botanical dietary supplem…
View article: Data from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
Data from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A) Open
Long-term exposure to estrogens including those in traditional hormone replacement therapy (HRT) increases the risk of developing hormone-dependent cancers. As a result, women are turning to over-the-counter (OTC) botanical dietary supplem…
View article: Supplementary Figures 1-3 from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A)
Supplementary Figures 1-3 from Hops (<i>Humulus lupulus</i>) Inhibits Oxidative Estrogen Metabolism and Estrogen-Induced Malignant Transformation in Human Mammary Epithelial cells (MCF-10A) Open
PDf file - 294K
View article: Geraniol-Derived Monoterpenoid Glucosides from <i>Rhodiola rosea</i>: Resolving Structures by QM-HifSA Methodology
Geraniol-Derived Monoterpenoid Glucosides from <i>Rhodiola rosea</i>: Resolving Structures by QM-HifSA Methodology Open
Monoterpenoids are integral to the chemical composition of the widely used adaptogenic dietary supplement Rhodiola rosea. The present study expands the chemical space and stereochemical information about these taxon-specific constituents f…
View article: <i>Seco</i> B-Type Oligomers from <i>Pinus massoniana</i> Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity
<i>Seco</i> B-Type Oligomers from <i>Pinus massoniana</i> Expand the Procyanidin Chemical Space and Exhibit Dental Bioactivity Open
Investigation of a pine bark extract for bioactive proanthocyanidin oligomers resulted in the isolation of structurally related dimeric seco B-type procyanidin derivatives, 1-5. This includes scalemic mixtures of gambiriin A1 (1a) and A2 (…
View article: New Rufomycins from <i>Streptomyces atratus</i> MJM3502 Expand Anti-<i>Mycobacterium tuberculosis</i> Structure–Activity Relationships
New Rufomycins from <i>Streptomyces atratus</i> MJM3502 Expand Anti-<i>Mycobacterium tuberculosis</i> Structure–Activity Relationships Open
Four new rufomycins, compounds 1-4, named rufomycins 56, 57, 58, and 61, respectively, exhibiting new skeletal features, were obtained from Streptomyces atratus strain MJM3502 and were fully characterized. Compounds 1 and 2 possess a 4-imi…
View article: B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (<i>Theobroma cacao</i>)
B-type Proanthocyanidins with Dentin Biomodification Activity from Cocoa (<i>Theobroma cacao</i>) Open
To enable translational studies, a scalable preparative isolation scheme was developed for underivatized cocoa (Theobroma cacao) proanthocyanidins (PACs), affording six all-B-type oligomeric PACs, including a new tetramer 4. Their structur…