Suhas T. Mhaske
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View article: Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation
Priming of mouse pre-osteoblasts with Interleukin-3 attenuates TNF-α-induced-inhibition of osteoblast differentiation Open
Priming mouse pre-osteoblasts with IL- 3 prevents TNF-α-induced of osteoblast differentiation in vitro, and, thus, could be a novel candidate in the treatment of inflammatory bone loss disorders.
View article: Care, management, and use of ferrets in biomedical research
Care, management, and use of ferrets in biomedical research Open
View article: Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation
Plumbagin modulates RANKL-induced osteoclast and osteoblast differentiation Open
Background: Bone remodeling is a balanced, dynamic function of two counteractive processes: osteoblasts-mediated bone formation and osteoclasts-dependent bone resorption. An imbalance between these two processes causes bone diseases. Herei…
View article: SARS-CoV-2 breakthrough infections during the second wave of COVID-19 at Pune, India
SARS-CoV-2 breakthrough infections during the second wave of COVID-19 at Pune, India Open
Breakthrough infections following SARS-CoV-2 vaccination remain the global concern. The current study was conducted during the second wave of COVID-19 (1st March−7th July 2021) in Pune, India, at two tertiary care hospitals. Of the 6,159 p…
View article: Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age
Human gingival mesenchymal stem cells retain their growth and immunomodulatory characteristics independent of donor age Open
Aging has been reported to deteriorate the quantity and quality of mesenchymal stem cells (MSCs), which affect their therapeutic use in regenerative medicine. A dearth of age-related stem cell research further restricts their clinical appl…
View article: Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India
Emergence of two distinct variants of SARS-CoV-2 and an explosive second wave of COVID-19: the experience of a tertiary care hospital in Pune, India Open
View article: Emergence of Two Distinct Variants of SARS-CoV-2 and Explosive Second Wave of COVID-19: An Experience From A Tertiary Care Hospital, Pune, India
Emergence of Two Distinct Variants of SARS-CoV-2 and Explosive Second Wave of COVID-19: An Experience From A Tertiary Care Hospital, Pune, India Open
The emergence of novel variants of SARS-CoV-2 in several countries has been associated with the increased transmission/ reduced neutralization potential of antibodies against the Wuhan virus (wild type). Currently, India is recovering from…
View article: Perinatal transmission of SARS-CoV-2 and transfer of maternal IgG/neutralizing anti-SARS-CoV-2 antibodies from mothers with asymptomatic infection during pregnancy
Perinatal transmission of SARS-CoV-2 and transfer of maternal IgG/neutralizing anti-SARS-CoV-2 antibodies from mothers with asymptomatic infection during pregnancy Open
View article: Isolation and genetic characterization of SARS-CoV-2 from Indian patients in a single family without H/O travel abroad
Isolation and genetic characterization of SARS-CoV-2 from Indian patients in a single family without H/O travel abroad Open
View article: Bone Tumors: Types and Treatments
Bone Tumors: Types and Treatments Open
The tumors associated with bone are mostly of mesenchymal origin and contribute to approximately 1% of all the known tumors. These could be primary/benign tumors (that originate in the bone), secondary tumors (that originate in some other …
View article: IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice
IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice Open
Bone remodeling comprises balanced activities between osteoclasts and osteoblasts, which is regulated by various factors, including hormones and cytokines. We previously reported that IL-3 inhibits osteoclast differentiation and pathologic…
View article: Interleukin-3 enhances the migration of human mesenchymal stem cells by regulating expression of CXCR4
Interleukin-3 enhances the migration of human mesenchymal stem cells by regulating expression of CXCR4 Open
View article: IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice Open
Osteoarthritis (OA) is a chronic disease of articular joints that leads to degeneration of both cartilage and subchondral bone. These degenerative changes are further aggravated by proinflammatory cytokines including IL-1β and TNF-α. Previ…