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View article: Cap Polyposis Syndrome Imitating Inflammatory Bowel Disease with Polyps Extending to the Terminal Ileum
Cap Polyposis Syndrome Imitating Inflammatory Bowel Disease with Polyps Extending to the Terminal Ileum Open
Introduction: Cap polyposis syndrome is a rare subtype of mucosal prolapse disease characterized by erythematous, inflammatory colonic polyps covered by a cap of fibrinopurulent mucous. Although a benign condition, patients may present wit…
View article: Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer
Tumor-infiltrating mast cells confer resistance to immunotherapy in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) exhibits an immunosuppressive tumor microenvironment (TME) contributing to its therapeutic resistance. Following our previous studies, we report that mast cells infiltrating the PDAC TME foster this …
View article: Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up
Antibody-Mediated Rejection in Liver Transplantation: Immuno-Pathological Characteristics and Long-Term Follow-Up Open
The diagnosis of liver antibody-mediated rejection (AMR) is challenging and likely under-recognized. The association of AMR with donor-specific antibodies (DSA), and its clinical course in relation to pathologic findings and treatment are …
View article: Surgical Management of a Large Well-Differentiated Liposarcoma in the Supraclavicular Fossa: A Case Report
Surgical Management of a Large Well-Differentiated Liposarcoma in the Supraclavicular Fossa: A Case Report Open
Background: Liposarcomas originating in the supraclavicular fossa are exceptionally rare, with only a few documented cases in the medical literature. Methods: We present a unique case involving a remarkably large indolent, atypical lipomat…
View article: Odontogenic Sarcomas of the Mandible
Odontogenic Sarcomas of the Mandible Open
Odontogenic sarcomas are exceedingly rare and account for less than 5% of all Maxillofacial Sarcomas. It usually affects the younger population. The posterior mandible is the most commonly affected site. Radiographically, it appears as a l…
View article: A Case of Esophageal Adenocarcinoma Metastatic to the Breast
A Case of Esophageal Adenocarcinoma Metastatic to the Breast Open
Metastatic carcinoma infiltrating the breast from extramammary malignancies is an infrequent occurrence. Extramammary carcinomas that may be metastatic to the breast include gastrointestinal cancers, ovarian cancer, and lung cancer, among …
View article: Isolated cryptococcal osteomyelitis in the setting of immune reconstitution inflammatory syndrome
Isolated cryptococcal osteomyelitis in the setting of immune reconstitution inflammatory syndrome Open
Cryptococcal infections, though rare, must be considered in all immunocompromised patients. Patients with HIV/AIDS on antiretrovirals may have a treatment course complicated by immune reconstitution inflammatory syndrome. Here we present a…
View article: Diverse Clinical Manifestations and Challenges of Mucormycosis: Insights From Serial Cases
Diverse Clinical Manifestations and Challenges of Mucormycosis: Insights From Serial Cases Open
Mucormycosis is a severe and potentially life-threatening infection caused by a group of fungi classified as mucormycetes within the scientific order Mucorales. These infections are characterized by rapid and invasive fungal growth, presen…
View article: Schistosomiasis: An Unexpected Cause of Gastrointestinal Bleeding Revealed by Endoscopic Biopsy
Schistosomiasis: An Unexpected Cause of Gastrointestinal Bleeding Revealed by Endoscopic Biopsy Open
CASE REPORT A 28-year-old man from Equatorial Guinea presented with debilitating fatigue, persistent shortness of breath for the past year, and notable episodes of hematochezia and melena for the past week. Laboratory workup indicated the …
View article: Laryngeal Sarcomatoid Carcinoma With Rhabdomyoblastic Differentiation: A Potential Pitfall for Misdiagnosis As Rhabdomyosarcoma
Laryngeal Sarcomatoid Carcinoma With Rhabdomyoblastic Differentiation: A Potential Pitfall for Misdiagnosis As Rhabdomyosarcoma Open
Sarcomatoid carcinoma (SC) of the larynx is an uncommon subtype of squamous cell carcinoma which shows both squamous carcinoma and a sarcomatous component, including heterologous elements. The presence of rhabdomyosarcomatous elements in t…
View article: Amyloid goiter secondary to familial Mediterranean fever with E148Q mutation: A unique case
Amyloid goiter secondary to familial Mediterranean fever with E148Q mutation: A unique case Open
Dear Editor, Goiter is defined as the enlargement of the thyroid gland. It is currently divided into diffuse and nodular and subdivided into toxic (associated with hyperthyroidism) or nontoxic (associated with normal thyroid stimulating ho…
View article: Supplemental Figure (1) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure (1) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Comparison of metabolite levels in CBS2 vs. vector control NCM356 cells.
View article: Supplemental Figure (3) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure (3) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Effect of buthionine-sulfoximine (BSO) on growth of CBS2 and vector control cells.
View article: Data from Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging
Data from Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging Open
Early neoplastic features in oral epithelial dysplasia are first evident at the basal epithelium positioned at the epithelial–connective tissue interface (ECTI), separating the basal epithelium from the underlying lamina propria. The ECTI …
View article: Supplemental Figure 1: Spatial variation and reduction of collagen density in OED. from Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging
Supplemental Figure 1: Spatial variation and reduction of collagen density in OED. from Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging Open
a) Spatial variation of collagen density is shown by reduced SHG signal in the compromised LP beneath neoplastic foci relative to neighboring LP outside the foci. b) Average collagen density in control, inflammation and OED. "*" and "**" r…
View article: Supplemental Figure (3) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure (3) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Effect of buthionine-sulfoximine (BSO) on growth of CBS2 and vector control cells.
View article: Supplemental Table (2) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Table (2) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Gene Set Enrichment Analysis for NCM356 vector vs. CBS cells.
View article: Supplemental Figure 1: Spatial variation and reduction of collagen density in OED. from Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging
Supplemental Figure 1: Spatial variation and reduction of collagen density in OED. from Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging Open
a) Spatial variation of collagen density is shown by reduced SHG signal in the compromised LP beneath neoplastic foci relative to neighboring LP outside the foci. b) Average collagen density in control, inflammation and OED. "*" and "**" r…
View article: Supplemental Table (2) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Table (2) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Gene Set Enrichment Analysis for NCM356 vector vs. CBS cells.
View article: Supplemental Figure (4) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure (4) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
CBS overexpression and an H2S donor (GYY4137) enhanced NCM356 cell growth in soft agar.
View article: Supplemental Table (1) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Table (1) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Single-nucleotide polymorphism analysis for NCM356 cells.
View article: Data from Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer
Data from Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer Open
Purpose: The mammalian target of rapamycin (mTOR) kinase acts downstream of phosphoinositide 3-kinase/Akt to regulate cellular growth, metabolism, and cytoskeleton. Because ∼60% of sporadic colorectal cancers (CRC) exhibit high levels of a…
View article: Supplemental Figure (1) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure (1) from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Comparison of metabolite levels in CBS2 vs. vector control NCM356 cells.
View article: Data from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Data from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mech…
View article: Supplementary Data from Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer
Supplementary Data from Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer Open
Supplementary Data from Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer
View article: Supplemental Figure Legends from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure Legends from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Additional description of metabolic effects and effects of hydrogen sulfide on CBS overexpression in NCM356 cells.
View article: Data from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Data from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mech…
View article: Supplemental Figure Legends from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis
Supplemental Figure Legends from Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis Open
Additional description of metabolic effects and effects of hydrogen sulfide on CBS overexpression in NCM356 cells.