Shuo Xu
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View article: Functional analysis of PHLDA2 in ovarian cancer: Effects on tumor cell behavior and autophagy
Functional analysis of PHLDA2 in ovarian cancer: Effects on tumor cell behavior and autophagy Open
These findings reveal that knockdown of PHLDA2 suppresses OC cell proliferation, migration and invasion, while promoting autophagy and inactivating the PI3K/AKT/mTOR pathway, suggesting that PHLDA2 may contribute to OC progression.
View article: Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets
Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets Open
X‐linked hypophosphatemic rickets (XLHR) is a rare X‐linked dominant skeletal dysplasia caused by phosphate regulating endopeptidase homolog X‐linked (PHEX) gene mutation. Until now, the pathogenic role of PHEX has not been fully determine…
View article: Preexisting ulcerative colitis increases the risk of immune-related colitis and predicts divergent survival outcomes in gastrointestinal cancer patients treated with immune checkpoint inhibitors
Preexisting ulcerative colitis increases the risk of immune-related colitis and predicts divergent survival outcomes in gastrointestinal cancer patients treated with immune checkpoint inhibitors Open
Background The risk of immune-related colitis (IRC) and efficacy of immune checkpoint inhibitors (ICIs) in patients with gastrointestinal cancers and preexisting ulcerative colitis (UC) has not been well described. Patients and methods We …
View article: Bridging Vision and Language: Optimal Transport-Driven Radiology Report Generation via LLMs
Bridging Vision and Language: Optimal Transport-Driven Radiology Report Generation via LLMs Open
Radiology report generation represents a significant application within medical AI, and has achieved impressive results. Concurrently, large language models (LLMs) have demonstrated remarkable performance across various domains. However, e…
View article: Single-cell RNA sequencing revealed cell landscape of tongue dorsal mucosa in rats with gastric intestinal metaplasia
Single-cell RNA sequencing revealed cell landscape of tongue dorsal mucosa in rats with gastric intestinal metaplasia Open
The formation of tongue coating is closely related with the differentiation of the lingual dorsal mucosa, and a great deal of evidence shows that the variation of tongue coating reflects the pathological and physiological state of the gast…
View article: Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells Open
Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART im…
View article: <scp>CCN1</scp> Promotes Mesenchymal Phenotype Transition Through Activating <scp>NF</scp>‐<scp>κB</scp> Signaling Pathway Regulated by <scp>S100A8</scp> in Glioma Stem Cells
<span>CCN1</span> Promotes Mesenchymal Phenotype Transition Through Activating <span>NF</span>‐<span>κB</span> Signaling Pathway Regulated by <span>S100A8</span> in Glioma Stem Cells Open
Background The presence of glioma stem cells (GSCs) and the occurrence of mesenchymal phenotype transition contribute to the miserable prognosis of glioblastoma (GBM). Cellular communication network factor 1 (CCN1) is upregulated within va…
View article: <scp>SAP</scp> deletion promotes malignant insulinoma progression by inducing <scp>CXCL12</scp> secretion from <scp>CAFs</scp> via the <scp>CXCR4</scp>/p38/<scp>ERK</scp> signalling pathway
<span>SAP</span> deletion promotes malignant insulinoma progression by inducing <span>CXCL12</span> secretion from <span>CAFs</span> via the <span>CXCR4</span>/p38/<span>ERK</span> signalling pathway Open
Malignant insulinoma is an extremely rare type of functioning pancreatic neuroendocrine tumour with a high degree of malignancy and a high incidence of metastasis. However, it is still unclear how malignant insulinomas develop and metastas…
View article: Characterization of Novel <i>PHEX</i> Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation
Characterization of Novel <i>PHEX</i> Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation Open
Background X-linked hypophosphatemia (XLHR) is the most common genetic form of hypophosphatemic rickets (HR), which is caused by phosphate regulating endopeptidase homolog X-linked (PHEX) gene mutation. At present, the genotype–phenotype r…
View article: Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma
Immune Checkpoint Inhibitors for Child-Pugh Class B Advanced Hepatocellular Carcinoma Open
Importance Immune checkpoint inhibitors (ICIs) are increasingly used in patients with advanced hepatocellular carcinoma (HCC). However, data on ICI therapy in patients with advanced HCC and impaired liver function are scarce. Objective To …
View article: Correlation between immune‑related adverse events and treatment efficacy of anti‑PD1 immunotherapy in patients with esophageal squamous cell carcinoma
Correlation between immune‑related adverse events and treatment efficacy of anti‑PD1 immunotherapy in patients with esophageal squamous cell carcinoma Open
Immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) are associated with improved treatment efficacy in certain types of cancer. In the present study, we assessed the association between irAEs and ICI efficac…
View article: Correlation Between Immune-Related Adverse Events and Prognosis in Hepatocellular Carcinoma Patients Treated With Immune Checkpoint Inhibitors
Correlation Between Immune-Related Adverse Events and Prognosis in Hepatocellular Carcinoma Patients Treated With Immune Checkpoint Inhibitors Open
Background Immune-related adverse events (irAEs) caused by immune checkpoint inhibitors (ICIs) were associated with clinical benefit in cancer patients of melanoma, a lung cancer. In the present study, we investigated the correlation betwe…
View article: A Five Immune-Related lncRNA Signature as a Prognostic Target for Glioblastoma
A Five Immune-Related lncRNA Signature as a Prognostic Target for Glioblastoma Open
Background: A variety of regulatory approaches including immune modulation have been explored as approaches to either eradicate antitumor response or induce suppressive mechanism in the glioblastoma microenvironment. Thus, the study of imm…
View article: 3:36 PM Abstract No. 368 Prediction for the recurrence of hemoptysis patients treated with bronchial artery embolization: a novel nomogram and artificial neural network
3:36 PM Abstract No. 368 Prediction for the recurrence of hemoptysis patients treated with bronchial artery embolization: a novel nomogram and artificial neural network Open
View article: miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12
miR‑767‑5p inhibits glioma proliferation and metastasis by targeting SUZ12 Open
A growing body of evidence implicates aberrant expression of microRNAs (miRNAs) and dysregulation of mRNA translation in the development and growth of cancer cells. However, little is known about the mechanisms of action of miRNAs in gliom…
View article: Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis
Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis Open
Glioblastoma (GBM) is a highly malignant brain tumor characterized by invasion tendency. Macrophage infiltration is associated with GBM invasion, but the mechanisms remain unclear. Hypoxia is an outstanding characteristic of GBM tissue. Hy…
View article: Improving the Grading Accuracy of Astrocytic Neoplasms Noninvasively by Combining Timing Information with Cerebral Blood Flow: A Multi-TI Arterial Spin-Labeling MR Imaging Study
Improving the Grading Accuracy of Astrocytic Neoplasms Noninvasively by Combining Timing Information with Cerebral Blood Flow: A Multi-TI Arterial Spin-Labeling MR Imaging Study Open
Multi-TI arterial spin-labeling imaging can evaluate perfusion dynamics by combining normalized bolus arrival time and normalized CBF values derived from multiple TIs. It is superior to single-TI arterial spin-labeling imaging and conventi…
View article: MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints
MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints Open
MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints which may have rapid translational potential as a novel immunotherapeutic agent.