Sujan Dhar
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View article: Does neoadjuvant chemotherapy bias the transcriptomic profile of platinum-sensitive advanced high grade serous ovarian cancer patients towards a resistant phenotype? Findings from a gene expression meta-analysis
Does neoadjuvant chemotherapy bias the transcriptomic profile of platinum-sensitive advanced high grade serous ovarian cancer patients towards a resistant phenotype? Findings from a gene expression meta-analysis Open
Background Chemoresistance is the key determinant of long-term survival in advanced high-grade serous ovarian cancer (HGSOC). The molecular mechanisms underlying chemoresistance in clinical populations are not clearly known. The study aime…
View article: The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties
The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties Open
Spermatozoa reach the fallopian tube during ovulation by traveling through the female reproductive tract mucus. This non‐Newtonian viscoelastic medium facilitates spermatozoon movement to accomplish fertilization or, in some cases, blocks …
View article: Novel CAF-identifiers via transcriptomic and protein level analysis in HNSC patients
Novel CAF-identifiers via transcriptomic and protein level analysis in HNSC patients Open
Cancer-associated fibroblasts (CAFs), a prominent component of the tumor microenvironment, play an important role in tumor development, invasion, and drug resistance. The expression of distinct “CAF-markers” which separates CAFs from norma…
View article: PHASE‐2 FIRST‐IN‐INDIA INDUSTRY STUDY OF VARNIMCABTAGENE AUTOLEUCEL (IMN‐003A) IN RELAPSED REFRACTORY B CELL MALIGNANCIES: IMAGINE STUDY B‐NHL SUBANALYSIS
PHASE‐2 FIRST‐IN‐INDIA INDUSTRY STUDY OF VARNIMCABTAGENE AUTOLEUCEL (IMN‐003A) IN RELAPSED REFRACTORY B CELL MALIGNANCIES: IMAGINE STUDY B‐NHL SUBANALYSIS Open
Introduction: Varnimcabtagene autoleucel (IMN-003A) is an autologous CD19 directed CAR-T with 4-1BB co-stim domain and A3B1 binder, a non-FMC63 murine scFv, manufactured in India for phase 2 study in patients (pts) with relapsed / refracto…
View article: Estimation of ALU Repetitive Elements in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer
Estimation of ALU Repetitive Elements in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer Open
Background: Liquid biopsy is widely recognized as an efficient diagnostic method in oncology for disease detection and monitoring. Though the examination of circulating tumor cells (CTC) is mostly implemented for the assessment of genomic …
View article: <i>In vitro</i>and<i>in vivo</i>evidences propound therapeutic potential of Lipocalin 2 in cervical carcinoma
<i>In vitro</i>and<i>in vivo</i>evidences propound therapeutic potential of Lipocalin 2 in cervical carcinoma Open
Cervical cancer (CC), the second most common in developing countries and the third most common in developed nations, is the fourth most common type of cancer in women overall. The HPV16 high-risk genotype of the virus, which is responsible…
View article: Novel CAF-identifiers via transcriptomic analysis in oral cancer patients
Novel CAF-identifiers via transcriptomic analysis in oral cancer patients Open
Background Cancer-associated fibroblasts (CAFs), a prominent component of the tumor microenvironment, plays an important role in tumor development, invasion, and drug resistance. The expression of distinct “CAF markers,” which separates CA…
View article: Estimation of ALU Repetitive Element in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer
Estimation of ALU Repetitive Element in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer Open
Background: Liquid biopsy is widely recognised as an efficient diagnostic method in oncology for disease detection and monitoring. Though examination of circulating tumor cell (CTC) is mostly implemented for assessment of genomic aberratio…
View article: Recombinant Human ACE2-Fc : A promising therapy for SARS-CoV2 infection
Recombinant Human ACE2-Fc : A promising therapy for SARS-CoV2 infection Open
SARS-CoV2 entry is mediated by binding of viral spike-protein(S) to the transmembrane Angiotensin-Converting Enzyme-2 (ACE2) of the host cell. Thus, to prevent transmission of disease, strategies to abrogate the interaction are important. …
View article: ACE2Fc: A Promising Therapy for SARS-Cov2 Infection
ACE2Fc: A Promising Therapy for SARS-Cov2 Infection Open
SARS-CoV2 entry is mediated by binding of viral spike-protein (S) to the transmembrane Angiotensin-Converting Enzyme-2 (ACE2) of the host cell. Thus, to prevent transmission of disease, strategies to abrogate the interaction are important.…
View article: Reference Genes for gene expression analysis in Head and Neck Squamous Cell Carcinoma: a Data Science Driven Approach
Reference Genes for gene expression analysis in Head and Neck Squamous Cell Carcinoma: a Data Science Driven Approach Open
Quantitative real time PCR (qPCR) remains by far the most cost-effective, fast yet sensitive technique to check the gene expression levels in various systems. Traditionally used reference genes over the years were found to be regulated hea…
View article: Anti-diabetic effects of<i>Holarrhena antidysentrica</i>extracts: Results from a Longitudinal Meta-analysis
Anti-diabetic effects of<i>Holarrhena antidysentrica</i>extracts: Results from a Longitudinal Meta-analysis Open
Background Holarrhena antidysenterica (HA), a twining shrub belonging to the Apocynaceae family is found in tropical regions of Africa and over a large part of Asia including India, Philippines and Malayan Peninsula. In Indian traditional …
View article: IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression
IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression Open
Aims SARS-CoV-2, an infectious agent behind the ongoing COVID-19 pandemic, induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in infected individuals which contribute towards the underlying disease pat…
View article: Relative quantification of BCL2 mRNA for diagnostic usage needs stable uncontrolled genes as reference
Relative quantification of BCL2 mRNA for diagnostic usage needs stable uncontrolled genes as reference Open
Dysregulation of BCL2 is a pathophysiology observed in haematological malignancies. For implementation of available treatment-options it is preferred to know the relative quantification of BCL2 mRNA with appropriate reference genes. For th…
View article: Genome Wide Search to Identify Reference Genes candidates for Gene Expression Analysis in Gossypium hirsutum
Genome Wide Search to Identify Reference Genes candidates for Gene Expression Analysis in Gossypium hirsutum Open
Background: Cotton is one of the most important commercial crops as the source of natural fiber, oil and fodder. To protect it from harmful pest populations number of newer transgenic lines have been developed. For quick expression checks …
View article: PDL-1 expression in oral squamous cell carcinoma and implications for treatment.
PDL-1 expression in oral squamous cell carcinoma and implications for treatment. Open
82 Background: PDL-1 expression has been shown in multiple tumours to be a key factor in treatment response and immunogenicity. In oral squamous cell carcinoma (OSCC), its role is controversial; the expression levels, prognostic significan…
View article: Genome wide search to identify reference genes candidates for gene expression analysis in Gossypium hirsutum
Genome wide search to identify reference genes candidates for gene expression analysis in Gossypium hirsutum Open
Background Cotton is one of the most important commercial crops as the source of natural fiber, oil and fodder. To protect it from harmful pest populations number of newer transgenic lines have been developed. For quick expression checks i…
View article: CFD Modelling of Coupled Heat Transfer between Solid and Fluid in a Twin Screw Compressor
CFD Modelling of Coupled Heat Transfer between Solid and Fluid in a Twin Screw Compressor Open
Temperature variation in a compressor is very critical for compression performance and efficiency. To accurately predict the thermal dynamic behaviour of a compressor, heat transfer between metal components and the working fluid needs to b…
View article: Genome Wide Search to Identify Reference Genes candidates for Gene Expression Analysis in Gossypium hirsutum
Genome Wide Search to Identify Reference Genes candidates for Gene Expression Analysis in Gossypium hirsutum Open
Background: With the advent of newer breeds and transgenic varieties of commercial crops, qPCR (quantitative polymerase chain reaction) experiments have become extremely popular for quick expression checks. Selection of appropriate referen…
View article: Genome Based Search for Reference Genes for Gene Expression Analysis in Oral Cancer: a Data Science Driven Approach
Genome Based Search for Reference Genes for Gene Expression Analysis in Oral Cancer: a Data Science Driven Approach Open
Background Quantitative real time PCR (qPCR) remains by far the most cost-effective, fast yet sensitive technique to check the gene expression levels in various systems. The traditionally used reference genes over the years were found to b…
View article: Additional file 5: of Genome wide search to identify reference genes candidates for gene expression analysis in Gossypium hirsutum
Additional file 5: of Genome wide search to identify reference genes candidates for gene expression analysis in Gossypium hirsutum Open
Stability analysis of the candidate reference genes using different algorithms. (XLSX 69 kb)
View article: Additional file 3: of Genome wide search to identify reference genes candidates for gene expression analysis in Gossypium hirsutum
Additional file 3: of Genome wide search to identify reference genes candidates for gene expression analysis in Gossypium hirsutum Open
List of Genes selected in the study. The list of genes in cluster 2 (sheet 1) and cluster 1(sheet 2) top 100 Genes in the selected cluster 1, sorted in ascending order based on the calculated Euclidean distance (sheet 3) and the selected 1…
View article: A 3-D Transient CFD Model of a Reciprocating Piston Compressor with Dynamic Port Flip Valves
A 3-D Transient CFD Model of a Reciprocating Piston Compressor with Dynamic Port Flip Valves Open
In this paper a full transient 3-D CFD model of a complete single piston compressor system along with dynamic inlet and outlet port flip valves is presented. The model includes the motion of the cam driven piston, and also predicts the mot…