Sujata Biswas
YOU?
Author Swipe
View article: Comparison between germline and somatic loss-of-function <i>RNF43</i> mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis
Comparison between germline and somatic loss-of-function <i>RNF43</i> mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis Open
Background Germline RNF43 mutations cause a dominantly inherited syndrome of colorectal cancer (CRC) and serrated polyps. However, these data originate from highly selected families. Objective We assessed germline RNF43 variants in patient…
View article: Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA Open
Platelets are anucleate blood cells vital for hemostasis and immunity. During cell death and aberrant mitosis, nucleated cells release DNA, resulting in “cell-free” DNA in plasma (cfDNA). An excess of cfDNA is deleterious. Given their abil…
View article: Development and validation of a diagnostic prediction model for pancreatic ductal adenocarcinoma: VAPOR 1, protocol for a prospective multicentre case–control study
Development and validation of a diagnostic prediction model for pancreatic ductal adenocarcinoma: VAPOR 1, protocol for a prospective multicentre case–control study Open
Introduction Pancreatic ductal adenocarcinoma (PDAC) continues to have extremely poor patient outcomes, unlike other cancer types which have seen significant improvements in their treatments and survival. A major contributing factor is tha…
View article: Supplementary Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Supplementary Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis Open
Supplementary Table 1. Differentially expressed genes from colonic crypt tops vs. bottoms of normal individuals (adjusted p<0.05). Supplementary Table 2. SGK1 expression of CRC cell lines from Broad Institute, The Cancer Cell Line Encyclop…
View article: Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis Open
Purpose:The molecular events that determine intestinal cell differentiation are poorly understood and it is unclear whether it is primarily a passive event or an active process. It is clinically important to gain a greater understanding of…
View article: Supplementary Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Supplementary Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis Open
Supplementary Table 1. Differentially expressed genes from colonic crypt tops vs. bottoms of normal individuals (adjusted p<0.05). Supplementary Table 2. SGK1 expression of CRC cell lines from Broad Institute, The Cancer Cell Line Encyclop…
View article: Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Data from Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis Open
Purpose:The molecular events that determine intestinal cell differentiation are poorly understood and it is unclear whether it is primarily a passive event or an active process. It is clinically important to gain a greater understanding of…
View article: Drug-induced liver injury: a comprehensive review
Drug-induced liver injury: a comprehensive review Open
Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. Although it has a low incidence amongst the general population, DILI accounts for most cases of acute liver failure with a fat…
View article: Germline variant testing in serrated polyposis syndrome
Germline variant testing in serrated polyposis syndrome Open
Background and Aim Serrated polyposis syndrome (SPS) is now known to be the commonest polyposis syndrome. Previous analyses for germline variants have shown no consistent positive findings. To exclude other polyposis syndromes, 2019 Britis…
View article: PTU-9 Post-colonoscopy colorectal cancer: A 5-year analysis and measures implemented at a district general hospital
PTU-9 Post-colonoscopy colorectal cancer: A 5-year analysis and measures implemented at a district general hospital Open
Introduction Post-colonoscopy colorectal cancer (PCCRC) is the diagnosis of cancer up to 3 years after a colonoscopy at which no cancer was found. It is a measure of endoscopy quality assurance and PCCRC rates are expected as part of both …
View article: BMP pathway antagonism by<i>Grem1</i>regulates epithelial cell fate in intestinal regeneration
BMP pathway antagonism by<i>Grem1</i>regulates epithelial cell fate in intestinal regeneration Open
In the intestine, the homeostatic effect of Bone Morphogenetic Protein (BMP) on cell fate has predominantly been inferred through pathway inactivation. Here, we assessed the impact of autocrine Bmp4 expression on secretory cell fate. Ligan…
View article: O57 The value of germline mutation testing in serrated polyposis syndrome
O57 The value of germline mutation testing in serrated polyposis syndrome Open
Introduction Serrated Polyposis Syndrome (SPS) is now known to be the commonest polyposis syndrome. Previous analyses for germline mutations have shown no consistent positive findings1. To exclude other polyposis syndromes, new 2019 BSG gu…
View article: Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis Open
Purpose: The molecular events that determine intestinal cell differentiation are poorly understood and it is unclear whether it is primarily a passive event or an active process. It is clinically important to gain a greater understanding o…
View article: Evolutionary history of human colitis-associated colorectal cancer
Evolutionary history of human colitis-associated colorectal cancer Open
Objective IBD confers an increased lifetime risk of developing colorectal cancer (CRC), and colitis-associated CRC (CA-CRC) is molecularly distinct from sporadic CRC (S-CRC). Here we have dissected the evolutionary history of CA-CRC using …
View article: Control of intestinal progenitor cell fate by the microenvironment
Control of intestinal progenitor cell fate by the microenvironment Open
The conventional model of intestinal epithelial architecture describes a unidirectional tissue organisational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they prog…
View article: The metaplastic mosaic of Barrett’s oesophagus
The metaplastic mosaic of Barrett’s oesophagus Open
Barrett’s oesophagus surveillance biopsies represent a significant share of the daily workload for a busy histopathology department. Given the emphasis on endoscopic detection and dysplasia grading, it is easy to forget that the benefits o…
View article: Trends in UK endoscopy training in the BSG trainees’ national survey and strategic planning for the future
Trends in UK endoscopy training in the BSG trainees’ national survey and strategic planning for the future Open
Background Improvements in the structure of endoscopy training programmes resulting in certification from the Joint Advisory Group in Gastrointestinal Endoscopy have been acknowledged to improve training experience and contribute to enhanc…
View article: Placebo response and remission rates in randomised trials of induction and maintenance therapy for ulcerative colitis
Placebo response and remission rates in randomised trials of induction and maintenance therapy for ulcerative colitis Open
Placebo response and remission rates vary according to endoscopic disease severity and rectal bleeding score at trial entry, class of agent, disease duration, and the time point at which the primary outcome was measured. These observations…
View article: Bone morphogenetic protein and Notch signalling crosstalk in poor‐prognosis, mesenchymal‐subtype colorectal cancer
Bone morphogenetic protein and Notch signalling crosstalk in poor‐prognosis, mesenchymal‐subtype colorectal cancer Open
The functional role of bone morphogenetic protein ( BMP ) signalling in colorectal cancer ( CRC ) is poorly defined, with contradictory results in cancer cell line models reflecting the inherent difficulties of assessing a signalling pathw…
View article: Systematic review with meta‐analysis: placebo rates in induction and maintenance trials of Crohn's disease
Systematic review with meta‐analysis: placebo rates in induction and maintenance trials of Crohn's disease Open
Summary Background Minimising placebo response is essential for drug development. Aim To conduct a meta‐analysis to determine placebo response and remission rates in trials and identify the factors affecting these rates. Methods MEDLINE , …
View article: Systematic Review and Meta-analysis: Placebo Rates in Induction and Maintenance Trials of Ulcerative Colitis
Systematic Review and Meta-analysis: Placebo Rates in Induction and Maintenance Trials of Ulcerative Colitis Open
Objective assessment of greater disease activity at trial entry by endoscopy lowered placebo rates, whereas increasing trial duration and more interactions with healthcare providers increased placebo rates. These findings have important im…