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View article: Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα
Hemin regulates platelet clearance in hemolytic disease by binding to GPIbα Open
Hemolysis is associated with thrombosis and vascular dysfunction, which are the pathological components of many diseases. Hemolytic products, including hemoglobin and hemin, activate platelets (PLT). Despite its activation, the effect of h…
View article: Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets
Current Advances in Nanomaterials Affecting Functions and Morphology of Platelets Open
Nanomaterials have been extensively used in the biomedical field due to their unique physical and chemical properties. They promise wide applications in the diagnosis, prevention, and treatment of diseases. Nanodrugs are generally transpor…
View article: Assaying Storage Lesion of Irradiated Red Blood Cells by Deep Learning with Attention Mechanism
Assaying Storage Lesion of Irradiated Red Blood Cells by Deep Learning with Attention Mechanism Open
View article: Laponite Lights Calcium Flickers by Reprogramming Lysosomes to Steer DC Migration for An Effective Antiviral CD8<sup>+</sup> T‐Cell Response
Laponite Lights Calcium Flickers by Reprogramming Lysosomes to Steer DC Migration for An Effective Antiviral CD8<sup>+</sup> T‐Cell Response Open
Immunotherapy using dendritic cell (DC)‐based vaccination is an established approach for treating cancer and infectious diseases; however, its efficacy is limited. Therefore, targeting the restricted migratory capacity of the DCs may enhan…
View article: Stored whole blood transfusion initiates serum amyloid A activation monitored by real-time dynamic imaging.
Stored whole blood transfusion initiates serum amyloid A activation monitored by real-time dynamic imaging. Open
Storage lesions will also occur during the storage of whole blood, which is related to the change in RBCs with prolonged storage. The side effect induced by systemic inflammation and acute-phase reaction should be considered before resusci…
View article: A novel plasma membrane-phillic graphene oxide nanocarrier for neuropeptide delivery to generate tolerogenic dendritic cells in GVHD Immunotherapy
A novel plasma membrane-phillic graphene oxide nanocarrier for neuropeptide delivery to generate tolerogenic dendritic cells in GVHD Immunotherapy Open
The prevention and the treatment of graft-versus-host disease (GVHD) remains a barrier to allogeneic hematopoietic stem cell transplantation (allo-HSCT). Tolerogenic dendritic cells (TDCs) have become a hotspot in GVHD prevention despite t…
View article: Large‐Sized Graphene Oxide Nanosheets Increase DC–T‐Cell Synaptic Contact and the Efficacy of DC Vaccines against SARS‐CoV‐2
Large‐Sized Graphene Oxide Nanosheets Increase DC–T‐Cell Synaptic Contact and the Efficacy of DC Vaccines against SARS‐CoV‐2 Open
Dendritic cell (DC) vaccines are used for cancer and infectious diseases, albeit with limited efficacy. Modulating the formation of DC–T‐cell synapses may greatly increase their efficacy. The effects of graphene oxide (GO) nanosheets on DC…
View article: Dimethyl Sulfoxide-Free Cryopreservation of Human Umbilical Cord Mesenchymal Stem Cells Based on Zwitterionic Betaine and Electroporation
Dimethyl Sulfoxide-Free Cryopreservation of Human Umbilical Cord Mesenchymal Stem Cells Based on Zwitterionic Betaine and Electroporation Open
The effective cryopreservation of mesenchymal stem cells (MSCs) is indispensable to the operation of basic research and clinical transplantation. The prevalent protocols for MSC cryopreservation utilize dimethyl sulfoxide (DMSO), which is …
View article: Stored Whole Blood Transfusion Initiate Serum Amyloid A Activation Monitored by Real-Time Dynamic Imaging
Stored Whole Blood Transfusion Initiate Serum Amyloid A Activation Monitored by Real-Time Dynamic Imaging Open
BACKGROUND: Transfusion of stored whole blood (SWB) is increasingly routine practice to resuscitate severe traumatic hemorrhage patients in military operations and civilian emergency centers. It has been well established that transfusion o…
View article: <p>Immunostimulatory Potential of MoS<sub>2</sub> Nanosheets: Enhancing Dendritic Cell Maturation, Migration and T Cell Elicitation</p>
Immunostimulatory Potential of MoS<sub>2</sub> Nanosheets: Enhancing Dendritic Cell Maturation, Migration and T Cell Elicitation Open
Few-layered MSNs ranging from 100 to 500 nm in size could play an immunostimulatory role in enhancing DC maturation, migration and T cell elicitation, making them a good candidate for vaccine adjuvants. Investigation of this study will not…
View article: Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells
Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells Open
View article: Additional file 1: of Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells
Additional file 1: of Targeting ectodysplasin promotor by CRISPR/dCas9-effector effectively induces the reprogramming of human bone marrow-derived mesenchymal stem cells into sweat gland-like cells Open
Primer sequence information for RT-qPCR amplification. (XLSX 11 kb)
View article: Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice
Virus-like particle vaccine by intranasal vaccination elicits protective immunity against respiratory syncytial viral infection in mice Open
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory infection in infants and children, but there is still no licensed vaccine available. In this report, we developed virus-like particle (VLP) vaccines based on the Bac…
View article: Protection conferred by virus-like particle vaccines against respiratory syncytial virus infection in mice by intranasal vaccination
Protection conferred by virus-like particle vaccines against respiratory syncytial virus infection in mice by intranasal vaccination Open
Respiratory syncytial virus (RSV) is a major pathogen in infants and the elderly, causing pneumonia and bronchiolitis. Despite decades of research, to date there is still no approved RSV vaccine available. In this study, we developed RSV v…