Sujun Yan
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View article: Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence
Dynamic Rendition of Adipose Genes Under Epigenetic Regulation: Revealing New Mechanisms of Obesity Occurrence Open
Obesity is a chronic metabolic disorder and a growing global public health challenge, affecting hundreds of millions of individuals worldwide. While diet and physical activity are well-established contributors, increasing evidence undersco…
View article: Epitranscriptomic Role of m6A in Obesity-Associated Disorders and Cancer Metabolic Reprogramming
Epitranscriptomic Role of m6A in Obesity-Associated Disorders and Cancer Metabolic Reprogramming Open
The global rise in obesity and its associated metabolic disorders underscores the need for a deeper investigation into their underlying molecular mechanisms. While genetic factors are well-established contributors, recent research has incr…
View article: Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response
Nuclear accumulation of YTHDF1 regulates mRNA splicing in the DNA damage response Open
YTH domain–containing family protein 1 (YTHDF1), a reader of N6-methyladenosine (m 6 A), has been implicated in regulating RNA metabolism in the cytosol. Here, we report a role of YTHDF1 within the nucleus in response to genotoxic stress. …
View article: Transcriptome-wide mapping of N3-methylcytidine modification at single-base resolution
Transcriptome-wide mapping of N3-methylcytidine modification at single-base resolution Open
3-Methylcytidine (m3C), a prevalent modification of transfer RNAs (tRNAs), was recently identified in eukaryotic messenger RNAs (mRNAs). However, its precise distribution and formation mechanisms in mRNAs remain elusive. Here, we develop a…
View article: <strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong>
<strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong> Open
The induction of beige adipocytes in white adipose tissue, also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we report tha…
View article: Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity
Activation of METTL3 Promotes White Adipose Tissue Beiging and Combats Obesity Open
The induction of beige adipocytes in white adipose tissue (WAT), also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we repo…
View article: <strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong>
<strong>Activation of METTL3 promotes white adipose tissue beiging and combats obesity</strong> Open
The induction of beige adipocytes in white adipose tissue, also known as WAT beiging, improves glucose and lipid metabolism. However, the regulation of WAT beiging at the posttranscriptional level remains to be studied. Here, we report tha…
View article: Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice
Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice Open
Obesity, one of the most serious public health issues, is caused by the imbalance of energy intake and energy expenditure. N(6)-methyladenosine (m 6 A) RNA modification has been recently identified as a key regulator of obesity, while the …
View article: Nitrogen-Containing Compounds From Mangrove-Derived Fungus <i>Aspergillus</i> sp. 87
Nitrogen-Containing Compounds From Mangrove-Derived Fungus <i>Aspergillus</i> sp. 87 Open
Nine nitrogen-containing compounds including 1 new alkaloid, aspergilamide A (1), and 8 known alkaloids and dipeptides, pseurotin A (2), fumigaclavine C (3), isochaetominine (4), cyclo(L-Pro-L-tyr) (5), cyclo- trans-4-OH-(L)-Pro-(L)-Phe (6…
View article: Mono- and Dimeric Naphthalenones from the Marine-Derived Fungus Leptosphaerulina chartarum 3608
Mono- and Dimeric Naphthalenones from the Marine-Derived Fungus Leptosphaerulina chartarum 3608 Open
Five new naphthalenones, two enantiomers (−)-1 and (+)-1 leptothalenone A, (−)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one ((−)-2), (4S, 10R, 4’S)-leptotha-lenone B (5), (4R, 10S, 4’S)-leptothalenone B (6), …