Explanipedia

The gut microbiota is a determinant of sexual dimorphism in ALS-linked TDP43 mice Open

Evandro José Beraldi, Suk‐young Lee, Yulan Jiang, Isabel M. Rea, Rushda Phull , et al. · 2024

The mechanisms underlying the earlier onset and male predominance of amyotrophic lateral sclerosis (ALS), the most common form of human motoneuron disease, are poorly understood. Here we show that the gut microbiota protects against TDP43 …

1027P An open-label, multicenter, phase I/II study of GI-101, CD80-IgG4 Fc-IL2v, in advanced solid tumors (Part A of GII-101-P101; KEYNOTE-B59) Open

Byoung Chul Cho, Jia-Lin Lee, Byoung Yong Shim, Sang Joon Shin, Hyo Jin Lee , et al. · 2023

708P Final clinical outcomes of nationwide precision oncology pilot study; KOrean Precision Medicine Networking Group Study of MOlecular profiling guided therapy based on genomic alterations in advanced Solid tumors (KOSMOS) KCSG AL-20-05 Open

Tae‐Yop Kim, Su Yeon Kim, Jee Hyun Kim, Hyunah Jung, Yoon Ji Choi , et al. · 2023

OC 05.3 Incidence and Risk Factors for Venous Thromboembolism in Hospitalized Patients Across Three Major COVID-19 Variants in an Asian Cohort Open

Suk‐young Lee, Winnie Z.Y. Teo, Cynthia Ciwei Lim, Wei‐Ying Jen, Christopher Seungkyu Lee , et al. · 2023

A protocol for single nucleus RNA-seq from frozen skeletal muscle Open

Tyler Soule, Carly Sabine Pontifex, Nicole L. Rosin, Matthew M Joel, Suk‐young Lee , et al. · 2023

Single-cell technologies are a method of choice to obtain vast amounts of cell-specific transcriptional information under physiological and diseased states. Myogenic cells are resistant to single-cell RNA sequencing because of their large,…

A Protocol for Single Nucleus RNAseq from Frozen Skeletal Muscle Open

Tyler Soule, Carly Sabine Pontifex, Nicole L. Rosin, Matthew M Joel, Suk‐young Lee , et al. · 2022

Single cell technologies are a method of choice to obtain vast amounts of cell-specific transcriptional information under physiological and diseased states. Myogenic cells are resistant to single nucleus RNA sequencing (snRNAseq) due to th…

Role of phloretin as a sensitizer to TRAIL‑induced apoptosis in colon cancer Open

Jung-Lim Kim, Dae-Hee Lee, Cheol‐Ho Pan, Su Park, Sang-Cheul Oh , et al. · 2022

Phloretin is one of the apple polyphenols with anticancer activities. Since tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) serves important roles in inducing apoptosis, the present study examined the effect of phloretin on…

Tailored Therapy Based on Molecular Characteristics in Endometrial Cancer Open

Suk‐young Lee · 2021

Management of endometrial cancer, an adenocarcinoma of the endometrium which occupies most uterine corpus neoplasms, including uterine sarcomas, has been more relevant due to its increasing incidence. Extensive research on tumorigenesis mo…

Prognostic implication of systemic inflammatory markers in young patients with resectable colorectal cancer Open

Suk‐young Lee, Sun Il Lee, Byung Wook Min, Sang Cheul Oh · 2021

Systemic inflammation might be one of biologic factors that influence on prognosis of young CRC.

Preferences for life-sustaining treatment in Korean adults: a cross-sectional study Open

HyunChul Youn, Suk‐young Lee, Han‐Yong Jung, Shin Gyeom Kim, Seung Hyun Kim , et al. · 2021

Objectives Life-sustaining treatment is any treatment that serves to prolong life without reversing the underlying medical conditions, and includes cardiopulmonary resuscitation, mechanical ventilation, haemodialysis and left ventricular a…

Functional interpretation of<i>ATAD3A</i>variants in neuro-mitochondrial phenotypes Open

Zheng Yie Yap, Yohan Park, Saskia B. Wortmann, Adam C. Gunning, Suk‐young Lee , et al. · 2020

Background The ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane anchored protein involved in diverse processes including mitochondrial dynamics, mitochondrial DNA organization, and cholest…

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration Open

Ivana Kiroski, Yulan Jiang, Cezar Gavrilovici, Fan Gao, Suk‐young Lee , et al. · 2020

The glycoprotein Reelin maintains neuronal positioning and regulates neuronal plasticity in the adult brain. Reelin deficiency has been associated with neurological diseases. We recently showed that Reelin is depleted in mice with a target…

Pulmonary function is implicated in the prognosis of metastatic non-small cell lung cancer but not in extended disease small cell lung cancer Open

Suk‐young Lee, Yoon Ji Choi, Jae Hong Seo, Sung Yong Lee, Jung Sun Kim , et al. · 2019

Careful attention is required when chemotherapeutic agents are administered to patients with metastatic NSCLC with accompanying COPD with a FEV1 value of less than 80% predicted.

Inflammatory markers as prognostic indicators in pancreatic cancer patients who underwent gemcitabine-based palliative chemotherapy Open

Hong Jun Kim, Suk‐young Lee, Dae Sik Kim, Eun Joo Kang, Jung Sun Kim , et al. · 2018

Baseline inflammatory markers including NLR, PLR, and CRP-albumin ratio are useful in predicting survival rates in patients with PC. Combining these three markers is proven to be valuable.

Overexpression of Romo1 is an unfavorable prognostic biomarker and a predictor of lymphatic metastasis in non-small cell lung cancer patients Open

Hong Jun Kim, Min Jee Jo, Bo Ram Kim, Jung Lim Kim, Yoon A Jeong , et al. · 2018

The current study demonstrates that Romo1 induces lymphatic metastasis of NSCLC by modulating persistent inflammation and oxidative stress (ROS)/VEGF signaling. Lymphatic metastasis associated with elevated Romo1 was shown to be a key reas…

Correction: Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway Open

Bo Ram Kim, Yoon A Jeong, Yoo Jin Na, Seong Hye Park, Min Jee Jo , et al. · 2018

[This corrects the article DOI: 10.18632/oncotarget.21882.].

Current Strategies of Endocrine Therapy in Elderly Patients with Breast Cancer Open

Suk‐young Lee, Jae Hong Seo · 2018

Currently, the growing population of the elderly is one of biggest problems in terms of increase in geriatric diseases. Lack of data from large prospective studies on geriatric breast cancer patients often makes it difficult for clinicians…

Anatomical distribution and detection rate of colorectal neoplasms according to age in the colonoscopic screening of a Korean population Open

Suk‐young Lee, Wan Song, Sang Cheul Oh, Byung Wook Min, Sun Il Lee · 2018

These data could be the bases for earlier initiation of screening for colorectal neoplasms with total colonoscopy to detect clinically significant colorectal polyps.

Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway Open

Bo Ram Kim, Yoon A Jeong, Yoo Jin Na, Seong Hye Park, Min Jee Jo , et al. · 2017

Genipin, a major component of Gardenia jasminoides Ellis fruit, has been shown to inhibit the growth of gastric, prostate, and breast cancers. However, the anti-proliferative activity of genipin in colorectal cancer (CRC) has not be…

Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer Open

Dae-Hee Lee, Suk‐young Lee, Sang Cheul Oh · 2017

The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancer…

Reactive oxygen species modulator-1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients Open

Hong Jun Kim, Min Jee Jo, Bo Ram Kim, Jung Lim Kim, Yoon A Jeong , et al. · 2017

Romo1 overexpression in tumor tissue was significantly associated with survival in curatively resected colorectal cancer patients, suggesting Romo1 expression as a potential adverse prognostic marker. Increased Romo1 expression was found t…

The analysis of old person's blood pressure and blood lipid according to exercise frequency of combination exercise Open

Park Jin-Seoung, Suk‐young Lee, Kwangjun Lee · 2016

Aims: This study to analyze the effect of combination exercise program on blood pressure and blood lipid by exercise frequency on the elderly. Methods: Subject aged 65–70 years. Subjects divided into three groups: control group, exercise t…

RUNX3 inhibits the metastasis and angiogenesis of colorectal cancer Open

Bo Ram Kim, Myoung Hee Kang, Jung Lim Kim, Yoo Jin Na, Seong Hye Park , et al. · 2016

Recent studies have determined that inactivation of runt‑related transcription factor 3 (RUNX3) expression is highly associated with lymph node metastasis and poor prognosis in various types of cancer. However, the mechanism of RUNX3-media…

Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation<i>via</i>Mule in colorectal cancer cells Open

Seong Hye Park, Dae-Hee Lee, Jung Lim Kim, Bo Ram Kim, Yoo Jin Na , et al. · 2016

Metformin is an anti-diabetic drug with a promising anti-cancer potential. In this study, we show that subtoxic doses of metformin effectively sensitize human colorectal cancer (CRC) cells to tumor necrosis factor (TNF)-related apoptosis-i…

Positive response of a primary malignant pericardial mesothelioma to pemetrexed plus cisplatin followed by pemetrexed maintenance chemotherapy: A case report Open

Sang Mi Chung, Seong Ji Choi, Min-Jeong Kim, Jung Yoon Choi, Hong Jun Kim , et al. · 2016

Primary malignant pericardial mesothelioma (PMPM) is a rare tumor with poor prognosis. Surgery is the treatment of choice, but numerous cases are inoperable. For the treatment of inoperable or metastatic cases, systemic chemotherapy is req…

The Inositide Signaling Pathway As a Target for Treating Gastric Cancer and Colorectal Cancer Open

Hong Jun Kim, Suk‐young Lee, Sang Cheul Oh · 2016

Gastric cancer and colorectal cancer are the leading cause of cancer mortality and have a dismal prognosis. The introduction of biological agents to treat these cancers has resulted in improved outcomes, and combination chemotherapy with t…

Ataxia telangiectasia mutated (ATM), could it be another useful biomarker for the successful treatment with the poly (ADP-ribose) polymerase inhibitor? Open

Suk‐young Lee, Sang Cheul Oh · 2016

Gastric cancer is one of threatening health problems worldwide with poor treatment outcomes (1). Importance of selection of patients has been proposed as a key factor in improving outcomes of treatment with targeted therapies in patients d…

Advances of Targeted Therapy in Treatment of Unresectable Metastatic Colorectal Cancer Open

Suk‐young Lee, Sang Cheul Oh · 2016

Despite being one of the most frequently diagnosed cancers worldwide, prognosis of metastatic colorectal cancer (CRC) was poor. Development and introduction of biologic agents in treatment of patients with metastatic CRC have brought impro…

Changing strategies for target therapy in gastric cancer Open

Suk‐young Lee · 2016

In spite of a worldwide decrease in the incidence of gastric cancer, this malignancy still remains one of the leading causes of cancer mortality. Great efforts have been made to improve treatment outcomes in patients with metastatic gastri…

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