Sulaiman Mohammed Alnasser
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View article: Cardioprotective effects of Bassia indica via NF-κB and BCL-2/BAX modulation in isoproterenol-induced myocardial injury
Cardioprotective effects of Bassia indica via NF-κB and BCL-2/BAX modulation in isoproterenol-induced myocardial injury Open
Background Myocardial infarction (MI) is a fatal coronary heart disease that develops due to prolonged hypoxia. During MI progression, uncontrolled inflammation and apoptosis mediated by NF-κB and BAX/BCL-2 signaling pathways potentiate ca…
View article: Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis
Candesartan preserves aortic structure and function in cisplatin-treated rats by upregulating SIRT1/Nrf2/HO-1 signaling and suppressing oxidative stress, TLR-4/NF-κB signaling, and necroptosis Open
Background Cisplatin (CIS) is widely used in the treatment of several tumors. However, its use is associated with toxicity that contributes to long-term cardiovascular complications in cancer survivors. This study investigated whether the …
View article: Cognitive Load Effect on Intraoperative Learning – A Randomized Trial in Simulation-Based Settings
Cognitive Load Effect on Intraoperative Learning – A Randomized Trial in Simulation-Based Settings Open
Simulating a realistic OR environment intensified cognitive load and trainees impaired knowledge acquisition. Incorporating CL management strategies into surgical training may enhance trainee performance and adaptability in similar real-ti…
View article: S-Carboxymethylcysteine Mitigates Cyclophosphamide-Induced Hepatotoxicity by Modulating TLR-4/NF-κB Signaling and Redox Homeostasis
S-Carboxymethylcysteine Mitigates Cyclophosphamide-Induced Hepatotoxicity by Modulating TLR-4/NF-κB Signaling and Redox Homeostasis Open
View article: Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1
Ambroxol mitigates cyclophosphamide-induced liver injury by suppressing TLR-4/NF-κB signaling and oxidative stress and upregulating cytoglobin, TXNRD1 and HMGB1 Open
BACKGROUND Cyclophosphamide (CP) is a potent chemotherapeutic and immunosuppressant agent, but its hepatotoxicity remains a significant concern. Ambroxol (ABX) is a mucolytic agent with emerging beneficial effects against oxidative stress …
View article: Cellular distribution of estrogen receptors alpha in the rabbit ovary during pregnancy and lactation
Cellular distribution of estrogen receptors alpha in the rabbit ovary during pregnancy and lactation Open
Pregnancy and lactation is a critical period for rabbit production. Estrogen (E2) and estrogen receptors alpha (ERA) are essential during pregnancy and lactation and their importance stems from their role in ovarian activities. Despite ext…
View article: Pharmacological modulation of stem cells signaling pathway for therapeutic applications
Pharmacological modulation of stem cells signaling pathway for therapeutic applications Open
Stem cells have an exceptional capacity for self-renewal and differentiation and are at the forefront of therapeutics, offering promising solutions for repairing tissues, cancer treatment and the cure of degenerative diseases. Stem cell fa…
View article: Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development
Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development Open
The development of novel therapeutic drugs with enhanced efficacy has gained significant attention in recent years. In this study, we aimed to enhance the radical scavenging and antitumor activities of centaureidin through computationally …
View article: Mitigation of hepatic and gastric impairments induced by flunixin meglumine through co-administration with alpha lipoic acid in male rats
Mitigation of hepatic and gastric impairments induced by flunixin meglumine through co-administration with alpha lipoic acid in male rats Open
Long term use of Flunixin meglumine produces many gastric and hepatic hazards. The current study aimed to investigate using Alpha lipoic acid (ALA) for treating flunixin meglumine (FM)-induced liver and gastrointestinal problems in male ra…
View article: Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications
Revisiting the approaches to DNA damage detection in genetic toxicology: insights and regulatory implications Open
Genetic toxicology is crucial for evaluating the potential risks of chemicals and drugs to human health and the environment. The emergence of high-throughput technologies has transformed this field, providing more efficient, cost-effective…
View article: Comparative Neuropharmacological Evaluation of Two Herbs (Rosemary and Basil) with Culinary, Medicinal, and Cultural Significance
Comparative Neuropharmacological Evaluation of Two Herbs (Rosemary and Basil) with Culinary, Medicinal, and Cultural Significance Open
Background Rosemary ( Rosmarinus officinalis ) is a perennial herb, while basil ( Ocimum basilicum ) is an annual herb. Both are utilized in culinary practices and have antioxidant as well as anti-inflammatory properties. However, their ne…
View article: Acute and Subacute Oral Toxicity Assessment of The Polysaccharides Extracted from <i>Clinacanthus nutans</i> Leaves: A Preclinical Model for Drug Safety Screening
Acute and Subacute Oral Toxicity Assessment of The Polysaccharides Extracted from <i>Clinacanthus nutans</i> Leaves: A Preclinical Model for Drug Safety Screening Open
Emerging investigations have indicated that many plant polysaccharides may be beneficial for treating metabolic diseases. To date, the therapeutic efficacy and potential toxicity of polysaccharides extracted from Clinacanthus nutans (C. nu…
View article: From gut to liver: organoids as platforms for next-generation toxicology assessment vehicles for xenobiotics
From gut to liver: organoids as platforms for next-generation toxicology assessment vehicles for xenobiotics Open
Traditional toxicological assessment relied heavily on 2D cell cultures and animal models of study, which were inadequate for the precise prediction of human response to chemicals. Researchers have now shifted focus on organoids for toxico…
View article: Retraction notice to “Tetraclinis articulata (Vahl) Mast. essential oil as a promising source of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory and dermatoprotective properties: In vitro and in silico evidence” [Heliyon 10 (2024) e23084]
Retraction notice to “Tetraclinis articulata (Vahl) Mast. essential oil as a promising source of bioactive compounds with antimicrobial, antioxidant, anti-inflammatory and dermatoprotective properties: In vitro and in silico evidence” [Heliyon 10 (2024) e23084] Open
[This retracts the article DOI: 10.1016/j.heliyon.2023.e23084.].
View article: Correction: Computational evaluation of efflux pump homologues and lignans as potent inhibitors against multidrug-resistant Salmonella typhi
Correction: Computational evaluation of efflux pump homologues and lignans as potent inhibitors against multidrug-resistant Salmonella typhi Open
[This corrects the article DOI: 10.1371/journal.pone.0303285.].
View article: The effect of norethisterone acetate on the uterine telocytes, immune cells and progesterone receptors in albino rats
The effect of norethisterone acetate on the uterine telocytes, immune cells and progesterone receptors in albino rats Open
This study is the first attempt to examine the effects of NETA on immune cells and telocytes. The results of this study form an important knowledge base for the development of new information on the mechanism of contraceptive action of NET…
View article: <i>Thymus serpyllum</i> L. Essential Oil: Phytochemistry and <i>in Vitro and in Silico Screening of Its</i> Antimicrobial, Antioxidant and Anti-Inflammatory Properties
<i>Thymus serpyllum</i> L. Essential Oil: Phytochemistry and <i>in Vitro and in Silico Screening of Its</i> Antimicrobial, Antioxidant and Anti-Inflammatory Properties Open
View article: Biological Potential and Chemical Characterization of <i>Juniperus oxycedrus</i> Leaves and Seed Cones
Biological Potential and Chemical Characterization of <i>Juniperus oxycedrus</i> Leaves and Seed Cones Open
View article: HPLC-DAD Profiling and Diuretic Effect of <i>Solanum elaeagnifolium</i> (Cav.) Aqueous Extract: A Combined Experimental and Computational Approach
HPLC-DAD Profiling and Diuretic Effect of <i>Solanum elaeagnifolium</i> (Cav.) Aqueous Extract: A Combined Experimental and Computational Approach Open
View article: Podocyte-related biomarkers' role in evaluating renal toxic effects of silver nanoparticles with the possible ameliorative role of resveratrol in adult male albino rats
Podocyte-related biomarkers' role in evaluating renal toxic effects of silver nanoparticles with the possible ameliorative role of resveratrol in adult male albino rats Open
Extensive uses of silver nanoparticles (Ag NPs) in different industries result in exposure to these nanoparticle imperatives in our daily lives. Resveratrol is found in many plants as a natural compound. The present study aimed to estimate…
View article: Estrogen receptor immunoexpression in the ovary of the rabbit after ovulation-inducing application of human chorionic gonadotropin
Estrogen receptor immunoexpression in the ovary of the rabbit after ovulation-inducing application of human chorionic gonadotropin Open
Background One of the most popular animal species in both animal husbandry and lab work is the rabbit. Consequently, there is a significant need to improve rabbit reproductive performance. Estrogens are responsible for regulating ovarian a…
View article: The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors.
The Correlation of Serum Adropin with Cardiovascular Risk Factors in the Experimental Rat Model of Chronic Kidney Disease and Its Implication in the Ameliorative Effect of Angiotensin-Converting Enzyme Inhibitors. Open
Adropin levels were significantly correlated with most CVD risk factors in CKD and captopril-treated CKD rats, indicating a role for adropin in the pathogenesis of CVD in CKD. It also refers to its implication in the ameliorative effect of…
View article: Integrating Computational Modeling and Experimental Validation to Unveil Tyrosinase Inhibition Mechanisms of Flavonoids from <i>Alhagi graecorum</i>
Integrating Computational Modeling and Experimental Validation to Unveil Tyrosinase Inhibition Mechanisms of Flavonoids from <i>Alhagi graecorum</i> Open
Flavonoids, natural compounds ubiquitous in the human diet, are esteemed for their multifaceted pharmacological properties. The tyrosinase inhibitory capacity of five flavonoids from Alhagi graecorum was investigated through a compr…
View article: Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ
Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ Open
Background: Heavy metals can cause serious health problems that affect different organs. Cadmium (Cd) is an environmental contaminant known for its toxicological consequences on different organs. Hepatotoxicity is a serious effect of expos…
View article: Oxidative Stress, Inflammation, and Altered Lymphocyte E-NTPDase Are Implicated in Acute Dyslipidemia in Rats: Protective Role of Arbutin
Oxidative Stress, Inflammation, and Altered Lymphocyte E-NTPDase Are Implicated in Acute Dyslipidemia in Rats: Protective Role of Arbutin Open
Background/Objectives: Dyslipidemia is frequently linked to various disorders, and its clinical relevance is now recognized. The role of inflammation and oxidative stress (OS) in dyslipidemia has been acknowledged. This study assessed the …
View article: Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis
Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis Open
View article: Characterization of giant endocrine cells in the fundic stomach of African catfish (Clarias gariepinus) demonstrated by histochemical, immunohistochemical and ultrastructure microscopy methods suggesting their role in immunity
Characterization of giant endocrine cells in the fundic stomach of African catfish (Clarias gariepinus) demonstrated by histochemical, immunohistochemical and ultrastructure microscopy methods suggesting their role in immunity Open
Endocrine cells in the fundic stomach of Clarias gariepinus were characterized in this work using transmission electron microscopy, immunohistochemistry, and histochemistry. Performic acid mixed with alcian blue pH2.5 and silver stain were…
View article: In Vivo, Exploring the Antidiabetic and Antimicrobial Effects of Okra Extract in Streptozotocin-Induced Hyperglycemic Conditions
In Vivo, Exploring the Antidiabetic and Antimicrobial Effects of Okra Extract in Streptozotocin-Induced Hyperglycemic Conditions Open
This paper presents a comprehensive analysis of the phytochemical composition, quality parameters followed by antimicrobial and antidiabetic activity of Abelmoschus esculentus (okra) plant material. The study involved macroscopic examinati…
View article: The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study
The effect of Norethisterone acetate on the uterus of albino rats: histological, histochemical and ultrastructure study Open
Background Norethisterone acetate (NETA), also known as norethindrone acetate is a progestogens medication that is widely used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders as abnormal…
View article: Exploring the antidiabetic and anti-inflammatory potential of Lavandula officinalis essential oil: In vitro and in silico insights
Exploring the antidiabetic and anti-inflammatory potential of Lavandula officinalis essential oil: In vitro and in silico insights Open