Wai Leong Tam
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View article: Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling
Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling Open
Ferroptosis, an iron‐dependent cell death driven by lipid peroxidation, is a promising therapeutic target in colorectal cancer (CRC); however, its regulation remains unclear. Here, Pirin (PIR) is recognized as a ferroptosis suppressor that…
View article: Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer
Induction of a metabolic switch from glucose to ketone metabolism programs ketogenic diet-induced therapeutic vulnerability in lung cancer Open
Tumor-initiating cells (TICs) preferentially reside in poorly vascularized, nutrient-stressed tumor regions, yet how they adapt to glucose limitation is unclear. We show that lung TICs, unlike bulk tumor cells, can switch from glucose to k…
View article: Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer
Circulating enolase 1 as a diagnostic biomarker for early-stage breast cancer Open
Diagnosis of stage 1 breast cancer is challenging as small tumors are often left undetected by conventional imaging techniques. In addition, ~80% of detected breast masses are classified as benign, which means that a large proportion of di…
View article: Advancing Cancer Biology: Highlights from the 2025 FASEB SRC on Cellular Plasticity in Cancer
Advancing Cancer Biology: Highlights from the 2025 FASEB SRC on Cellular Plasticity in Cancer Open
The inaugural FASEB Science Research Conference (SRC) on Cellular Plasticity in Cancer was held in May 2025 in Hong Kong SAR, China. This event brought together leading experts to discuss cutting-edge research centered on cancer cell plast…
View article: Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers
Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers Open
Rationale: Mutations in the KRAS gene drive many cancers, yet targeting KRAS mutants remains a challenge. Here, we address this hurdle by utilizing a nucleic acid-based therapeutic strategy delivered via extracellular …
View article: MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance
MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance Open
Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementatio…
View article: A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines
A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines Open
The human genome contains instructions to transcribe more than 200,000 RNAs. However, many RNA transcripts are generated from the same gene, resulting in alternative isoforms that are highly similar and that remain difficult to quantify. T…
View article: p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis
p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis Open
Mechanisms underlying p53-mediated protection of the replicating genome remain elusive, despite the quintessential role of p53 in maintaining genomic stability. Here, we uncover an unexpected function of p53 in curbing replication stress b…
View article: Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer
Customised design of antisense oligonucleotides targeting EGFR driver mutants for personalised treatment of non-small cell lung cancer Open
View article: MS-CETSA functional proteomics uncovers new DNA-repair programs leading to Gemcitabine resistance
MS-CETSA functional proteomics uncovers new DNA-repair programs leading to Gemcitabine resistance Open
Mechanisms for resistance to cytotoxic cancer drugs are dependent on dynamic changes in the biochemistry of cellular pathways, information which is hard to obtain at the systems level. Here we use a deep functional proteomics implementatio…
View article: PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression
PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression Open
View article: Supplementary Tables from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Supplementary Tables from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Supplementary Tables
View article: Data from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Data from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Non–small cell lung cancers (NSCLC) in nonsmokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET and fusions involving ALK and RET. In addition to occurring in nonsmokers, alteration…
View article: Supplementary Figures from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Supplementary Figures from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Supplementary Figures
View article: Supplementary Figures from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Supplementary Figures from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Supplementary Figures
View article: Supplementary Tables from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Supplementary Tables from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Supplementary Tables
View article: Data from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Data from Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Non–small cell lung cancers (NSCLC) in nonsmokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET and fusions involving ALK and RET. In addition to occurring in nonsmokers, alteration…
View article: Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations
Oncogene-Driven Non–Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations Open
Non–small cell lung cancers (NSCLC) in nonsmokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET and fusions involving ALK and RET. In addition to occurring in nonsmokers, alterations in these “nonsmoking-related onco…
View article: Cancer Hallmarks: Piecing the Puzzle Together
Cancer Hallmarks: Piecing the Puzzle Together Open
View article: Deep learning based CETSA feature prediction cross multiple cell lines with latent space representation
Deep learning based CETSA feature prediction cross multiple cell lines with latent space representation Open
Mass spectrometry-coupled cellular thermal shift assay (MS-CETSA), a biophysical principle-based technique that measures the thermal stability of proteins at the proteome level inside the cell, has contributed significantly to the understa…
View article: Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity Open
The SLC7A11/xCT cystine and glutamate antiporter has emerged as an attractive target for cancer therapy due to its selective overexpression in multiple cancers and its role in preventing ferroptosis. Utilizing pharmacological and genetic a…
View article: Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment
Mfap4: a promising target for enhanced liver regeneration and chronic liver disease treatment Open
View article: Author Correction: Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer
Author Correction: Multimodal metabolomics pinpoint new metabolic vulnerability in colorectal cancer Open
View article: Deep Learning Based CETSA Feature Prediction cross Multiple Cell Lines with Latent Space Representation
Deep Learning Based CETSA Feature Prediction cross Multiple Cell Lines with Latent Space Representation Open
Cellular Thermal Shift Assay (CETSA), a biophysical principle-based technique measuring the protein thermal stability inside cell, has contributed significantly to the understanding of drug mechanisms of action (MoAs) and the dissection of…
View article: SemiGNN-PPI: Self-Ensembling Multi-Graph Neural Network for Efficient and Generalizable Protein–Protein Interaction Prediction
SemiGNN-PPI: Self-Ensembling Multi-Graph Neural Network for Efficient and Generalizable Protein–Protein Interaction Prediction Open
Protein-protein interactions (PPIs) are crucial in various biological processes and their study has significant implications for drug development and disease diagnosis. Existing deep learning methods suffer from significant performance deg…
View article: Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma
Multimodal molecular landscape of response to Y90-resin microsphere radioembolization followed by nivolumab for advanced hepatocellular carcinoma Open
Background Combination therapy with radioembolization (yttrium-90)-resin microspheres) followed by nivolumab has shown a promising response rate of 30.6% in a Phase II trial (CA209-678) for advanced hepatocellular carcinoma (HCC); however,…
View article: Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrence
Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrence Open
Hepatocellular carcinomas (HCC) are driven by various etiologies and molecular diversity at presentation. Patient prognosis post-surgery is generally dismal, and the majority respond poorly to adjuvant targeted and/or immuno-therapies. Tum…
View article: Author Correction: The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer
Author Correction: The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer Open
View article: Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure
Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure Open
Non-small cell lung cancers (NSCLCs) in non-smokers are mostly driven by mutations in the oncogenes EGFR, ERBB2, and MET , and fusions involving ALK and RET . We term these “non-smoking-related oncogenes” (NSROs). In addition to occurring …
View article: The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer
The effect of inhibition of receptor tyrosine kinase AXL on DNA damage response in ovarian cancer Open