Suman C. Nath
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View article: A retinoid analogue, TTNPB, promotes clonal expansion of human pluripotent stem cells by upregulating CLDN2 and HoxA1
A retinoid analogue, TTNPB, promotes clonal expansion of human pluripotent stem cells by upregulating CLDN2 and HoxA1 Open
Enzymatic dissociation of human pluripotent stem cells (hPSCs) into single cells during routine passage leads to massive cell death. Although the Rho-associated protein kinase inhibitor, Y-27632 can enhance hPSC survival and proliferation …
View article: Overcoming the Variability of iPSCs in the Manufacturing of Cell-Based Therapies
Overcoming the Variability of iPSCs in the Manufacturing of Cell-Based Therapies Open
Various factors are known to contribute to the diversity of human induced pluripotent stem cells (hiPSCs). Among these are the donor’s genetic background and family history, the somatic cell source, the iPSC reprogramming method, and the c…
View article: Cell-Based Therapy Manufacturing in Stirred Suspension Bioreactor: Thoughts for cGMP Compliance
Cell-Based Therapy Manufacturing in Stirred Suspension Bioreactor: Thoughts for cGMP Compliance Open
Cell-based therapy (CBT) is attracting much attention to treat incurable diseases. In recent years, several clinical trials have been conducted using human pluripotent stem cells (hPSCs), and other potential therapeutic cells. Various priv…
View article: Post-Passage rock inhibition induces cytoskeletal aberrations and apoptosis in Human embryonic stem cells
Post-Passage rock inhibition induces cytoskeletal aberrations and apoptosis in Human embryonic stem cells Open
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) are prone to anoikis after single cell dissociation. The small molecule, Y-27632 is known to increase survival of hESCs and hiPSCs by inhibiting the Rho-associa…
View article: Kinetic modeling of human induced pluripotent stem cell expansion in suspension culture
Kinetic modeling of human induced pluripotent stem cell expansion in suspension culture Open
To date, practical application of mathematical models for model-based design of stem cell expansion processes is limited. Nevertheless, the first attempts show vast potential of this approach for the improvement of expansion process perfor…
View article: Integrated Biologics Manufacturing in Stirred-Suspension Bioreactor: A Stem Cell Perspective
Integrated Biologics Manufacturing in Stirred-Suspension Bioreactor: A Stem Cell Perspective Open
Stem cell therapy is garnering attention as several clinical trials have taken place in the recent years by using human pluripotent stem cells (hPSCs). Hundreds of biotechnological companies are investing to find a permanent cure for diffi…