Suman Ranjit
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View article: OR30-08 Pharmacological Inhibitors of Glutamate Transport and Metabolism Suppress Oxidative Phosphorylation in Invasive Lobular Carcinoma
OR30-08 Pharmacological Inhibitors of Glutamate Transport and Metabolism Suppress Oxidative Phosphorylation in Invasive Lobular Carcinoma Open
Disclosure: D. Mobin: None. A.O. Olukoya: None. S. Bahnassy: None. S. Ranjit: None. T. Young: None. R.B. Riggins: None. Compared to other histologic subtypes of breast cancer, Invasive Lobular Carcinoma (ILC) is characterized by unique met…
View article: GSLab: open-source platform for advanced phasor analysis in fluorescence microscopy
GSLab: open-source platform for advanced phasor analysis in fluorescence microscopy Open
Summary GSLab addresses the need for effective image analysis tools in fluorescence microscopy by providing an open-source platform that enhances traditional phasor analysis with advanced features. Key capabilities include machine learning…
View article: Advancements in time-resolved detection for in vivo multiphoton microscopy of human skin
Advancements in time-resolved detection for in vivo multiphoton microscopy of human skin Open
View article: Standardizing multiphoton microscopy for clinical melanoma diagnosis
Standardizing multiphoton microscopy for clinical melanoma diagnosis Open
View article: GSLab: Open-Source Platform for Advanced Phasor Analysis in Fluorescence Microscopy
GSLab: Open-Source Platform for Advanced Phasor Analysis in Fluorescence Microscopy Open
GSLab addresses the need for effective image analysis tools in fluorescence microscopy by providing an open-source platform that enhances traditional phasor analysis with advanced features. Key capabilities include machine learning-based c…
View article: Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma
Glutamate Transport Proteins and Metabolic Enzymes are Poor Prognostic Factors in Invasive Lobular Carcinoma Open
Invasive Lobular Carcinoma (ILC) is a subtype of breast cancer characterized by distinct biological features, and limited glucose uptake coupled with increased reliance on amino acid and lipid metabolism. Our prior studies highlight the im…
View article: Establishing Riboglow-FLIM to visualize noncoding RNAs inside live zebrafish embryos
Establishing Riboglow-FLIM to visualize noncoding RNAs inside live zebrafish embryos Open
View article: Fibrosis quantification using multiphoton excitation imaging of picrosirius red stained cardiac tissue
Fibrosis quantification using multiphoton excitation imaging of picrosirius red stained cardiac tissue Open
Traditional methodologies for fibrosis quantification involve histological measurements, staining with Masson’s trichrome and picrosirius red (PSR), and label-free imaging using second harmonic generation (SHG). The difficulty of label-fre…
View article: Riluzole Suppresses Growth and Enhances Response to Endocrine Therapy in ER+ Breast Cancer
Riluzole Suppresses Growth and Enhances Response to Endocrine Therapy in ER+ Breast Cancer Open
Background Resistance to endocrine therapy in estrogen receptor–positive (ER+) breast cancer remains a significant clinical problem. Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis. A benzothiazole-based glutama…
View article: Visualizing orthogonal RNAs simultaneously in live mammalian cells by fluorescence lifetime imaging microscopy (FLIM)
Visualizing orthogonal RNAs simultaneously in live mammalian cells by fluorescence lifetime imaging microscopy (FLIM) Open
Visualization of RNAs in live cells is critical to understand biology of RNA dynamics and function in the complex cellular environment. Detection of RNAs with a fluorescent marker frequently involves genetically fusing an RNA aptamer tag t…
View article: Supplemental Data for "Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer"
Supplemental Data for "Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer" Open
Supplemental Figures and Legends for Olukoya et al 2023 (https://doi.org/10.1101/2020.07.30.227561)
View article: Supplemental Data for "Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer"
Supplemental Data for "Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer" Open
Supplemental Figures and Legends for Olukoya et al 2023 (https://doi.org/10.1101/2020.07.30.227561)
View article: Supplemental Data for "Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer"
Supplemental Data for "Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer" Open
Supplemental Figures and Legends for Olukoya et al 2023 (https://doi.org/10.1101/2020.07.30.227561)
View article: The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice
The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice Open
Nonalcoholic steatohepatitis (NASH) is the most common chronic liver disease in the US, partly due to the increasing incidence of metabolic syndrome, obesity, and type 2 diabetes. The roles of bile acids and their receptors, such as the nu…
View article: Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers
Oral N-acetylcysteine decreases IFN-γ production and ameliorates ischemia-reperfusion injury in steatotic livers Open
Type 1 Natural Killer T-cells (NKT1 cells) play a critical role in mediating hepatic ischemia-reperfusion injury (IRI). Although hepatic steatosis is a major risk factor for preservation type injury, how NKT cells impact this is understudi…
View article: Type 1 Innate Lymphoid Cells Are Proinflammatory Effector Cells in Ischemia-Reperfusion Injury of Steatotic Livers
Type 1 Innate Lymphoid Cells Are Proinflammatory Effector Cells in Ischemia-Reperfusion Injury of Steatotic Livers Open
Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine. Group 1 ILCs, comprised of conventional natural killer cells (cNKs) an…
View article: Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH
Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH Open
The results revealed a novel pathway of estrogen-mediated cross-talk between hepatocytes and HSCs that may contribute to sex differences in NAFLD through an anti-fibrogenic function of the S1P/S1PR3 axis. This pathway is susceptible to pha…
View article: Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice
Empagliflozin Treatment Attenuates Hepatic Steatosis by Promoting White Adipose Expansion in Obese TallyHo Mice Open
Sodium-glucose co-transporters (SGLTs) serve to reabsorb glucose in the kidney. Recently, these transporters, mainly SGLT2, have emerged as new therapeutic targets for patients with diabetes and kidney disease; by inhibiting glucose reabso…
View article: Linear Combination Properties of the Phasor Space in Fluorescence Imaging
Linear Combination Properties of the Phasor Space in Fluorescence Imaging Open
The phasor approach to fluorescence lifetime imaging, and more recently hyperspectral fluorescence imaging, has increased the use of these techniques, and improved the ease and intuitiveness of the data analysis. The fit-free nature of the…
View article: Reduction of fibrosis and immune suppressive cells in ErbB2-dependent tumorigenesis by an LXR agonist
Reduction of fibrosis and immune suppressive cells in ErbB2-dependent tumorigenesis by an LXR agonist Open
One of the central challenges for cancer therapy is the identification of factors in the tumor microenvironment that increase tumor progression and prevent immune surveillance. One such element associated with breast cancer is stromal fibr…
View article: S-adenosyl-<scp>l</scp>-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling
S-adenosyl-<span>l</span>-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling Open
The S-adenosylhomocysteine (SAH) hydrolyzing enzyme AHCY functionally links the circadian clock to methionine metabolism.
View article: Lateral diffusion of CD14 and TLR2 in macrophage plasma membrane assessed by raster image correlation spectroscopy and single particle tracking
Lateral diffusion of CD14 and TLR2 in macrophage plasma membrane assessed by raster image correlation spectroscopy and single particle tracking Open
View article: Blind Resolution of Lifetime Components in Individual Pixels of Fluorescence Lifetime Images Using the Phasor Approach
Blind Resolution of Lifetime Components in Individual Pixels of Fluorescence Lifetime Images Using the Phasor Approach Open
The phasor approach is used in fluorescence lifetime imaging microscopy for several purposes, notably to calculate the metabolic index of single cells and tissues. An important feature of the phasor approach is that it is a fit-free method…
View article: Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer
Riluzole suppresses growth and enhances response to endocrine therapy in ER+ breast cancer Open
Background Resistance to endocrine therapy in estrogen receptor-positive (ER+) breast cancer remains a significant clinical problem. Riluzole is FDA-approved for the treatment of amyotrophic lateral sclerosis. A benzothiazole-based glutama…
View article: 4528 Sirtuin 3 activation as a potential renoprotective therapy in a mouse model of Alport syndrome
4528 Sirtuin 3 activation as a potential renoprotective therapy in a mouse model of Alport syndrome Open
OBJECTIVES/GOALS: Sirtuin 3 (Sirt3), a mitochondrial NAD + -dependent deacetylase, is decreased in diverse models of kidney disease, and Sirt3 activation prevents disease progression in many of those models. We are investigating if pharmac…
View article: Phasor approach to autofluorescence lifetime imaging FLIM can be a quantitative biomarker of chronic renal parenchymal injury
Phasor approach to autofluorescence lifetime imaging FLIM can be a quantitative biomarker of chronic renal parenchymal injury Open
View article: BMAL1 Associates with NOP58 in the Nucleolus and Contributes to Pre-rRNA Processing
BMAL1 Associates with NOP58 in the Nucleolus and Contributes to Pre-rRNA Processing Open
View article: Resolution of 4 components in the same pixel in FLIM images using the phasor approach
Resolution of 4 components in the same pixel in FLIM images using the phasor approach Open
In several cellular systems, the phasor FLIM approach has shown the existence of more than 2 components in the same pixel, a typical example being free and bound NADH. In order to properly quantify the concentrations and the spatial distri…
View article: Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice
Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet–fed mice Open
View article: Image Correlation Microscopy Approach to Study Collagen Accumulation for Distinguishing Recurrence in Liver Cancer Patients
Image Correlation Microscopy Approach to Study Collagen Accumulation for Distinguishing Recurrence in Liver Cancer Patients Open