Sumanun Suwunnakorn
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View article: Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects
Transcriptomic and functional characterization of megakaryocytic-derived platelet-like particles: impaired aggregation and prominent anti-tumor effects Open
Platelet-like particles (PLPs), derived from megakaryocytic cell lines MEG-01 and K-562, are widely used as a surrogate to study platelet formation and function. We demonstrate by RNA-Seq that PLPs are transcriptionally distinct from plate…
View article: Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection
Novel Mechanism of Microvesicle Regulation by the Antiviral Protein Tetherin During HIV Infection Open
Background Microvesicles are cell membrane–derived vesicles that have been shown to augment inflammation. Specifically, monocyte‐derived microvesicles (MDMVs), which can express the coagulation protein tissue factor, contribute to thrombus…
View article: Monocytes complexed to platelets differentiate into functionally deficient dendritic cells
Monocytes complexed to platelets differentiate into functionally deficient dendritic cells Open
In addition to their role in hemostasis, platelets store numerous immunoregulatory molecules such as CD40L, TGFβ, β2-microglobulin, and IL-1β and release them upon activation. Previous studies indicate that activated platelets form transie…
View article: <i>FKS2</i> and <i>FKS3</i> Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility
<i>FKS2</i> and <i>FKS3</i> Genes of Opportunistic Human Pathogen Candida albicans Influence Echinocandin Susceptibility Open
Candida albicans , a prevailing opportunistic fungal pathogen of humans, has a diploid genome containing three homologous FKS genes that are evolutionarily conserved. One of these, the essential gene FKS1 , encodes the catalytic subunit of…
View article: Chromosome 5 of Human Pathogen Candida albicans Carries Multiple Genes for Negative Control of Caspofungin and Anidulafungin Susceptibility
Chromosome 5 of Human Pathogen Candida albicans Carries Multiple Genes for Negative Control of Caspofungin and Anidulafungin Susceptibility Open
Candida albicans is an important fungal pathogen with a diploid genome that can adapt to caspofungin, a major drug from the echinocandin class, by a reversible loss of one copy of chromosome 5 (Ch5). Here, we explore a hypothesis that more…