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View article: Heteromultivalente Nanogele als hochwirksame Inhibitoren von <i>Pseudomonas aeruginosa</i>
Heteromultivalente Nanogele als hochwirksame Inhibitoren von <i>Pseudomonas aeruginosa</i> Open
Zusammenfassung Die zunehmende Verbreitung mikrobieller Resistenzen erfordert neue antibakterielle Konzepte zur gezielten Erkennung und Abtötung pathogener Bakterien. In dem vorliegenden Artikel stellen wir die Synthese eines heteromultiva…
View article: Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i>
Heteromultivalent Nanogels as Highly Potent Inhibitors of <i>Pseudomonas Aeruginosa</i> Open
The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aerug…
View article: Mechanical stability of individual bacterial cells under different osmotic pressure conditions: a nanoindentation study of <i>Pseudomonas aeruginosa</i>
Mechanical stability of individual bacterial cells under different osmotic pressure conditions: a nanoindentation study of <i>Pseudomonas aeruginosa</i> Open
Nanomechanical maps to test the mechanical response of the outer envelope of Pseudomonas aeruginosa were obtained utilizing atomic force microscopy in force–volume mode in the low range of loading forces when exposed to hypotonic (Milli-Q …
View article: Polysialosides Outperform Sulfated Analogs for Binding with SARS‐CoV‐2
Polysialosides Outperform Sulfated Analogs for Binding with SARS‐CoV‐2 Open
Both polysialosides and polysulfates are known to interact with the receptor binding domain (RBD) of the SARS‐CoV‐2 spike protein. However, a comprehensive site by site analysis of their binding affinities and potential synergistic antivir…
View article: Lignin-Based Mucus-Mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity
Lignin-Based Mucus-Mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity Open
Mucus is a complex hydrogel that acts as a defensive and protective barrier in various parts of the human body. The rise in the level of viral infections has underscored the importance of advancing research into mucus-mimicking hydrogels f…
View article: Polysialosides outperform sulfated analogs for the inhibition of SARS-CoV-2
Polysialosides outperform sulfated analogs for the inhibition of SARS-CoV-2 Open
Both polysialosides and polysulfates are known to interact with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. However, a comprehensive site by site analysis of their binding affinities and potential synergistic antivir…
View article: Lignin-based Mucin-mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity
Lignin-based Mucin-mimicking Antiviral Hydrogels with Enzyme Stability and Tunable Porosity Open
Mucus is a complex hydrogel acting as a defensive and protective barrier in various parts of the human body. The structure and composition of mucus play an important role in maintaining barrier properties by acting as a filter for the diff…
View article: ADAPTING THE EURASIAN H5 TAQMAN RT-QPCR ASSAY FOR THE DETECTION OF AVIAN INFLUENZA STRAINS CIRCULATING IN INDIA
ADAPTING THE EURASIAN H5 TAQMAN RT-QPCR ASSAY FOR THE DETECTION OF AVIAN INFLUENZA STRAINS CIRCULATING IN INDIA Open
The development of molecular diagnostic for avian influenza virus (AIV) is a continuous process due to evolution of virus after each passing outbreak. The molecular tests need to be reviewed after each outbreak for obtaining consistent lab…
View article: Synthesis and Comparison of Linear Polymannosides for Direct Binding with <i>Escherichia coli</i>
Synthesis and Comparison of Linear Polymannosides for Direct Binding with <i>Escherichia coli</i> Open
Here, the synthesis of linear polyglycerols bearing multiple copies of mono and dimannosides (LPG 40 Man 0.60 and LPG 40 (Manα1,2Man) 0.60 ) is demonstrated. A method based on label‐free microscale thermophoresis is optimized to determine …
View article: Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins
Design, Synthesis, and Biomedical Applications of Glycotripods for Targeting Trimeric Lectins Open
In the last decades, various efforts have been made to synthesize optimal glycotripods for targeting trimeric glycoproteins like asialoglycoprotein receptor, hemagglutinin, and langerin. All these trimeric glycoproteins have sugar binding …
View article: Scaffold Flexibility Controls Binding of Herpes Simplex Virus Type 1 with Sulfated Dendritic Polyglycerol Hydrogels Fabricated by Thiol‐Maleimide Click Reaction
Scaffold Flexibility Controls Binding of Herpes Simplex Virus Type 1 with Sulfated Dendritic Polyglycerol Hydrogels Fabricated by Thiol‐Maleimide Click Reaction Open
Herpes Simplex Virus‐1 (HSV‐1) with a diameter of 155–240 nm uses electrostatic interactions to bind with the heparan sulfate present on the cell surface to initiate infection. In this work, the initial contact using polysulfate‐functional…
View article: Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size
Glycosylated MoS<sub>2</sub> Sheets for Capturing and Deactivating <i>E. coli</i> Bacteria: Combined Effects of Multivalent Binding and Sheet Size Open
Molybdenum disulfide (MoS 2 ) holds great promise for antibacterial applications owing to its strong photothermal performance and biocompatibility. Most of its antibacterial explorations have sought enhanced antibacterial potency through d…
View article: Polyglycerol‐Based Mucus‐Inspired Hydrogels
Polyglycerol‐Based Mucus‐Inspired Hydrogels Open
The mucus layer is a hydrogel network that covers mucosal surfaces of the human body. Mucus has important protective properties that are related to its unique rheological properties, which are based on mucins being the main glycoprotein co…
View article: Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells
Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells Open
The recently emerging stem‐cell artificial niche engineering in induced pluripotent stem cell (iPSCs) 3D cultures has provided enormous opportunities to fully utilize the potential of these cells in biomedical applications. Although a full…
View article: Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors
Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors Open
A broad-spectrum heteromultivalent influenza inhibitor is developed by using the host cell membrane on an inverted virus scaffold.
View article: Mucin‐Inspired, High Molecular Weight Virus Binding Inhibitors Show Biphasic Binding Behavior to Influenza A Viruses
Mucin‐Inspired, High Molecular Weight Virus Binding Inhibitors Show Biphasic Binding Behavior to Influenza A Viruses Open
Multivalent binding inhibitors are a promising new class of antivirals that prevent virus infections by inhibiting virus binding to cell membranes. The design of these inhibitors is challenging as many properties, for example, inhibitor si…
View article: Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors Open
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm size…
View article: Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors
Adaptive Flexible Sialylated Nanogels as Highly Potent Influenza A Virus Inhibitors Open
Flexible multivalent 3D nanosystems that can deform and adapt onto the virus surface via specific ligand–receptor multivalent interactions can efficiently block virus adhesion onto the cell. We here report on the synthesis of a 250 nm size…
View article: Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action
Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action Open
In this study, we demonstrate the concept of “topology‐matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle‐based inhibitor (nano‐inhibitor) that has a matched nanotopolog…
View article: Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action
Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action Open
In this study, we demonstrate the concept of “topology‐matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle‐based inhibitor (nano‐inhibitor) that has a matched nanotopolog…
View article: Non-ionic small amphiphile based nanostructures for biomedical applications
Non-ionic small amphiphile based nanostructures for biomedical applications Open
Amphiphiles in action: self-assembled nanostructures for drug delivery and imaging.
View article: Strong Inhibition of Cholera Toxin B Subunit by Affordable, Polymer-Based Multivalent Inhibitors
Strong Inhibition of Cholera Toxin B Subunit by Affordable, Polymer-Based Multivalent Inhibitors Open
Cholera is a potentially fatal bacterial infection that affects a large number of people in developing countries. It is caused by the cholera toxin (CT), an AB5 toxin secreted by Vibrio cholera. The toxin comprises a toxic A-subunit and a …
View article: Exploring Rigid and Flexible Core Trivalent Sialosides for Influenza Virus Inhibition
Exploring Rigid and Flexible Core Trivalent Sialosides for Influenza Virus Inhibition Open
Herein, the chemical synthesis and binding analysis of functionalizable rigid and flexible core trivalent sialosides bearing oligoethylene glycol (OEG) spacers interacting with spike proteins of influenza A virus (IAV) X31 is described. Al…
View article: Lipase-mediated synthesis of sugar–PEG-based amphiphiles for encapsulation and stabilization of indocyanine green
Lipase-mediated synthesis of sugar–PEG-based amphiphiles for encapsulation and stabilization of indocyanine green Open
Bio-catalytically synthesized sugar–PEG-based copolymers form stable micelles in an aqueous medium. These micelles from amphiphilic copolymer are able to efficiently solubilize and stabilize indocyanine green dye (ICG) under physiological …
View article: Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW
Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW Open
The coupling of peptides to polyglycerol carriers represents an important route towards the multivalent display of protein ligands. In particular, the inhibition of low affinity intracellular protein–protein interactions can be addressed b…
View article: Potential of acylated peptides to target the influenza A virus
Potential of acylated peptides to target the influenza A virus Open
For antiviral drug design, especially in the field of influenza virus research, potent multivalent inhibitors raise high expectations for combating epidemics and pandemics. Among a large variety of covalent and non-covalent scaffold system…