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View article: From fragmented to integrated: Advancing surface water quality assessment through WQPI in the upper Medjerda River, Northeastern Algeria
From fragmented to integrated: Advancing surface water quality assessment through WQPI in the upper Medjerda River, Northeastern Algeria Open
Assessing water quality in semi-arid river systems under intense anthropogenic pressures presents significant challenges for sustainable management. In this study, we evaluated the surface water quality of the upper Medjerda River in north…
View article: Integration of cocrystal and nanocrystal techniques to ameliorate solubility, topical antioxidant activity and cytotoxicity of curcumin
Integration of cocrystal and nanocrystal techniques to ameliorate solubility, topical antioxidant activity and cytotoxicity of curcumin Open
Curcumin (CUM), a promising nutraceutical, exhibits diverse pharmacological activities such as antioxidant, anti-inflammatory, antitumor and anti-hyperglycemic, but the clinical applications of CUM is restricted by virtue of its scarce aqu…
View article: ROLE OF VAGINAL MISOPROSTOL IN FAVOURABLE AND UNFAVOURABLE CERVIX IN PREGNANCY INDUCED HYPERTENSION
ROLE OF VAGINAL MISOPROSTOL IN FAVOURABLE AND UNFAVOURABLE CERVIX IN PREGNANCY INDUCED HYPERTENSION Open
Background: Pregnancy-induced hypertension (PIH), including preeclampsia and eclampsia, remains a significant contributor to maternal and neonatal morbidity. Timely induction of labor in these patients is crucial for improving outcomes. Mi…
View article: Formulation and Characterization of Curcumin Niosomes: Antioxidant and Cytotoxicity Studies
Formulation and Characterization of Curcumin Niosomes: Antioxidant and Cytotoxicity Studies Open
Curcumin’s applications in the treatment of conditions including osteoarthritis, dementia, malignancies of the pancreas, and malignancies of the intestines have drawn increasing attention. It has several wonderful qualities, including bein…
View article: [Retracted] Design and Characterization of Agarose/HPMC Buccal Films Bearing Ondansetron HCl In Vitro and In Vivo: Enhancement Using Iontophoretic and Chemical Approaches
[Retracted] Design and Characterization of Agarose/HPMC Buccal Films Bearing Ondansetron HCl In Vitro and In Vivo: Enhancement Using Iontophoretic and Chemical Approaches Open
The study was aimed at designing and characterizing the ondansetron hydrochloride (OND) bearing agarose (AG), and hydroxypropyl methyl cellulose (HPMC) mucoadhesive buccal films employing glycerol as a plasticizer. The buccal delivery of o…
View article: RISK FACTORS AND MANAGEMENT OF PREGNANCY ANEMIA
RISK FACTORS AND MANAGEMENT OF PREGNANCY ANEMIA Open
Background: Pregnancy anemia is global health problem characterized as decrease in the total red blood cells or hemoglobin in the blood during pregnancy. It is more prevalent among developing countries and may lead to maternal and fetal mo…
View article: Quantification of carbon dioxide released from effervescent granules as a predictor of formulation quality using modified Chittick apparatus
Quantification of carbon dioxide released from effervescent granules as a predictor of formulation quality using modified Chittick apparatus Open
Purpose: To develop a method for the measurement of carbon dioxide (CO2) released from effervescent formulations.
Methods: Effervescent granules were prepared using sodium bicarbonate and citric acid by fusion and solvent-assisted granula…
View article: Microneedle based transcutaneous delivery of low molecular weight heparin.
Microneedle based transcutaneous delivery of low molecular weight heparin. Open
This study aimed to fabricate and characterize polymeric microneedle patches for rapid and non-invasive administration of enoxaparin across skin layers. The patches comprising of PVA, sorbitol and enoxaparin sodium were prepared by employi…
View article: Solubility and dissolution rate enhancement of ibuprofen by cyclodextrin based carbonate nanosponges.
Solubility and dissolution rate enhancement of ibuprofen by cyclodextrin based carbonate nanosponges. Open
In the present study nanotechnology approach, i.e., a cyclodextrin (CD) based carbonate nanosponge was used to improve the solubility and dissolution of ibuprofen. Solvent and ultrasound assisted methods were used to prepare nanosponges us…
View article: Formulation and Evaluation of a Clove Oil-Encapsulated Nanofiber Formulation for Effective Wound-Healing
Formulation and Evaluation of a Clove Oil-Encapsulated Nanofiber Formulation for Effective Wound-Healing Open
Wound-healing is complicated process that is affected by many factors, especially bacterial infiltration at the site and not only the need for the regeneration of damaged tissues but also the requirement for antibacterial, anti-inflammator…
View article: DEVELOPMENT AND CHARACTERIZATION OF TASTE MASKED ORODISPERSIBLE FILM OF CHLORPROMAZINE HYDROCHLORIDE
DEVELOPMENT AND CHARACTERIZATION OF TASTE MASKED ORODISPERSIBLE FILM OF CHLORPROMAZINE HYDROCHLORIDE Open
Thin-film drug delivery, also referred to as orodispersible film has emerged as an advanced alternative to the traditional tablets, capsules, and liquids.The present work investigates the improvement in solubility to have a rapid onset of …
View article: DEVELOPMENT OF A VALIDATED METHOD FOR SIMULTANEOUS QUANTIFICATION OF CLARITHROMYCIN AND LEVOFLOXACIN BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-DIODE ARRAY DETECTOR
DEVELOPMENT OF A VALIDATED METHOD FOR SIMULTANEOUS QUANTIFICATION OF CLARITHROMYCIN AND LEVOFLOXACIN BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY-DIODE ARRAY DETECTOR Open
This study aims at the development of a validated reverse phase-high performance liquid chromatography (RP-HPLC) method for the simultaneous quantification of levofloxacin (LVX) and clarithromycin (CAM).Eclipse X DB C18 column (5 µm, 4.6 ×…
View article: Improved Dissolution Rate of Oxcarbazepine by Centrifugal Spinning: In-Vitro and In-Vivo Implications
Improved Dissolution Rate of Oxcarbazepine by Centrifugal Spinning: In-Vitro and In-Vivo Implications Open
Low dissolution rates of poorly soluble drugs are the factor afflicting their bioavailability. The aim of this study is to prepare a centrifugal spinning-based formulation of a poorly soluble drug, oxcarbazepine, for the improvement of dis…
View article: PREVELANCE OF METFORMIN-INDUCED GASTROINTESTINAL PROBLEMS
PREVELANCE OF METFORMIN-INDUCED GASTROINTESTINAL PROBLEMS Open
Metformin is used as an anti-diabetic medicine among oral hypoglycemic drugs, which produces many gastrointestinal problems.This study aims to investigate the effect of metformin-induced gastrointestinal problems and its prevalence.The cro…
View article: Nanosponge-based hydrogel preparation of fluconazole for improved topical delivery
Nanosponge-based hydrogel preparation of fluconazole for improved topical delivery Open
Purpose: To develop polymeric nanosponge based hydrogel system of fluconazole (FZ) for improved delivery for topical application.Method: Six different nanosponge preparations of fluconazole were formulated by oil-in-water (o/w) emulsion so…
View article: Taste Masking of Levofloxacin by Microparticulate System Using Emulsion Solvent Evaporation Technique
Taste Masking of Levofloxacin by Microparticulate System Using Emulsion Solvent Evaporation Technique Open
The preparation of microspheres by emulsion solvent evaporation technique has become an area of considerable attention in pharmaceutical industry. In the present study, investigation reports the formulation of microspheres of levofloxacin …
View article: Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen
Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen Open
Purpose: To develop and evaluate nanosponge (NS) based sustained release formulations of naproxen (NAP) and ibuprofen (IBU).Method: Six formulations of each candidate drug were prepared by emulsion solvent diffusion method, using varying r…
View article: Development of paracetamol-caffeine co-crystals to improve compressional, formulation and <i>in vivo</i> performance
Development of paracetamol-caffeine co-crystals to improve compressional, formulation and <i>in vivo</i> performance Open
Paracetamol, a frequently used antipyretic and analgesic drug, has poor compression moldability owing to its low plasticity. In this study, new co-crystals of paracetamol (PCM) with caffeine (as a co-former) were prepared and delineated. C…