Sumiko Abe
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View article: Physiological significance of amino acid recycling from vacuoles under starvation conditions
Physiological significance of amino acid recycling from vacuoles under starvation conditions Open
Avt6 is a transporter that exports acidic amino acids, such as aspartate and glutamate. We found that disrupting AVT6 in cells lacking other vacuolar amino acid exporters, including Avt3, Avt4, and Avt7, increased vacuolar neutral amino ac…
View article: Functional embeddings enable Aggregation of multi-area SEEG recordings over subjects and sessions
Functional embeddings enable Aggregation of multi-area SEEG recordings over subjects and sessions Open
Aggregating intracranial recordings across subjects is challenging since electrode count, placement, and covered regions vary widely. Spatial normalization methods like MNI coordinates offer a shared anatomical reference, but often fail to…
View article: Optimized DBS in pediatric dystonia restores balance in transmission of signals within pallidothalamic network by modulating neural oscillations in deep brain regions
Optimized DBS in pediatric dystonia restores balance in transmission of signals within pallidothalamic network by modulating neural oscillations in deep brain regions Open
Deep brain stimulation (DBS) is a neuromodulation technique commonly used for treatment of movement disorders, including dystonia. Stimulation of the globus pallidus internus (GPi) of basal ganglia or the subthalamic nucleus (STN) typicall…
View article: Frequency-dependent modulation of evoked potentials during GPi-DBS in pediatric dystonia
Frequency-dependent modulation of evoked potentials during GPi-DBS in pediatric dystonia Open
View article: Mapping of Brain Connectivity in Dystonia: Integrating of Electrophysiology and Advanced Imaging Techniques
Mapping of Brain Connectivity in Dystonia: Integrating of Electrophysiology and Advanced Imaging Techniques Open
View article: Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes
Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes Open
Diffuse interstitial lung diseases (ILD) include conditions with identifiable causes such as chronic eosinophilic pneumonia (CEP), sarcoidosis (SAR), chronic hypersensitivity pneumonitis (CHP), and connective tissue disease-associated inte…
View article: Local field potential signal transmission is correlated with the fractional anisotropy measured by diffusion tractography
Local field potential signal transmission is correlated with the fractional anisotropy measured by diffusion tractography Open
In this paper we aim to examine the correlation between diffusion tensor imaging parameters of anatomical connectivity and characteristics of signal transmission obtained from patient-specific transfer function models. Here, we focused on …
View article: Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment
Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment Open
These findings suggest a suppression of both type 2 and non-type 2 inflammation in response to benralizumab treatment, with potential implications for asthma management. However, the limitations of the study include a small sample size and…
View article: Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period
Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period Open
In this retrospective study the GETE after 2 years of omalizumab therapy emerged as the most meaningful predictor of the long-term effectiveness of omalizumab treatment in patients with severe asthma, highlighting the benefits of prolonged…
View article: Co-Stimulation with TWEAK and TGF-β1 Induces Steroid-Insensitive TSLP and CCL5 Production in BEAS-2B Human Bronchial Epithelial Cells
Co-Stimulation with TWEAK and TGF-β1 Induces Steroid-Insensitive TSLP and CCL5 Production in BEAS-2B Human Bronchial Epithelial Cells Open
Steroid-resistant asthma is a common cause of refractory asthma. Type 2 inflammation is the main inflammatory response in asthma, and the mechanism underlying the steroid-resistance of type 2 inflammation has not been completely elucidated…
View article: Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients
Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients Open
The analysis of skin surface lipid-RNAs (SSL-RNAs) provides a non-invasive method for understanding the molecular pathology of atopic dermatitis (AD), but its relevance to asthma remains uncertain. Although dupilumab, a biologic drug appro…
View article: Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma
Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma Open
Type-2 biomarkers may act as indicators of improvement in FEV1 and sputum outcomes among patients with severe asthma undergoing dupilumab treatment in real-world settings.
View article: Local field potential signal transmission is correlated with the fractional anisotropy measured by diffusion tractography
Local field potential signal transmission is correlated with the fractional anisotropy measured by diffusion tractography Open
Objective In this paper we aim to examine the correlation between diffusion tensor imaging (DTI) parameters of anatomical connectivity and characteristics of signal transmission obtained from patient-specific transfer function models. Here…
View article: Diffusion tractography predicts Deep Brain Stimulation evoked potential amplitude and delay
Diffusion tractography predicts Deep Brain Stimulation evoked potential amplitude and delay Open
Objective This study investigated the relationship between DBS evoked potentials (EPs) and diffusion tensor imaging (DTI) in a group of patients with dystonia who underwent DBS treatment. EPs and DTI are both useful methods for studying ne…
View article: Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma
Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma Open
This study has limitations, including its single-arm observational design and the small sample size. However, BT led to a symptomatic improvement in patients with severe asthma. The validated "√WA at Pi10" metric on CT effectively evaluate…
View article: Globus pallidus internus activity increases during voluntary movement in children with dystonia
Globus pallidus internus activity increases during voluntary movement in children with dystonia Open
The rate model of basal ganglia function predicts that muscle activity in dystonia is due to disinhibition of thalamus resulting from decreased inhibitory input from pallidum. We seek to test this hypothesis in children with dyskinetic cer…
View article: Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma
Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma Open
Benralizumab treatment reduces exacerbations and improves symptom control and quality of life in patients with severe eosinophilic asthma. However, the determination of biomarkers that predict therapeutic effectiveness is required for prec…
View article: Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen
Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen Open
Allergen immunotherapy is a promising treatment for allergic diseases that induce immune tolerance through the administration of specific allergens. In this study, we investigate the efficacy of sublingual immunotherapy (SLIT) in asthmatic…
View article: P9‐18: Effects of one‐year of dupilumab treatment in patients with severe asthma
P9‐18: Effects of one‐year of dupilumab treatment in patients with severe asthma Open
growth in FEV 1 and FEF 25-75 and greater decline in FVC when compared with males.Age at baseline, body mass index and inhaled corticosteroid treatment ever also affected patients' lung function growth.
View article: A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction
A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction Open
Background Although Japanese radish ( Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish. Case presentation A 48-year-old woman developed urticarial …
View article: THE EVIL UNLEASHED FROM PANDORA'S BOX: PANDORAEA APISTA COLONIZATION IN A PATIENT WITH LUNG ADENOCARCINOMA
THE EVIL UNLEASHED FROM PANDORA'S BOX: PANDORAEA APISTA COLONIZATION IN A PATIENT WITH LUNG ADENOCARCINOMA Open
Background and Aims: Sepsis is a frequent fatal complication of pneumonia.The quickSOFA score (qSOFA) is mortality predictor in critical patients.The Hour-1 bundle is recommended as the first reference for sepsis determination which is ser…
View article: Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data
Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data Open
This is a release of the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data. ERuDIte contains over 11,000 training resources on data science including courses (MOO…
View article: Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data
Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data Open
This is a release of the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data. ERuDIte contains over 11,000 training resources on data science including courses (MOO…
View article: Advancing the international data science workforce through shared training and education
Advancing the international data science workforce through shared training and education Open
The increasing richness and diversity of biomedical data types creates major organizational and analytical impediments to rapid translational impact in the context of training and education. As biomedical data-sets increase in size, variet…
View article: Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data
Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data Open
This is a release of the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data. ERuDIte contains over 11,000 training resources on data science including courses (MOO…
View article: Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma
Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma Open
Zinc plays a pivotal role in various zinc enzymes, which are crucial in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver fibrosis prog…
View article: Support Vector Machines, Multidimensional Scaling and Magnetic Resonance Imaging Reveal Structural Brain Abnormalities Associated With the Interaction Between Autism Spectrum Disorder and Sex
Support Vector Machines, Multidimensional Scaling and Magnetic Resonance Imaging Reveal Structural Brain Abnormalities Associated With the Interaction Between Autism Spectrum Disorder and Sex Open
Despite substantial efforts, it remains difficult to identify reliable neuroanatomic biomarkers of autism spectrum disorder (ASD) based on magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Studies which use standard stat…
View article: Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma
Long-Term Zinc Supplementation Improves Liver Function and Decreases the Risk of Developing Hepatocellular Carcinoma Open
Background and Aim: Zinc plays a pivotal role in various zinc enzymes, resulting in the maintenance of liver function. Patients with chronic liver diseases (CLDs) usually have lower concentrations of zinc, which decrease further as liver f…
View article: Big Data To Knowledge (Bd2K) Training Coordinating Center (Tcc) Educational Resource Discovery Index (Erudite) As Linked Data
Big Data To Knowledge (Bd2K) Training Coordinating Center (Tcc) Educational Resource Discovery Index (Erudite) As Linked Data Open
This is a release of the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data. ERuDIte contains over 10,000 training resources on data science including courses (MOO…
View article: Big Data To Knowledge (Bd2K) Training Coordinating Center (Tcc) Educational Resource Discovery Index (Erudite) As Linked Data
Big Data To Knowledge (Bd2K) Training Coordinating Center (Tcc) Educational Resource Discovery Index (Erudite) As Linked Data Open
This is a release of the Big Data to Knowledge (BD2K) Training Coordinating Center (TCC) Educational Resource Discovery Index (ERuDIte) as Linked Data. ERuDIte contains over 10,000 training resources on data science including courses (MOO…