Sumin Han
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View article: Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer
Identification and Characterization of PLUTO-201, a Novel Long Non-Coding RNA Associated with Poor Outcomes in Prostate Cancer Open
Despite extensive investigation, the factors promoting aggressive prostate cancer are poorly understood. By performing a comprehensive analysis of whole-genome transcriptome data to identify differential expression across 1,567 patients wi…
View article: Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease
Adherence to Pharmacological Management Guidelines for Stable Chronic Obstructive Lung Disease Open
Background: This study evaluated adherence to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and Korean guidelines in the prescription patterns of respiratory specialists for stable chronic obstructive pulmonary disease …
View article: Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases
Gintonin-Enriched Panax ginseng Extract Induces Apoptosis in Human Melanoma Cells by Causing Cell Cycle Arrest and Activating Caspases Open
Gintonin, a non-saponin glycolipoprotein from Panax ginseng, acts as a lysophosphatidic acid ligand. However, its anticancer effects, especially in melanoma, remain unclear. This study investigated the anti-proliferative effects and intrac…
View article: Gintonin-Enriched Panax ginseng Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis through DR4/5 Upregulation
Gintonin-Enriched Panax ginseng Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis through DR4/5 Upregulation Open
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising chemotherapeutic agent because of its selective apoptotic action on cancer cells. However, resistance to TRAIL-induced apoptosis remains a challenge in many can…
View article: A systematic approach for learning imbalanced data: enhancing zero-inflated models through boosting
A systematic approach for learning imbalanced data: enhancing zero-inflated models through boosting Open
In this paper, we propose systematic approaches for learning imbalanced data based on a two-regime process: regime 0, which generates excess zeros (majority class), and regime 1, which contributes to generating an outcome of one (minority …
View article: Gintonin-Enriched <em>Panax ginseng</em> Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-induced Apoptosis through DR4/5 Upregulation
Gintonin-Enriched <em>Panax ginseng</em> Extract Fraction Sensitizes Renal Carcinoma Cells to TRAIL-induced Apoptosis through DR4/5 Upregulation Open
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising chemotherapeutic agent because of its selective apoptotic action on cancer cells. However, resistance to TRAIL-induced apoptosis remains a challenge in many can…
View article: Data from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Data from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Alterations in DNA repair promote tumor development, but the impact on tumor progression is poorly understood. Here, discovery of a biochemical circuit linking hormone signaling to DNA repair and therapeutic resistance is reported. Finding…
View article: Supplementary Figure 3,4 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Supplementary Figure 3,4 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Supplementary Figure 3,4 - PDF file 443K, Supplemental data demonstrating that exposure to IR promotes cell cycle arrest and AR activity regulates genes required for DNA damage repair
View article: Supplementary Materials and Methods from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers
Supplementary Materials and Methods from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers Open
Materials and Methods for Supplemental experiments
View article: Supplementary Figure 1,2 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Supplementary Figure 1,2 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Supplementary Figure 1,2 - PDF file 56K, Supplemental data demonstrating that scheduling of IR and ADT treatment does not alter cell survival and DNA damage induces AR mediated gene transcription in a dose dependent fashion
View article: Supplementary Methods from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Supplementary Methods from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Supplementary Methods - PDF file 79K, Additional materials and methods not described in main manuscript
View article: Supplementary Figures 1-9 from Dual Roles of PARP-1 Promote Cancer Growth and Progression
Supplementary Figures 1-9 from Dual Roles of PARP-1 Promote Cancer Growth and Progression Open
PDF file - 410K, Dose responses, transcriptional, biological, biochemical, and in vivo supplemental data
View article: Supplementary Figure 5,6 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Supplementary Figure 5,6 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Supplementary Figure 5,6 - PDF file 143K, Supplemental data demonstrating that DNAPKcs knockdown is maintained in growth studies and ATM expression and activity is regulated by DNAPKcs knockdown and inhibition
View article: Supplementary Tables 1-3 from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers
Supplementary Tables 1-3 from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers Open
Supplementary Table 1. Primers and Oligos Sequences Supplementary Table 2. shRNA and siRNA Sequences Supplementary Table 3. Antibody list
View article: Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer Open
Supplementary Figure 4. Overlap of positive and negative correlations.
View article: Data from Dual Roles of PARP-1 Promote Cancer Growth and Progression
Data from Dual Roles of PARP-1 Promote Cancer Growth and Progression Open
PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair and also functions as a context-specific regulator of transcription factors. With multiple …
View article: Supplementary Figures 1-5 from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers
Supplementary Figures 1-5 from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers Open
Figure S1. Validation of Project Achilles data, evaluation of TPRKB expression profile across human tissues and ability to knock down TPRKB across cell lines. Figure S2. Cell lines with different types of TP53 alterations show dramatic red…
View article: Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer Open
Supplementary Figure 3. Expression of PCAT29 in VCaP and LNCaP cells.
View article: Supplementary Materials and Methods from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers
Supplementary Materials and Methods from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers Open
Materials and Methods for Supplemental experiments
View article: Data from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer
Data from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer Open
Long noncoding RNAs (lncRNA) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay between known oncogenic or tumor-suppressive events and lncRNAs has not been wel…
View article: Supplementary Figure 5,6 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Supplementary Figure 5,6 from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Supplementary Figure 5,6 - PDF file 143K, Supplemental data demonstrating that DNAPKcs knockdown is maintained in growth studies and ATM expression and activity is regulated by DNAPKcs knockdown and inhibition
View article: Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer Open
Supplementary Figure 4. Overlap of positive and negative correlations.
View article: Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer Open
Supplementary Table S2. Positive and negative correlations.
View article: Supplementary Methods , Table 1 from Dual Roles of PARP-1 Promote Cancer Growth and Progression
Supplementary Methods , Table 1 from Dual Roles of PARP-1 Promote Cancer Growth and Progression Open
PDF file - 91K
View article: Supplementary Methods from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult
Supplementary Methods from A Hormone–DNA Repair Circuit Governs the Response to Genotoxic Insult Open
Supplementary Methods - PDF file 79K, Additional materials and methods not described in main manuscript
View article: Supplementary Figures 1-5 from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers
Supplementary Figures 1-5 from Identification of TP53RK-Binding Protein (TPRKB) Dependency in <i>TP53</i>-Deficient Cancers Open
Figure S1. Validation of Project Achilles data, evaluation of TPRKB expression profile across human tissues and ability to knock down TPRKB across cell lines. Figure S2. Cell lines with different types of TP53 alterations show dramatic red…
View article: Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer
Data Supplement from The lncRNA <i>PCAT29</i> Inhibits Oncogenic Phenotypes in Prostate Cancer Open
Supplementary Figure 2. Expression of PCAT29 in LNCaP cells.