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View article: Evaluation of a creatinine clearance correction equation based on body fat mass in older Japanese patients with diabetes
Evaluation of a creatinine clearance correction equation based on body fat mass in older Japanese patients with diabetes Open
Background The estimation of creatinine clearance (CCr) in older adult patients with diabetes is subject to deviations from the results of actual measurements because of changes in body composition. In the present study, we aimed to create…
View article: Correction to: Clinical questions and good practice statements of clinical practice guidelines for management of kidney injury during anticancer drug therapy 2022
Correction to: Clinical questions and good practice statements of clinical practice guidelines for management of kidney injury during anticancer drug therapy 2022 Open
View article: Clinical questions and good practice statements of clinical practice guidelines for management of kidney injury during anticancer drug therapy 2022
Clinical questions and good practice statements of clinical practice guidelines for management of kidney injury during anticancer drug therapy 2022 Open
Background Burn patients often face a high risk of acute kidney injury (AKI) after severe burn injuries, meanwhile epigallocatechin-3-gallate (EGCG) has been proven to be effective in alleviating organ injury.Methods This study used the cl…
View article: Correction to: Awareness and current implementation of drug dosage adjustment by pharmacists in patients with chronic kidney disease in Japan: a web-based survey
Correction to: Awareness and current implementation of drug dosage adjustment by pharmacists in patients with chronic kidney disease in Japan: a web-based survey Open
View article: Supplementary Material for: Improved Formula for Predicting Hemodialyzability of Intravenous and Oral Drugs
Supplementary Material for: Improved Formula for Predicting Hemodialyzability of Intravenous and Oral Drugs Open
Background: The rate of drug removal by hemodialysis needs to be considered when designing drug dosage regimens for patients on hemodialysis. We previously developed a simplified equation to predict the removal rates of intra…
View article: In vivo evaluation of drug dialyzability in a rat model of hemodialysis
In vivo evaluation of drug dialyzability in a rat model of hemodialysis Open
It is important to calculate the drug removal by hemodialysis (HD) for drug dosing regimens in HD patients. However, there are limited and inconsistent information about the dialyzability of drugs by HD. Therefore, the aim of our study is …
View article: Adolescent with Acute Eosinophilic Pneumonia with Acute Respiratory Failure Associated with Multifactorial Inhalational Substance Use
Adolescent with Acute Eosinophilic Pneumonia with Acute Respiratory Failure Associated with Multifactorial Inhalational Substance Use Open
View article: Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model
Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model Open
Patients on dialysis are frequently administered high doses of potassium binders such as calcium polystyrene sulfonate (CPS) and sodium polystyrene sulfonate (SPS), which exacerbate constipation. Here, we compare the degree of constipation…
View article: Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity
Edoxaban Exerts Antioxidant Effects Through FXa Inhibition and Direct Radical-Scavenging Activity Open
The interplay between oxidative stress, inflammation, and tissue fibrosis leads to the progression of chronic kidney disease (CKD). Edoxaban, an activated blood coagulation factor Xa (FXa) inhibitor, ameliorates kidney disease by suppressi…
View article: SUN-159 RENAL PROTECTIVE EFFECT OF LACTULOSE TARGETING OF GUT-KIDNEY AXIS
SUN-159 RENAL PROTECTIVE EFFECT OF LACTULOSE TARGETING OF GUT-KIDNEY AXIS Open
With the dramatic development of microbiome research in the last decades, gut-kidney axis which is interaction between intestinal environment and kidney has drawn attention, and it was reported that lubiprostone, a novel laxative, improved…
View article: SUN-153 ACCUMULATION OF ACETAMINOPHEN METABOLITES EXERTS KIDNEY PROTECTIVE EFFECT IN RENAL FAILURE RAT MODEL
SUN-153 ACCUMULATION OF ACETAMINOPHEN METABOLITES EXERTS KIDNEY PROTECTIVE EFFECT IN RENAL FAILURE RAT MODEL Open
Acetaminophen (APAP) is recommended preferential use in pain management of chronic kidney disease (CKD) patients owing to fewer side effects in clinical dose. Although it is highly safe drug, usefulness of APAP is not consistent during lon…
View article: Coefficient of Determination between Estimated and Measured Renal Function in Japanese Patients with Sarcopenia May Be Improved by Adjusting for Muscle Mass and Sex: A Prospective Study
Coefficient of Determination between Estimated and Measured Renal Function in Japanese Patients with Sarcopenia May Be Improved by Adjusting for Muscle Mass and Sex: A Prospective Study Open
Creatinine (Cr) levels are strongly affected by muscle mass, and the estimated glomerular filtration rate (eGFR), a measure based on serum creatinine (SCr), is often overestimated in patients with sarcopenia. To evaluate the coefficient of…
View article: Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats
Effects of lactulose on renal function and gut microbiota in adenine-induced chronic kidney disease rats Open
View article: Knowledge and awareness of nonpharmacist salespersons regarding over-the-counter drug use in patients with chronic kidney disease in Japan
Knowledge and awareness of nonpharmacist salespersons regarding over-the-counter drug use in patients with chronic kidney disease in Japan Open
The results indicate that before the intervention, the registered salespersons had low levels of awareness and knowledge regarding OTC drug use in patients with CKD despite having prior experience selling unsuitable OTC drugs. However, the…
View article: Medication Management for the Patients with Chronic Kidney Disease by Collaboration of Pharmacists and Physicians
Medication Management for the Patients with Chronic Kidney Disease by Collaboration of Pharmacists and Physicians Open
診断し，処方箋を書く医師は，薬物動態・相互作用について必ずしも得意なわけではない．それを補うためには，これからの薬剤師は「調剤し服薬指導をする人」から「薬物適正使用を推進する人」に変わっていく必要がある．それによって，①腎機能低下患者の中毒性副作用の未然防止，②適切な服薬指導による腎機能悪化・心血管合併症の防止，③腎毒性薬物による薬剤性腎障害の防止について，医師との緊密な協力によって成し遂げなければならない．
View article: Benzbromarone Attenuates Oxidative Stress in Angiotensin II‐ and Salt‐Induced Hypertensive Model Rats
Benzbromarone Attenuates Oxidative Stress in Angiotensin II‐ and Salt‐Induced Hypertensive Model Rats Open
Oxidative stress induced by hyperuricemia is closely associated with the renin‐angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce o…
View article: Guidelines for Therapeutic Drug Monitoring of Cardiovascular Drugs Clinical Use of Blood Drug Concentration Monitoring (JCS 2015) ― Digest Version ―
Guidelines for Therapeutic Drug Monitoring of Cardiovascular Drugs Clinical Use of Blood Drug Concentration Monitoring (JCS 2015) ― Digest Version ― Open
CQ2 Does blood drug concentration monitoring of antiarrhythmic drugs help reduce ADRs in patients with arrhythmia who are receiving antiarrhythmic drugs?.............. 588 CQ3 Can we shorten the time to achieve an optimal dosage regimen by…
View article: Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version
Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version Open
View article: Interaction of arbekacin with dialysis membrane
Interaction of arbekacin with dialysis membrane Open
The interaction between arbekacin and the hemodialysis membrane is unclear. The aim of this study was to evaluate the adsorption of arbekacin (ABK) onto hemodialysis membranes and to establish a simpler system for evaluating the adsorption…
View article: Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model
Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model Open
View article: Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial
Effects of Nutritional Supplementation on Fatigue, and Autonomic and Immune Dysfunction in Patients with End-Stage Renal Disease: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial Open
Nutritional supplementation may modulate immune and autonomic dysfunction in ESRD patients undergoing hemodialysis.
View article: Community-Pharmacy based Trials for Drug Dose Adjustment in which Pharmacists Evaluate Renal Function
Community-Pharmacy based Trials for Drug Dose Adjustment in which Pharmacists Evaluate Renal Function Open
In patients with chronic kidney disease (CKD), cautious drug dose adjustment is required as adverse effects including drug-induced acute kidney injury or drug intoxication may occur when an inappropriate dose of medicine is administered. W…
View article: High incidence of adverse events in patients with impaired renal function taking pregabalin, even when dose is adjusted for renal function
High incidence of adverse events in patients with impaired renal function taking pregabalin, even when dose is adjusted for renal function Open
プレガバリン (リリカ®) は尿中排泄率約90%と腎排泄性薬物であり腎機能に応じた用量調節を行い安全に使用することが臨床現場での課題となっている. 光晴会病院では, 添付文書での推奨投与量以下の用量での有害事象発生状況について調査を行った. 調査期間は2010年6月~2013年11月で120名のうち, 14名でめまい・嗜眠などの中枢神経系有害事象が発生した. 多くは投与開始後6日以内にみられ, 有害事象発生群の体重は非発生群に比し, 有意に低かった (p=0.005). 腎…
View article: Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment
Direct Radical Scavenging Activity of Benzbromarone Provides Beneficial Antioxidant Properties for Hyperuricemia Treatment Open
Uric acid exerts an important antioxidant effect against external oxidative stress under physiological conditions. However, uric acid itself can increase oxidative stress via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxid…