Sumit K. Chanda
YOU?
Author Swipe
View article: Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design
Covalent Probes Reveal Small-Molecule Binding Pockets in Structured RNA and Enable Bioactive Compound Design Open
The SARS-CoV-2 frameshift stimulation element (FSE) is a critical RNA structure that is essential for viral replication and represents a promising target for antiviral intervention. Here, Chemical Cross-Linking and Isolation by Pull-down (…
View article: Integrative multi-omics analysis in vivo identifies influenza virus host factors
Integrative multi-omics analysis in vivo identifies influenza virus host factors Open
View article: Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection
Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection Open
Defining the subset of cellular factors governing SARS-CoV-2 replication can provide critical insights into viral pathogenesis and identify targets for host-directed antiviral therapies. While a number of genetic screens have previously re…
View article: Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex
Corrigendum: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex Open
[This corrects the article DOI: 10.3389/fphar.2022.1029093.].
View article: Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread
Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread Open
SARS-CoV-2 initiates infection in the conducting airways, where mucociliary clearance inhibits pathogen penetration. However, it is unclear how mucociliary clearance impacts SARS-CoV-2 spread after infection is established. To investigate …
View article: Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA
Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA Open
View article: Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle Replication
Global siRNA Screen Reveals Critical Human Host Factors of SARS-CoV-2 Multicycle Replication Open
Defining the subset of cellular factors governing SARS-CoV-2 replication can provide critical insights into viral pathogenesis and identify targets for host-directed antiviral therapies. While a number of genetic screens have previously re…
View article: Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing Open
View article: Drug target prediction through deep learning functional representation of gene signatures
Drug target prediction through deep learning functional representation of gene signatures Open
Many machine learning applications in bioinformatics currently rely on matching gene identities when analyzing input gene signatures and fail to take advantage of preexisting knowledge about gene functions. To further enable comparative an…
View article: Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice
Molecular Determinants of PQBP1 Binding to the HIV-1 Capsid Lattice Open
Human immunodeficiency virus type 1 (HIV-1) stimulates innate immune responses upon infection, including cyclic GMP-AMP synthase (cGAS) signaling that results in type I interferon production. HIV-1-induced activation of cGAS requires the h…
View article: Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure
Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure Open
Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing t…
View article: The Therapeutic Monoclonal Antibody Bamlanivimab Does Not Enhance SARS-CoV-2 Infection by FcR-Mediated Mechanisms
The Therapeutic Monoclonal Antibody Bamlanivimab Does Not Enhance SARS-CoV-2 Infection by FcR-Mediated Mechanisms Open
As part of the non-clinical safety package characterizing bamlanivimab (SARS-CoV-2 neutralizing monoclonal antibody), the risk profile for antibody-dependent enhancement of infection (ADE) was evaluated in vitro and in an African green mon…
View article: Drug target prediction through deep learning functional representation of gene signatures
Drug target prediction through deep learning functional representation of gene signatures Open
Many machine learning applications in bioinformatics currently rely on gene identities extracted from input gene signatures, and fail to take advantage of preexisting knowledge about gene functions. We developed the Functional Representati…
View article: Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets Open
Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using a…
View article: Live imaging of the airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread
Live imaging of the airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread Open
View article: Identification of global inhibitors of cellular glycosylation
Identification of global inhibitors of cellular glycosylation Open
Small molecule inhibitors of glycosylation enzymes are valuable tools for dissecting glycan functions and potential drug candidates. Screening for inhibitors of glycosyltransferases are mainly performed by in vitro enzyme assays with diffi…
View article: Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2
Activation of the Interferon Pathway in Trophoblast Cells Productively Infected with SARS-CoV-2 Open
SARS-CoV-2 infection during pregnancy has been associated with poor maternal and neonatal outcomes and placental defects. The placenta, which acts as a physical and immunological barrier at the maternal-fetal interface, is not established …
View article: Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex
Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex Open
The translation initiation complex 4F (eIF4F) is a rate-limiting factor in protein synthesis. Alterations in eIF4F activity are linked to several diseases, including cancer and infectious diseases. To this end, coronaviruses require eIF4F …
View article: The therapeutic monoclonal antibody bamlanivimab does not enhance SARS‑CoV-2 infection by FcR-mediated mechanisms
The therapeutic monoclonal antibody bamlanivimab does not enhance SARS‑CoV-2 infection by FcR-mediated mechanisms Open
Background Antibodies targeting envelope glycoproteins have been shown in some instances to enhance infection by subverting Fc receptor and complement function, or by directly inducing fusion with cellular membranes. The potential for anti…
View article: SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir Open
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology foc…
View article: Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans
Common and species-specific molecular signatures, networks, and regulators of influenza virus infection in mice, ferrets, and humans Open
Molecular responses to influenza A virus (IAV) infections vary between mammalian species. To identify conserved and species-specific molecular responses, we perform a comparative study of transcriptomic data derived from blood cells, prima…
View article: Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA
Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA Open
View article: Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity
Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity Open
There is a pressing need for host-directed therapeutics that elicit broad-spectrum antiviral activities to potentially address current and future viral pandemics. Apratoxin S4 (Apra S4) is a potent Sec61 inhibitor that prevents cotranslati…
View article: Synthetic lethality-based prediction of anti-SARS-CoV-2 targets
Synthetic lethality-based prediction of anti-SARS-CoV-2 targets Open
Novel strategies are needed to identify drug targets and treatments for the COVID-19 pandemic. The altered gene expression of virus-infected host cells provides an opportunity to specifically inhibit viral propagation via targeting the syn…
View article: NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes
NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes Open
NFAT activating protein with ITAM motif 1 (NFAM1) is an ITAM bearing-transmembrane receptor that has been reported to play a role in B cell signaling and development. We performed expression analysis of NFAM1 using publicly available gene …
View article: Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection
Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection Open
Ly6C hi inflammatory monocytes show high IFN responses, and contribute to both protective and pathogenic functions following influenza virus infection. In order to understand the significance of IFN responses in this subset, we examined mo…
View article: Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques
Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques Open
Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication o…
View article: A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor
A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor Open
The HIV-1 accessory protein Vpu modulates membrane protein trafficking and degradation to provide evasion of immune surveillance. Targets of Vpu include CD4, HLAs, and BST-2. Several cellular pathways co-opted by Vpu have been identified, …
View article: Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets
Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets Open
Tremendous progress has been made to control the COVID-19 pandemic caused by the SARS-CoV-2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this urgen…
View article: Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy Open