Shresh Pathak
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Effect of betahistine on pro‐inflammatory cytokine expression in autoimmune inner ear disease and Meniere's disease patients Open
Objective Betahistine is a partial H1 receptor agonist and a potent H3 receptor antagonist commonly used for the treatment of MD and peripheral vertigo. The aim of this study was to investigate the impact of betahistine on the salt induced…
Protective Effect of Ethanolic Extract of Lycopodium Clavatum Against Pathogenic Escherichia Coli and Proteus Vulgaris Open
as a Post-Doctoral fellow at CARE from 2016-2018, his work was mainly focused on Lycopodium clavatum, a plant extract used for treating alimentary canal related indigestion and in ammations of urinary organs and dermal problems.His work ai…
Autoimmune inner ear disease patient–associated 28-kDa proinflammatory IL-1β fragment results from caspase-7–mediated cleavage in vitro Open
Interleukin-1β (IL-1β) is a key proinflammatory cytokine involved in the progression of many autoinflammatory and autoimmune diseases, including autoimmune inner ear disease (AIED). IL-1β inhibition has been shown to result in clinical hea…
The Balance of Tissue Inhibitor of Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Autoimmune Inner Ear Disease Patients Open
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is a protein implicated in the control of inflammation in a number of autoimmune diseases. We hypothesized that the balance of TIMP-1 and matrix metalloproteinase-9 (MMP-9) may influence the…
<span>AAO</span> : Autoimmune and Autoinflammatory (Disease) in Otology: What is New in Immune‐Mediated Hearing Loss Open
AIED has clinical features of both autoimmune and autoinflammatory disease. It is critical that autoinflammatory diseases be correctly identified, as failure to do so may result in systemic amyloidosis and kidney damage.