Sumitra Shantakumar
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View article: Burden of herpes zoster in adults by age, sex, and underlying conditions in Taiwan: A retrospective cohort study, 2011–2020
Burden of herpes zoster in adults by age, sex, and underlying conditions in Taiwan: A retrospective cohort study, 2011–2020 Open
The risk of herpes zoster (HZ) and its complications increases with age and is higher in individuals with specific comorbidities. Recent population-level data for HZ disease and health economic burden in Taiwan are limited. We aimed to est…
View article: Herpes zoster vaccination and vaccine preferences among persons aged 50–64 years in Australia: Findings from a discrete choice experiment
Herpes zoster vaccination and vaccine preferences among persons aged 50–64 years in Australia: Findings from a discrete choice experiment Open
Vaccine-preventable herpes zoster (HZ) poses substantial burden among Australian adults ≥50 years of age (YOA) despite available vaccination. This study aimed to understand the HZ vaccine-related preferences of adults paying out-of-pocket …
View article: A systematic review and meta-analysis of herpes zoster risk in adults with immunocompromised conditions and autoimmune diseases in Asia-Pacific
A systematic review and meta-analysis of herpes zoster risk in adults with immunocompromised conditions and autoimmune diseases in Asia-Pacific Open
Asia-Pacific (APAC) faces an increasing burden of herpes zoster (HZ) over time. The risk of HZ and its complications are increased in immunocompromised (IC) patients and those with autoimmune diseases (AID). Our study aimed to synthesize e…
View article: Patient preferences toward herpes zoster vaccination among individuals aged 50 years or older in South Korea: Findings from a discrete choice experiment
Patient preferences toward herpes zoster vaccination among individuals aged 50 years or older in South Korea: Findings from a discrete choice experiment Open
In South Korea, the increasing incidence of herpes zoster (HZ) and aging population warrant consideration of HZ vaccination for older adults. There is a need to understand the HZ vaccine-related preferences of adults aged ≥50 years and adu…
View article: Blood eosinophil count and treatment patterns of chronic obstructive pulmonary disease patients in South Korea using real-world data
Blood eosinophil count and treatment patterns of chronic obstructive pulmonary disease patients in South Korea using real-world data Open
Background/Aims: Chronic obstructive pulmonary disease (COPD) management guidelines have increasingly emphasised the importance of exacerbation prevention, and the role of blood eosinophil count (BEC) as a biomarker for inhaled corticoster…
View article: Burden of Herpes Zoster in Individuals With Chronic Conditions in the Republic of Korea: A Nationwide Population-Based Database Study
Burden of Herpes Zoster in Individuals With Chronic Conditions in the Republic of Korea: A Nationwide Population-Based Database Study Open
Background Chronic conditions (CCs) may increase the risk of herpes zoster (HZ) infection, leading to a greater healthcare burden in these individuals compared to those without CCs. It is therefore clinically important to quantify HZ disea…
View article: A systematic literature review of the epidemiology and burden of herpes zoster in selected locales in Asia Pacific
A systematic literature review of the epidemiology and burden of herpes zoster in selected locales in Asia Pacific Open
Herpes zoster (HZ) is a painful rash which typically affects older adults. This is of concern in Asia-Pacific given its aging population. As HZ epidemiology and burden are evolving, this systematic literature review aimed to update the cur…
View article: Knowledge, attitude, and practice toward herpes zoster (HZ) and HZ vaccination: Concept elicitation findings from a multi-country study in the Asia Pacific
Knowledge, attitude, and practice toward herpes zoster (HZ) and HZ vaccination: Concept elicitation findings from a multi-country study in the Asia Pacific Open
Herpes zoster (HZ) is a prevalent disease characterized by a painful rash. A multi‑country study was conducted to elicit public and physician knowledge, attitude, and practice (KAP) toward HZ disease and vaccination for the assessment of l…
View article: Population-Based Study of Pertussis Incidence and Risk Factors among Persons <u>></u>50 Years of Age, Australia
Population-Based Study of Pertussis Incidence and Risk Factors among Persons >50 Years of Age, Australia Open
Despite vaccination programs, pertussis has been poorly controlled, especially among older adults in Australia. This longitudinal, retrospective, observational study aimed to estimate the incidence and risk factors of pertussis among perso…
View article: BURDEN OF HERPES ZOSTER IN INDIVIDUALS WITH IMMUNOCOMPROMISED CONDITIONS AND AUTOIMMUNE DISEASES IN SOUTH KOREA: A NATIONWIDE POPULATION-BASED DATABASE STUDY
BURDEN OF HERPES ZOSTER IN INDIVIDUALS WITH IMMUNOCOMPROMISED CONDITIONS AND AUTOIMMUNE DISEASES IN SOUTH KOREA: A NATIONWIDE POPULATION-BASED DATABASE STUDY Open
Intro: Individuals with immunocompromised conditions (IC), including autoimmune diseases (AID), are more susceptible to herpes zoster (HZ) and its complications. HZ burden in IC/AID individuals in South Korea has not been fully addressed. …
View article: THE IMPORTANCE OF INCLUDING THE PATIENT VOICE IN HOLISTIC EVIDENCE GENERATION IN ASIA
THE IMPORTANCE OF INCLUDING THE PATIENT VOICE IN HOLISTIC EVIDENCE GENERATION IN ASIA Open
Intro: Generation of patient-centric evidence is suboptimal in Asia. We reflect on evidence generation to support unmet patient needs regarding preventative options for herpes zoster (HZ) in five Asian countries (2020–2022). Across these c…
View article: Incidence and Healthcare Burden of Pertussis among Older Adults with and without Pre-Existing Chronic Obstructive Pulmonary Disease or Asthma in South Korea
Incidence and Healthcare Burden of Pertussis among Older Adults with and without Pre-Existing Chronic Obstructive Pulmonary Disease or Asthma in South Korea Open
A retrospective cohort study was conducted to examine trends in the incidence and burden of pertussis among adults ≥50 years in South Korea, with/without pre-existing chronic obstructive pulmonary disease (COPD) or asthma. The nationwide H…
View article: Development of a real-world database for asthma and COPD: The SingHealth-Duke-NUS-GSK COPD and Asthma Real-World Evidence (SDG-CARE) collaboration
Development of a real-world database for asthma and COPD: The SingHealth-Duke-NUS-GSK COPD and Asthma Real-World Evidence (SDG-CARE) collaboration Open
Purpose The SingHealth-Duke-GlaxoSmithKline COPD and Asthma Real-world Evidence (SDG-CARE) collaboration was formed to accelerate the use of Singaporean real-world evidence in research and clinical care. A centerpiece of the collaboration …
View article: Risk Factors of Pertussis Among Older Adults in South Korea: A Nationwide Health Data-Based Case–Control Study
Risk Factors of Pertussis Among Older Adults in South Korea: A Nationwide Health Data-Based Case–Control Study Open
The above graphical abstract represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-revie…
View article: Treatment patterns and cost of exacerbations in patients with chronic obstructive pulmonary disease using multiple inhaler triple therapy in South Korea
Treatment patterns and cost of exacerbations in patients with chronic obstructive pulmonary disease using multiple inhaler triple therapy in South Korea Open
Background Multiple inhaler triple therapy (MITT), comprising inhaled corticosteroids (ICS), long-acting beta-agonists (LABA), and long-acting muscarinic antagonists (LAMA), has been used as an escalation treatment for patients with chroni…
View article: Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study
Long-Term Effectiveness and Safety of Dutasteride versus Finasteride in Patients with Male Androgenic Alopecia in South Korea: A Multicentre Chart Review Study Open
Dutasteride showed greater effectiveness than finasteride in improving BASP classification in treating male AGA and had a similar or possibly lower occurrence of overall AEs. Dutasteride may provide an effective and safe treatment option f…
View article: Real-world Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Newly Treated Korean Patients With Asthma: A Retrospective Cohort Study
Real-world Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Newly Treated Korean Patients With Asthma: A Retrospective Cohort Study Open
Despite current asthma guidelines, more patients in South Korea were prescribed oral than inhaled medications, resulting in suboptimal asthma management and increased HRU. This study highlights the need to reduce oral corticosteroid prescr…
View article: Burden of illness in blood eosinophilic phenotype COPD patients in New Zealand
Burden of illness in blood eosinophilic phenotype COPD patients in New Zealand Open
Asthma was a common COPD comorbidity in NZ, particularly in Māori/Pacific patients. No overall relationship was observed between BEC/COPD exacerbations, which may reflect background ICS confounding. However, analyses in non-ICS treated par…
View article: Long-Acting Bronchodilator Use in Chronic Obstructive Pulmonary Disease in Primary Care in New Zealand: A Retrospective Study of Treatment Patterns and Evolution Using the HealthStat Database
Long-Acting Bronchodilator Use in Chronic Obstructive Pulmonary Disease in Primary Care in New Zealand: A Retrospective Study of Treatment Patterns and Evolution Using the HealthStat Database Open
Predominant use of ICS/LABA (05/2015 to 04/2016) reflects available LABDs and previous restrictions on LAMA use in New Zealand.
View article: Physician beliefs and management practices of coexistent Asthma-Allergic Rhinitis: Indian results from multi-country ASPAIR study
Physician beliefs and management practices of coexistent Asthma-Allergic Rhinitis: Indian results from multi-country ASPAIR study Open
Frequent coexistence and strong etiological linkage between asthma and allergic rhinitis (AR) result in higher burden with comorbid condition than individual disease. To understand attitude, perceptions, and current management practices am…
View article: Epidemiological, clinical and economic burden of severe eosinophilic asthma: Results from a large tertiary care hospital
Epidemiological, clinical and economic burden of severe eosinophilic asthma: Results from a large tertiary care hospital Open
Background: Burden of severe eosinophilic asthma (SEA) data in Asia are limited.Objective: This retrospective, observational study characterized SEA epidemiology, healthcare resource use (HCRU) and costs for adult patients in Taiwan.Method…
View article: Polycyclic aromatic hydrocarbon–DNA adducts and survival among women with breast cancer
Polycyclic aromatic hydrocarbon–DNA adducts and survival among women with breast cancer Open
Polycyclic aromatic hydrocarbons (PAH) are mammary carcinogens in animal studies, and a few epidemiologic studies have suggested a link between elevated levels of PAH-DNA adducts and breast cancer incidence. An association between PAH-DNA …
View article: Polycyclic Aromatic Hydrocarbon–DNA Adducts and Breast Cancer: A Pooled Analysis
Polycyclic Aromatic Hydrocarbon–DNA Adducts and Breast Cancer: A Pooled Analysis Open
Polycyclic aromatic hydrocarbon (PAH)-DNA adducts have been associated with breast cancer in several small studies. The authors’ pooled analysis included 873 cases and 941 controls from a population-based case-control study. Competitive en…
View article: Characterization and burden of severe eosinophilic asthma in New Zealand: Results from the HealthStat Database
Characterization and burden of severe eosinophilic asthma in New Zealand: Results from the HealthStat Database Open
Background: This retrospective cohort study aimed to characterize epidemiology, medication use and healthcare resource utilization (HCRU) of patients diagnosed with severe eosinophilic asthma (SEA) compared to other patients with asthma in…
View article: Menopausal hormone therapy use and long‐term all‐cause and cause‐specific mortality in the Long Island Breast Cancer Study Project
Menopausal hormone therapy use and long‐term all‐cause and cause‐specific mortality in the Long Island Breast Cancer Study Project Open
Previous studies have observed a reduced mortality risk associated with menopausal hormone therapy (MHT) use among breast cancer survivors. We sought to clarify whether such association could be explained by tumor heterogeneity, specific c…
View article: Polymorphisms in DNA repair genes, traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence: Polymorphisms in DNA
Polymorphisms in DNA repair genes, traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence: Polymorphisms in DNA Open
Vehicular traffic polycyclic aromatic hydrocarbons (PAHs) have been associated with breast cancer incidence in epidemiologic studies, including our own. Because PAHs damage DNA by forming adducts and oxidative lesions, genetic polymorphism…
View article: Vehicular Traffic–Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP)
Vehicular Traffic–Related Polycyclic Aromatic Hydrocarbon Exposure and Breast Cancer Incidence: The Long Island Breast Cancer Study Project (LIBCSP) Open
BackgroundPolycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in laboratory animals. However, the association between PAHs and breast cancer in women…
View article: Polycystic ovarian syndrome (PCOS), related symptoms/sequelae, and breast cancer risk in a population-based case–control study
Polycystic ovarian syndrome (PCOS), related symptoms/sequelae, and breast cancer risk in a population-based case–control study Open
Despite the overlap between the clinical symptoms/sequelae of polycystic ovarian syndrome (PCOS) and many known reproductive risk factors for breast cancer, the relationship between PCOS and breast cancer remains unclear, possibly because …