Sumon Pratihar
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View article: Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates
Sequence‐Specific Installation of Aryl Groups in RNA via DNA‐Catalyst Conjugates Open
Installing functional groups at specific sites in existing RNA molecules remains a challenge for modification, labeling, and therapeutic strategies. Here, we describe the use of DNA oligonucleotides carrying a catalytic amine group to effe…
View article: RNA 2’-OH modification with stable reagents enabled by nucleophilic catalysis
RNA 2’-OH modification with stable reagents enabled by nucleophilic catalysis Open
RNA modification at 2’-OH has typically required highly reactive acylating species that exhibit short half-lives in water, challenging purification, and limited shelf lives. Here, we investigate the use of more stable species as electrophi…
View article: Sequence-Specific Installation of Aryl Groups in RNA via DNA-Catalyst Conjugates
Sequence-Specific Installation of Aryl Groups in RNA via DNA-Catalyst Conjugates Open
Installing functional groups at specific sites in existing RNA molecules remains a challenge for modification, labeling, and therapeutic strategies. Here we describe the use of DNA oligonucleotides carrying a catalytic amine group to effec…
View article: RNA 2′-OH modification with stable reagents enabled by nucleophilic catalysis
RNA 2′-OH modification with stable reagents enabled by nucleophilic catalysis Open
RNA modification at 2′-OH commonly requires highly reactive reagents with short half-lives in water, challenging purification and limiting shelf life. Here, we describe moisture-stable reagents that react efficiently under nucleophilic cat…
View article: Small molecules and conjugates as theranostic agents
Small molecules and conjugates as theranostic agents Open
Small molecules with therapeutic and imaging capabilities can provide the desired theranostic effect for personalized medicine, either independently or when conjugated with a disease-specific targeting component.
View article: Nucleic Acid Architectonics for pH-Responsive DNA Systems and Devices
Nucleic Acid Architectonics for pH-Responsive DNA Systems and Devices Open
Nucleic acid-based architectures have opened up numerous opportunities for basic and applied research in the field of DNA nanotechnology. The scheme of molecular architectonics of nucleic acids exploits conventional and unconventional base…