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View article: Effect of <i>Aspergillus niger</i> Spores as Aeroallergen in Intra-Nasally Sensitized Mice Model
Effect of <i>Aspergillus niger</i> Spores as Aeroallergen in Intra-Nasally Sensitized Mice Model Open
Fungi are the eukaryotic spore-producing organisms found in various environments. Many fungal species and their spores can cause infections in humans. Exposure to the fungal spores may lead to allergic rhinitis and asthma in hypersensitive…
View article: Comparison Between C-MAC Blade D Video Laryngoscope and Macintosh Laryngoscope for Insertion of Double Lumen Tube in Patients Undergoing Elective Thoracic Surgeries
Comparison Between C-MAC Blade D Video Laryngoscope and Macintosh Laryngoscope for Insertion of Double Lumen Tube in Patients Undergoing Elective Thoracic Surgeries Open
The insertion of a double lumen tube (DLT) for lung isolation during thoracic surgeries is technically challenging and may be associated with airway trauma and significant hemodynamic fluctuations. Video laryngoscopy, particularly with dev…
View article: TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma
TFE3 fusion oncoprotein condensates drive transcriptional reprogramming and cancer progression in translocation renal cell carcinoma Open
Translocation renal cell carcinoma (tRCC) presents a significant clinical challenge due to its aggressiveness and limited treatment options. It is primarily driven by fusion oncoproteins (FOs), yet their role in oncogenesis is not fully un…
View article: Platinum chemotherapeutic-induced oxidative stress affects the transcriptional response of DNA repair genes in murine mesenchymal stem cells
Platinum chemotherapeutic-induced oxidative stress affects the transcriptional response of DNA repair genes in murine mesenchymal stem cells Open
This suggests that adult stem cells in tissues and organs are highly vulnerable to platinum drugs during cancer treatment. Additional studies on localized treatments may help to prevent adverse effects on normal cells.
View article: Comparative Study Of New Drug Application Procedure In Us, Eu And India
Comparative Study Of New Drug Application Procedure In Us, Eu And India Open
Developing a new drug requires great amount of research work in chemistry, manufacturing, controls, preclinical science and clinical trials. Drug reviewers in regulatory agencies around the world bear the responsibility of evaluating wheth…
View article: Cytotoxicity assays for cancer drug screening: methodological insights and considerations for reliable assessment in drug discovery
Cytotoxicity assays for cancer drug screening: methodological insights and considerations for reliable assessment in drug discovery Open
The importance of cytotoxicity assays in in vitro drug discovery investigations has led to their rising profile. Drugs and other substances can disrupt cell membranes, limit protein synthesis, and bind irreversibly to receptors, all of whi…
View article: Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells
Zinc enhances the cell adhesion, migration, and self-renewal potential of human umbilical cord derived mesenchymal stem cells Open
Acute pancreatitis (AP) often leads to a high incidence of cardiac injury, posing significant challenges in the treatment of severe AP and contributing to increased mortality rates. Mesenchymal stem cells (MSCs) release bioactive molecules…
View article: Extracellular Matrix Based 3D Scaffold for Directing the Fate of Adult Stem Cells into Osteogenic Lineage
Extracellular Matrix Based 3D Scaffold for Directing the Fate of Adult Stem Cells into Osteogenic Lineage Open
Background Bone defect causes softening of bone, reduction of bone density and mass, and degenerating bone microstructure which directly leads to bone fractures. Tissue-derived engineered cell-seeded hydrogel scaffolds are considered a pro…
View article: The pattern of RNA integrity and the expression of housekeeping genes are influenced by sodium hypochlorite and ascorbic acid.
The pattern of RNA integrity and the expression of housekeeping genes are influenced by sodium hypochlorite and ascorbic acid. Open
SHC (0.25%) is favorable in removing RNases and maintaining the integrity of RNA. cDNA synthesis did not affect by SHC treatment, and it follows the same as untreated samples after DNase 1 treatment. LAA drew a positive impact to improve t…
View article: Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells
Overexpression of GATA binding protein 4 and myocyte enhancer factor 2C induces differentiation of mesenchymal stem cells into cardiac-like cells Open
BACKGROUND: Heart diseases are the primary cause of death all over the world. Following myocardial infarction, billions of cells die, resulting in a huge loss of cardiac function. Stem cell-based therapies have appeared as a new area to su…
View article: Rapid Screening: Post Computerized Tomography Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Features in Asymptomatic Patients
Rapid Screening: Post Computerized Tomography Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Features in Asymptomatic Patients Open
Background: It is to document the frequency of incidental Corona Virus Disease-2019 (COVID-19) specific findings in patients imaged after the initial ten days of lockdown relief and the sensitivity of computed tomography (CT) in picking un…
View article: Developmental and Pluripotent Genes in Rat Adult and Neonatal Kidney
Developmental and Pluripotent Genes in Rat Adult and Neonatal Kidney Open
Frugivorous birds play important roles in seed dispersal.In this study, we assessed the contributions of bird functional traits (behavioral traits: foraging quantity, number of birds per visit, and foraging duration; morphological traits: …
View article: Opuntiol Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells by Upregulating Active Caspase 3 Expression
Opuntiol Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells by Upregulating Active Caspase 3 Expression Open
In conclusion our findings suggests, Opuntiol repress cell viability and possess strong apoptotic activity against GBM cell line U-87. However, further mechanistic studies will be required to confirm whether it can be develop as a potentia…
View article: Early operative outcome of pericardiectomy for symptomatic chronic tuberculous constrictive pericarditis
Early operative outcome of pericardiectomy for symptomatic chronic tuberculous constrictive pericarditis Open
Background: Pericardiectomy procedure is commonly indicated for constrictive pericarditis (CP). One of the most important clue to diagnosis of CP is the signs and symptoms of right-sided heart failure that are not completely explained by p…
View article: Modulation of Renal Parenchyma in Response to Allogeneic Adipose-Derived Mesenchymal Stem Cells Transplantation in Acute Kidney Injury
Modulation of Renal Parenchyma in Response to Allogeneic Adipose-Derived Mesenchymal Stem Cells Transplantation in Acute Kidney Injury Open
Ad-MSCs exerts pro-proliferative, anti-inflammatory, and anti-fibrotic effects. Ad-MSCs transplantation without any chemical or genetic manipulation can provide the evidence of therapeutic strategy for the origin of regeneration and overal…
View article: Engineering renal epithelial cells: programming and directed differentiation towards glomerular podocyte's progenitor and mature podocyte.
Engineering renal epithelial cells: programming and directed differentiation towards glomerular podocyte's progenitor and mature podocyte. Open
Current knowledge of normal developmental physiology and identification of specific cell types of the kidney at molecular levels enables us to generate various cells of the kidney. The generation of renal specialized cells in vitro with it…
View article: Estimation of total antioxidant capacity in type 2 diabetic and normal healthy subjects
Estimation of total antioxidant capacity in type 2 diabetic and normal healthy subjects Open
Background: Diabetes mellitus (DM) is a highly prevalent non-communicable disease in the world. Current investigations evolved that oxidative stress is also a major risk factor to cause type 2 diabetes mellitus due to impairment of antioxi…
View article: The Management of Glycemic Control in Associated Disorders
The Management of Glycemic Control in Associated Disorders Open
Glycemic control is a very useful parameter for the prevention of the chronic metabolic diseases complications such as diabetes, metabolic syndrome, cardiovascular and kidney disease. Glycemic control management among chronic metabolic dis…
View article: Effect of 2,4-Dinitrophenol preconditioning on the expression levels of mesenchymal markers in neonatal cardiac progenitors
Effect of 2,4-Dinitrophenol preconditioning on the expression levels of mesenchymal markers in neonatal cardiac progenitors Open
View article: Prevalence of Metabolic Syndrome among Obese Diabetic Subjects
Prevalence of Metabolic Syndrome among Obese Diabetic Subjects Open
Background: Metabolic syndrome (MS) is a cluster of metabolic risk factors including obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. MS in obese and type 2 diabetic (T2DM) subjects increase…