Jun Sun
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View article: Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation
Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation Open
Overall, deletion of intestinal epithelial SNX27 weakens barrier functions and promotes inflammation. Our results indicate a novel role of SNX27 in regulating intestinal physiology and protecting against intestinal disorders. Thus, underst…
View article: Stability of volume and area preserving mean curvature flow in asymptotic Schwarzschild space
Stability of volume and area preserving mean curvature flow in asymptotic Schwarzschild space Open
In this paper, we investigate the stability of the volume preserving mean curvature flow (VPMCF) and area preserving mean curvature flow (APMCF) in the Schwarzschild space. We show that if the initial hypersurface is sufficiently close to …
View article: Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension
Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension Open
Schistosomiasis-associated Pulmonary Hypertension (Sch-PH) is the most common form of group I PH worldwide. Recently, data revealed that the preclinical animal model of Sch-PH exhibited gut and lung microbiome dysbiosis linked to significa…
View article: Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis Through the Gut‐Neuron Axis
Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis Through the Gut‐Neuron Axis Open
Emerging evidence has shown that gut‐brain barrier dysfunction occurs at the early stages of ALS. Previous studies demonstrated that sodium butyrate significantly prolonged the life span of ALS mice. Riluzole is the first FDA‐approved drug…
View article: Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation
Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation Open
Backgrounds and aims: SNX27, member of the sorting nexin (SNX) family, carries a unique PDZ domain and mediates recycling of endocytosed transmembrane proteins. SNX27 is critical for neurodevelopmental processes, however its role in intest…
View article: A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions
A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions Open
Post-Acute Sequelae of SARS-CoV-2 infection (PASC or “Long COVID”), includes numerous chronic conditions associated with widespread morbidity and rising healthcare costs. PASC has highly variable clinical presentations, and likely includes…
View article: Albumin for patients with acute large-vessel occlusive stroke undergoing endovascular therapy (ARISE): the protocol of a randomized double-blind trial.
Albumin for patients with acute large-vessel occlusive stroke undergoing endovascular therapy (ARISE): the protocol of a randomized double-blind trial. Open
www.clinicaltrials.gov, NCT06538844.
View article: Clinical Validation of a 12-Target Multiplex Fluorescent Pcr (Automolec 3000) for Rapid Detection of Lower Respiratory Tract Pathogens
Clinical Validation of a 12-Target Multiplex Fluorescent Pcr (Automolec 3000) for Rapid Detection of Lower Respiratory Tract Pathogens Open
View article: Using Serum Metabolomic Signatures to Investigate Effects of Acupuncture on Pain-Fatigue-Sleep Disturbance in Breast Cancer Survivors
Using Serum Metabolomic Signatures to Investigate Effects of Acupuncture on Pain-Fatigue-Sleep Disturbance in Breast Cancer Survivors Open
Background/Objectives: Acupuncture is an efficacious integrative therapy for treating pain, fatigue, and sleep disturbance (the psychoneurological symptom cluster) in breast cancer survivors. However, the mechanisms underlying its effects …
View article: IRIS, a randomised, double-blind, placebo-controlled trial of interleukin-6 receptor inhibition undergoing endovascular treatment in acute anterior circulation ischaemic stroke: study rationale and design
IRIS, a randomised, double-blind, placebo-controlled trial of interleukin-6 receptor inhibition undergoing endovascular treatment in acute anterior circulation ischaemic stroke: study rationale and design Open
Rationale Neuroprotective strategies based on reperfusion therapy hold substantial promise for acute ischaemic stroke (AIS). Preclinical research indicates that tocilizumab, an interleukin-6 receptor antagonist, can attenuate ischaemia-rep…
View article: Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis in SOD1G93A mice
Synergistic Effects of Riluzole and Sodium Butyrate on Barrier Function and Disease Progression of Amyotrophic Lateral Sclerosis in SOD1G93A mice Open
Emerging evidence has shown that gut-brain barrier dysfunction occurs at the early stages of ALS. Previous studies demonstrated that Sodium butyrate significantly decreased aggregation of the human-SOD1G93A protein, improved int…
View article: Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction
Early pathological mechanisms in a mouse model of heart failure with preserved ejection fraction Open
Our study demonstrates that feeding mice a Western diet rich in fat and salt and low in fiber alongside excess mineralocorticoids replicates aspects of human HFpEF. Cardiac alterations including diastolic dysfunction and decreased stroke v…
View article: Stability of the area preserving mean curvature flow in asymptotic Schwarzschild space
Stability of the area preserving mean curvature flow in asymptotic Schwarzschild space Open
We first demonstrate that the area preserving mean curvature flow of hypersurfaces in space forms exists for all time and converges exponentially fast to a round sphere if the integral of the traceless second fundamental form is sufficient…
View article: Comparative analysis of the femoral neck system (FNS) vs. cannulated cancellous screws (CCS) in the treatment of Middle-aged and elderly patients with femoral neck fractures: clinical outcomes and biomechanical insights
Comparative analysis of the femoral neck system (FNS) vs. cannulated cancellous screws (CCS) in the treatment of Middle-aged and elderly patients with femoral neck fractures: clinical outcomes and biomechanical insights Open
The treatment of femoral neck fractures with FNS is superior and contributes to improved hip joint function. Biomechanical research has confirmed its structural stability and advantages in resisting femoral head varus. However, challenges …
View article: Bringing Vitamin D and the Vitamin D Receptor into the Limelight
Bringing Vitamin D and the Vitamin D Receptor into the Limelight Open
Classically, vitamin D is known to regulate skeletal and mineral ion homeostasis [...]
View article: Microbiome and micronutrient in ALS: From novel mechanisms to new treatments
Microbiome and micronutrient in ALS: From novel mechanisms to new treatments Open
Amyotrophic lateral sclerosis is a neurodegenerative disorder. Despite extensive studies, it remains challenging to treat ALS. Recent ALS studies have shown dysbiosis (e.g., loss of microbial diversity and beneficial function in the gut mi…
View article: Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment
Poking at probiotic mechanisms and microbial implications in cancer prevention and treatment Open
View article: Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice
Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice Open
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. The ALS mice expressing human mutant of transactive response DNA binding protein of 43 kDa (hmTDP43) showed intestinal dysfunction before neuromuscular symptoms. We hypothesiz…
View article: IHIBITION OF TRNA QUEUOSINE MODIFICATION CAUSE MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS IN THE INTESTINAL EPITHELIAL CELLS
IHIBITION OF TRNA QUEUOSINE MODIFICATION CAUSE MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS IN THE INTESTINAL EPITHELIAL CELLS Open
BACKGROUND Transfer RNA (tRNA) modifications occur through the action of specific enzymes that recognize and modify the nucleotides within the tRNA molecule. Queuine tRNA-ribosyltransferase catalytic subunit 1 (QTRT1) and QTRT 2 co-localiz…
View article: Conditional Vitamin D Receptor Deletion Induces Fungal and Archaeal Dysbiosis and Altered Metabolites
Conditional Vitamin D Receptor Deletion Induces Fungal and Archaeal Dysbiosis and Altered Metabolites Open
A vitamin D receptor (VDR) deficiency leads to the dysbiosis of intestinal bacteria and is associated with various diseases, including cancer, infections, and inflammatory bowel disease. However, the impact of a VDR deficiency on fungi and…
View article: Axin1‘s mystique in manipulating microbiome amidst colitis
Axin1‘s mystique in manipulating microbiome amidst colitis Open
Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1's roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial …
View article: Navigating the complex landscape of non‐alcoholic fatty liver disease: From genomic associate to the AMPK/mTOR pathways
Navigating the complex landscape of non‐alcoholic fatty liver disease: From genomic associate to the AMPK/mTOR pathways Open
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases from steatosis (fat accumulation in hepatocytes) to non-alcoholic steatohepatitis (NASH), which may further progress to cirrhosis and hepatocellular carcinoma (HCC).…
View article: WS02.15 Effect of Gut Microbiome on Metastasis of Non-small Cell Lung Cancer
WS02.15 Effect of Gut Microbiome on Metastasis of Non-small Cell Lung Cancer Open
View article: Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting
Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans: report of an expert meeting Open
The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled "Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans." Our Veteran patient population exper…
View article: Salmonella infection acts as an environmental risk factor for human colon cancer
Salmonella infection acts as an environmental risk factor for human colon cancer Open
Emerging evidence has demonstrated that perturbations of host-microbial interactions by pathogens can lead to an altered microenvironment that promotes tumorigenesis. A recent study provides new evidence and mechanisms on how repetitive ex…
View article: [Clinical application of parathyroid autofluorescence imaging in endoscopic thyroid surgery].
[Clinical application of parathyroid autofluorescence imaging in endoscopic thyroid surgery]. Open
Objective:To investigate the application value of near-infrared autofluorescence imaging in identifying and protecting parathyroid glands in endoscopic thyroid surgery. Methods:From May 2022 to February 2023, 158 patients who…
View article: Metabolites and micronutrition in modulating amyotrophic lateral sclerosis
Metabolites and micronutrition in modulating amyotrophic lateral sclerosis Open
Department of Medicine, University of Illinois Chicago, Chicago, IL, USA (Claud K, Sun J) Jesse Brown VA Medical Center Chicago, Chicago, IL, USA (Sun J) *Correspondence to: Jun Sun, PhD, [email protected]. This is an open-access article d…
View article: Proceedings of the IEEE Publication Information
Proceedings of the IEEE Publication Information Open
View article: Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota
Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota Open
View article: Pretreating and normalizing metabolomics data for statistical analysis
Pretreating and normalizing metabolomics data for statistical analysis Open
Metabolomics as a research field and a set of techniques is to study the entire small molecules in biological samples. Metabolomics is emerging as a powerful tool generally for precision medicine. Particularly, integration of microbiome an…