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Adenylosuccinate Synthase 1 Deficiency Improves Energy Metabolism by Promoting Adipose Tissue Re‐esterification via Glycerol Kinase Upregulation Open

Jingjing Sun, Miriayi Alimujiang, Wenfei Li, Shuqin Chen, Yingying Su , et al. · 2025

Purine metabolism enzymes have a well‐established role in maintaining the nucleotide pool, thereby sustaining cellular energy homeostasis. Although reduced purine nucleotide concentrations have been reported can influence uncoupling protei…

Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging Open

Pengcheng Shen, Zheyu Yang, Jingjing Sun, Yun Wang, Cheng Qiu , et al. · 2025

NiCu alloy nanoparticles encapsulated in nitrogen-doped carbon nanotubes for highly efficient acidic hydrogen evolution reaction Open

Shuang Ma, Xiangxiang Wang, Xu Zhang, Jingjing Sun, Heng Zhang , et al. · 2025

Endostatin-based anti-angiogenic therapy and immune modulation: mechanisms and synergistic potential in cancer treatment Open

Jingjing Sun, Simeng Ren, QingYun Zhao, JiaXin He, Yaxuan Wang , et al. · 2025

Cancer remains a critical global health challenge, driven by tumor angiogenesis and immune evasion. Endostatin, a collagen XVIII-derived fragment, uniquely suppresses angiogenesis and reprograms the immunosuppressive tumor microenvironment…

Figure S8 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Figure S8

Figure S6 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

FADD and CCND1 co-inhibition restrained cell proliferation

Figure S5 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

FADD overexpression accelerated S-phase entry

Table S2 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Correlation between FADD and clinicopathologic characteristics in 238 HNSCC cases in JS cohort.

Table S3 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

shRNA sequences, CRISPR guide RNA squences and primer sequences for qPCR.

Supplementary figure legends from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Supplementary figure legends

Figure S4 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Figure S4

Table S5 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Proteomics Analysis of Protein Level Changes in control group cells.

Figure S1 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Clarifying the role of chr11q13.3 and the related genes in this amplicon in HNSCC

Table S1 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Correlation between Chr11q13.3 Amp and FADD staining and clinicopathologic characteristics in 64 HNSCC cases in 9h cohort.

Data from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Chromosomal 11q13.3 amplification is the most common gene copy-number variation event in head and neck squamous cell carcinoma (HNSCC) that corresponds with poor prognosis. Although cyclin D1, a G₁/S phase cell-cycle regulatory …

Table S6 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Proteomics Analysis of Protein Level Changes in FADD knock-out cells.

Figure S7 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Combined PHA-767491 and Abemaciclib markedly restricted cell growth in chr11q13.3-amplified cells

Figure S3 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

FADD exhibits a significant increase in expression during tumor progression.

Table S4 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

IP-mass analysis in Flag-FADD-overexpressed 293T cells.

Figure S2 from FADD Functions as an Oncogene in Chr11q13.3-Amplified Head and Neck Squamous Cell Carcinoma Open

Yang Zheng, Yinan Chen, Xiaoyan Meng, Li Zhang, Yanni Ma , et al. · 2025

Correlation between CNA and mRNA Expression Observed in TCGA Datasets

Investigative needle core biopsies support multimodal deep-data generation in glioblastoma Open

Kenny Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev , et al. · 2025

Glioblastoma (GBM) is an aggressive primary brain cancer with few effective therapies. Stereotactic needle biopsies are routinely used for diagnosis; however, the feasibility and utility of investigative biopsies to monitor treatment respo…

The precise molecular diagnosis of novel GLDC compound heterozygous variants highlights the benefits for a Chinese family with nonketotic hyperglycinemia Open

Yuan Fang, Xiaozhen Song, Rongrong Yin, Xiaoping Lan, Jingjing Sun , et al. · 2025

Glycine encephalopathy, also known as nonketotic hyperglycinemia (NHK), is a rare inherited disease caused by an inborn error of glycine metabolism, resulting in elevated glycine concentration in plasma and cerebrospinal fluid. Clinical ma…

Investigative needle core biopsies for multi-omics in Glioblastoma Open

Kenny K.H. Yu, Sreyashi Basu, Gerard Baquer, Ryuhjin Ahn, Jennifer Gantchev , et al. · 2023

Glioblastoma (GBM) is a primary brain cancer with an abysmal prognosis and few effective therapies. The ability to investigate the tumor microenvironment before and during treatment would greatly enhance both understanding of disease respo…

Advances and established therapies in linear scar prevention Open

Jingjing Sun, Yajing Qiu, Xiaoxi Lin · 2023

Linear scars are scars formed after surgery or other trauma-healing procedures that typically exhibit a linear morphology. Optimal linear scars are characterized by narrowness, flatness, and a color closely resembling the adjacent tissue. …

Neoadjuvant immunochemotherapy for locally advanced resectable oral squamous cell carcinoma: a prospective single-arm trial (Illuminate Trial) Open

Yingying Huang, Jingjing Sun, Jun Li, Dongwang Zhu, Minjun Dong , et al. · 2023

Background: Locally advanced oral squamous cell carcinoma (LAOSCC) is associated with a high rate of recurrence and poor survival. Given the recent successes of neoadjuvant immunochemotherapy (NAICT) in solid tumors, it is promising to use…

Can adjuvant radiotherapy be omitted for oral cavity cancer patients who received neoadjuvant therapy and surgery? A retrospective cohort study Open

Wu‐tong Ju, Yiyi Zhang, Ying Liu, Jingjing Sun, Jiang Li , et al. · 2023

Background: Surgery and postoperative adjuvant therapy comprise the standard treatment for locally advanced resectable oral squamous cell carcinoma (LAROSCC), while preoperative neoadjuvant therapy is being explored without sufficient conf…

Estimating Commonly Used Partition and Adsorption Coefficients of 943 Chemicals and Their Temperature Dependence Open

Pu-Fei Yang, Wan-Li Ma, Hang Xiao, Kaj Mantzius Hansen, Liang Wang , et al. · 2023

Four-copy number alteration (CNA)-related lncRNA prognostic signature for liver cancer Open

Zhenyun Cheng, Yan Guo, Jingjing Sun, Lei Zheng · 2022

PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes Open

Fan Hu, Chang Li, Yafen Ye, Xuhong Lu, Miriayi Alimujiang , et al. · 2022

PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown. Here, we report a central function of PARP12 in thermogeni…

CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue Open

Ningning Bai, Xuhong Lu, Jin Li, Miriayi Alimujiang, Jingyuan Ma , et al. · 2022

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